An anchor-tether 'hindered' HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model.

[1]  Elizabeth D. Kim,et al.  Perturbation of HCN1 response to small molecule modulation. , 2023, Biophysical Journal.

[2]  G. Khelashvili,et al.  Phospholipid Scrambling by G Protein-Coupled Receptors. , 2021, Annual review of biophysics.

[3]  Michael C. Lee,et al.  Role of hyperpolarization-activated cyclic nucleotide-gated ion channels in neuropathic pain: a proof-of-concept study of ivabradine in patients with chronic peripheral neuropathic pain , 2021, Pain reports.

[4]  G. Tamás,et al.  Systemic administration of ivabradine, a hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, blocks spontaneous absence seizures , 2021, Epilepsia.

[5]  P. A. Goldstein,et al.  Non-canonical molecular targets for novel analgesics: Intracellular calcium and HCN channels. , 2021, Current neuropharmacology.

[6]  C. Reid,et al.  Testing broad-spectrum and isoform-preferring HCN channel blockers for anticonvulsant properties in mice , 2020, Epilepsy Research.

[7]  S. Raja,et al.  John J. Bonica Award Lecture: Peripheral neuronal hyperexcitability: the "low-hanging" target for safe therapeutic strategies in neuropathic pain. , 2020, Pain.

[8]  Stephanie I. Shiers,et al.  Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization. , 2020, Pain.

[9]  E. Lindahl,et al.  Shared structural mechanisms of general anesthetics and benzodiazepines , 2020, Nature.

[10]  D. DiFrancesco.  A Brief History of Pacemaking , 2020, Frontiers in Physiology.

[11]  M. Shah,et al.  Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders. , 2020, Annual review of pharmacology and toxicology.

[12]  M. Biel,et al.  HCN3 ion channels: roles in sensory neuronal excitability and pain , 2019, The Journal of physiology.

[13]  Michael C. Lee,et al.  A randomised, double blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial. , 2019, Pain.

[14]  G. Rao,et al.  Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons. , 2019, Brain : a journal of neurology.

[15]  R. Eckenhoff,et al.  Alkylphenol inverse agonists of HCN1 gating: H‐bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency , 2019, Biochemical pharmacology.

[16]  Xin Zhao,et al.  Hyperpolarization-activated and cyclic nucleotide-gated channel proteins as emerging new targets in neuropathic pain , 2019, Reviews in the neurosciences.

[17]  G. Guyatt,et al.  Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis , 2018, JAMA.

[18]  Tara Gomes,et al.  The Burden of Opioid-Related Mortality in the United States , 2018, JAMA network open.

[19]  C. Ghelardini,et al.  Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy , 2018, Neuropharmacology.

[20]  F. Crea,et al.  Expert consensus document: A 'diamond' approach to personalized treatment of angina , 2018, Nature Reviews Cardiology.

[21]  M. Kano,et al.  A mutant HCN4 channel in a family with bradycardia, left bundle branch block, and left ventricular noncompaction , 2018, Heart and Vessels.

[22]  A. Masi,et al.  The Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels , 2017, Pharmacological Reviews.

[23]  P. McNaughton,et al.  Hyperpolarization-activated cyclic nucleotide–gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy , 2017, Science Translational Medicine.

[24]  Irina Vetter,et al.  Methods Used to Evaluate Pain Behaviors in Rodents , 2017, Front. Mol. Neurosci..

[25]  M. Szczyrek,et al.  Ivabradine attenuates the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice , 2017, Epilepsy Research.

[26]  P. Wiffen,et al.  Morphine for chronic neuropathic pain in adults. , 2017, The Cochrane database of systematic reviews.

[27]  R. Schumann,et al.  Methadone for neuropathic pain in adults. , 2017, The Cochrane database of systematic reviews.

[28]  R. MacKinnon,et al.  Structures of the Human HCN1 Hyperpolarization-Activated Channel , 2017, Cell.

[29]  A. Zwolak,et al.  Influence of Ivabradine on the Anticonvulsant Action of Four Classical Antiepileptic Drugs Against Maximal Electroshock-Induced Seizures in Mice , 2017, Neurochemical Research.

[30]  P. Wiffen,et al.  Fentanyl for neuropathic pain in adults. , 2016, The Cochrane database of systematic reviews.

[31]  R. Moore,et al.  Oxycodone for neuropathic pain in adults. , 2016, The Cochrane database of systematic reviews.

[32]  G. Tibbs,et al.  Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain? , 2016, Trends in pharmacological sciences.

[33]  William T. Ralvenius,et al.  Phosphorylation state – dependent modulation of spinal glycine receptors alleviates inflammatory pain , 2022 .

[34]  Anabella Villalobos,et al.  Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery. , 2016, ACS chemical neuroscience.

[35]  Hong Zhang,et al.  Age-associated expression of HCN channel isoforms in rat sinoatrial node , 2016, Experimental biology and medicine.

[36]  Hengling Chen,et al.  Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes , 2015, Neuroreport.

[37]  M. Rosen,et al.  Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart , 2015, Circulation. Arrhythmia and electrophysiology.

[38]  Berk Hess,et al.  GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers , 2015 .

[39]  C. Tsantoulas.  Emerging potassium channel targets for the treatment of pain , 2015, Current opinion in supportive and palliative care.

[40]  Blair H. Smith,et al.  Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis , 2015, The Lancet Neurology.

[41]  R. Wilders,et al.  Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current , 2015, International journal of molecular sciences.

[42]  D. Fiellin,et al.  Prescription opioid misuse in the United States and the United Kingdom: cautionary lessons. , 2014, The International journal on drug policy.

[43]  Alex Gutteridge,et al.  Characterizing Human Stem Cell-derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research. , 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

[44]  Tony O’Brien,et al.  The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care , 2013, BMC Public Health.

[45]  A. Prystupa,et al.  Ivabradine (a hyperpolarization activated cyclic nucleotide-gated channel blocker) elevates the threshold for maximal electroshock-induced tonic seizures in mice , 2013, Pharmacological reports : PR.

[46]  A. Proekt,et al.  HCN1 Channels as Targets for Anesthetic and Nonanesthetic Propofol Analogs in the Amelioration of Mechanical and Thermal Hyperalgesia in a Mouse Model of Neuropathic Pain , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[47]  C. Shapiro,et al.  Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. , 2013, JAMA.

[48]  Patrick Richard,et al.  The economic costs of pain in the United States. , 2012, The journal of pain : official journal of the American Pain Society.

[49]  L. Djouhri,et al.  Expression and properties of hyperpolarization-activated current in rat dorsal root ganglion neurons with known sensory function , 2012, The Journal of physiology.

[50]  R. Nirogi,et al.  Comparison of manual and automated filaments for evaluation of neuropathic pain behavior in rats. , 2012, Journal of pharmacological and toxicological methods.

[51]  A. Mugelli,et al.  Novel blockers of hyperpolarization‐activated current with isoform selectivity in recombinant cells and native tissue , 2012, British journal of pharmacology.

[52]  Andreas A Linninger,et al.  Interspecies scaling in pharmacokinetics: a novel whole-body physiologically based modeling framework to discover drug biodistribution mechanisms in vivo. , 2012, Journal of pharmaceutical sciences.

[53]  Ralf Baron,et al.  Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms , 2012, Neuron.

[54]  A. Ludwig,et al.  Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart. , 2011, Journal of molecular and cellular cardiology.

[55]  Cheryl A. Grice,et al.  Discovery of a novel series of selective HCN1 blockers. , 2011, Bioorganic & medicinal chemistry letters.

[56]  P. McNaughton,et al.  HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain , 2011, Science.

[57]  M R Boyett,et al.  Molecular architecture of the human specialised atrioventricular conduction axis. , 2011, Journal of molecular and cellular cardiology.

[58]  Michael Böhm,et al.  Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study , 2010, The Lancet.

[59]  A. Mugelli,et al.  Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. , 2010, Journal of medicinal chemistry.

[60]  Alexander D. MacKerell,et al.  Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types. , 2010, The journal of physical chemistry. B.

[61]  P. Verhoest,et al.  Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties. , 2010, ACS Chemical Neuroscience.

[62]  T. Jensen,et al.  Pharmacology and treatment of neuropathic pains , 2009, Current opinion in neurology.

[63]  Erich Wettwer,et al.  Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts , 2009, Pflügers Archiv - European Journal of Physiology.

[64]  M. Bennett,et al.  Diagnosis and management of neuropathic pain , 2009, BMJ : British Medical Journal.

[65]  Alexander D. MacKerell,et al.  CHARMM general force field: A force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields , 2009, J. Comput. Chem..

[66]  William A Banks,et al.  Characteristics of compounds that cross the blood-brain barrier , 2009, BMC neurology.

[67]  Robert H. Anderson,et al.  Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker , 2009, Circulation.

[68]  A. Mason,et al.  Role of the hyperpolarization‐activated current Ih in somatosensory neurons , 2008, The Journal of physiology.

[69]  R. Ferrari,et al.  Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial , 2008, The Lancet.

[70]  J. Borer,et al.  Characterization of the Heart Rate-Lowering Action of Ivabradine, a Selective If Current Inhibitor , 2008, American journal of therapeutics.

[71]  S. Nattel,et al.  Molecular basis of funny current (If) in normal and failing human heart. , 2008, Journal of molecular and cellular cardiology.

[72]  Taehoon Kim,et al.  CHARMM‐GUI: A web‐based graphical user interface for CHARMM , 2008, J. Comput. Chem..

[73]  Jisheng Han,et al.  Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat , 2008, PAIN®.

[74]  A. Dray,et al.  Neuropathic pain: emerging treatments. , 2008, British journal of anaesthesia.

[75]  R. Ring,et al.  Hyperpolarization-activated cyclic nucleotide-gated channel mRNA and protein expression in large versus small diameter dorsal root ganglion neurons: Correlation with hyperpolarization-activated current gating , 2008, Neuroscience.

[76]  Y. Wan,et al.  Characteristics of HCN Channels and Their Participation in Neuropathic Pain , 2008, Neurochemical Research.

[77]  T. Baram,et al.  Activity‐dependent heteromerization of the hyperpolarization‐activated, cyclic‐nucleotide gated (HCN) channels: role of N‐linked glycosylation , 2008, Journal of neurochemistry.

[78]  D. Chialvo,et al.  Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics , 2008, The Journal of Neuroscience.

[79]  G. Y. Wong,et al.  Efficacy of gabapentin in the management of chemotherapy‐induced peripheral neuropathy , 2007, Cancer.

[80]  M. D'Andrea,et al.  Attenuated Cold Sensitivity in TRPM8 Null Mice , 2007, Neuron.

[81]  A. Dubin,et al.  Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat , 2007, Neuroscience.

[82]  S. Siegelbaum,et al.  Voltage Sensor Movement and cAMP Binding Allosterically Regulate an Inherently Voltage-independent Closed−Open Transition in HCN Channels , 2007, The Journal of general physiology.

[83]  D. DiFrancesco.  Funny channels in the control of cardiac rhythm and mode of action of selective blockers. , 2006, Pharmacological research.

[84]  Loren J. Martin,et al.  α5GABAA Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate , 2006, The Journal of Neuroscience.

[85]  D. Bayliss,et al.  Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons. , 2005, Journal of neurophysiology.

[86]  N. Harrison,et al.  Impairment of Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Intravenous General Anesthetic Propofol , 2005, Journal of Pharmacology and Experimental Therapeutics.

[87]  T. Baram,et al.  Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures , 2005, Neurobiology of Disease.

[88]  R. Shigemoto,et al.  Immunohistochemical localization of Ih channel subunits, HCN1–4, in the rat brain , 2004, The Journal of comparative neurology.

[89]  Z. Wang,et al.  Animal and cellular models of chronic pain. , 2003, Advanced drug delivery reviews.

[90]  T. Yamakura,et al.  Differential Effects of General Anesthetics on G Protein–coupled Inwardly Rectifying and Other Potassium Channels , 2001, Anesthesiology.

[91]  S. Siegelbaum,et al.  Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide , 2001, The Journal of general physiology.

[92]  M. Biel,et al.  Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. , 2001, European journal of biochemistry.

[93]  C. Woolf,et al.  Spared nerve injury: an animal model of persistent peripheral neuropathic pain , 2000, Pain.

[94]  T. Bortfeld,et al.  Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions. , 2000, Physics in medicine and biology.

[95]  D. Mckinnon,et al.  Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. , 1999, Circulation research.

[96]  Berk Hess,et al.  LINCS: A linear constraint solver for molecular simulations , 1997, J. Comput. Chem..

[97]  T. Darden,et al.  A smooth particle mesh Ewald method , 1995 .

[98]  S. Gardiner,et al.  Acute and chronic cardiac and regional haemodynamic effects of the novel bradycardic agent, S16257, in conscious rats , 1995, British journal of pharmacology.

[99]  R. Dubner,et al.  A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia , 1987, Pain.

[100]  Hoover,et al.  Canonical dynamics: Equilibrium phase-space distributions. , 1985, Physical review. A, General physics.

[101]  S. Nosé.  A molecular dynamics method for simulations in the canonical ensemble , 1984 .

[102]  W. L. Jorgensen,et al.  Comparison of simple potential functions for simulating liquid water , 1983 .

[103]  M. Parrinello,et al.  Polymorphic transitions in single crystals: A new molecular dynamics method , 1981 .

[104]  S. Bergese,et al.  A comprehensive literature review , 2019 .

[105]  D. Macêdo,et al.  Ivabradine possesses anticonvulsant and neuroprotective action in mice. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[106]  R. Freeman,et al.  Neuropathic pain , 1999, The Lancet.

[107]  Y. Uezono,et al.  Analysis of the effects of anesthetics and ethanol on mu-opioid receptor. , 2010, Journal of pharmacological sciences.

[108]  Annalisa Bucchi,et al.  The cardiac pacemaker current. , 2010, Journal of molecular and cellular cardiology.

[109]  A. Prus.  Conditioned Place Preference , 2009 .

[110]  Soraya Dhillon,et al.  Basic pharmacokinetics , 2006 .