A “radical” view of cerebral ischemic injury

[1]  J. Phillis,et al.  Oxypurinol attenuates hydroxyl radical production during ischemia/reperfusion injury of the rat cerebral cortex: an ESR study , 1993, Brain Research.

[2]  Joseph Loscalzo,et al.  A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds , 1993, Nature.

[3]  A. Buisson,et al.  Mechanisms Involved in the Neuroprotective Activity of a Nitric Oxide Synthase Inhibitor During Focal Cerebral Ischemia , 1993, Journal of neurochemistry.

[4]  C. Piantadosi,et al.  Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia , 1993, Neuroscience Letters.

[5]  S. Bondy,et al.  Oxidative stress induced by glutamate receptor agonists , 1993, Brain Research.

[6]  Guangheng Liu,et al.  Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvessels. , 1993, Free radical biology & medicine.

[7]  S. Bradamante,et al.  The hydrophilic spin trap, 5,5-dimethyl-1-pyrroline-1-oxide, does not protect the rat heart from reperfusion injury , 1993 .

[8]  A. Lawrence,et al.  Nitric oxide increases interstitial excitatory amino acid release in the rat dorsomedial medulla oblongata , 1993, Neuroscience Letters.

[9]  F. Barone,et al.  Distribution of spin-trapping compounds in rat blood and brain: in vivo microdialysis determination. , 1993, Free radical biology & medicine.

[10]  J. Phillis,et al.  alpha-Phenyl-tert-butyl-nitrone (PBN) attenuates hydroxyl radical production during ischemia-reperfusion injury of rat brain: an EPR study. , 1993, Free radical research communications.

[11]  Barry Halliwell,et al.  Reactive Oxygen Species and the Central Nervous System , 1992, Journal of neurochemistry.

[12]  M. Moskowitz,et al.  Oxygen radicals in cerebral ischemia. , 1992, The American journal of physiology.

[13]  A. Buisson,et al.  The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia , 1992, British journal of pharmacology.

[14]  J. Phillis,et al.  Excitatory Transmitter Amino Acid Release from the Ischemic Rat Cerebral Cortex: Effects of Adenosine Receptor Agonists and Antagonists , 1992, Journal of neurochemistry.

[15]  L. Agnati,et al.  Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis , 1992, Neuroscience Letters.

[16]  E. Monti,et al.  Protective activity of the spin trap tert-bytyl-α-phenyl nitrone (PBN) in reperfused rat heart , 1992 .

[17]  T. Yue,et al.  Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons , 1992, Brain Research.

[18]  J. Phillis,et al.  Deoxycoformycin and oxypurinol: protection against focal ischemic brain injury in the rat , 1992, Brain Research.

[19]  D. Boisvert.  In Vivo Generation of Hydroxyl Radicals During Glutamate Exposure , 1992 .

[20]  E. Monti,et al.  Subcellular distribution of two spin trapping agents in rat heart: possible explanation for their different protective effects against doxorubicin-induced cardiotoxicity. , 1992, Free radical research communications.

[21]  B. Scatton,et al.  Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. , 1991, European journal of pharmacology.

[22]  J. Repine,et al.  Generation of superoxide anion by brain endothelial cell xanthine oxidase , 1991, Journal of cellular physiology.

[23]  S. Snyder,et al.  Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[24]  A. Betz,et al.  Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats. , 1991, Stroke.

[25]  R. Floyd,et al.  Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A. Richardson,et al.  Expression of supreoxide dismutase and catalase in rat brain as a function of age , 1991, Mechanisms of Ageing and Development.

[27]  J. Phillis,et al.  The free radical trapping agent N-tert.-butyl-alpha-phenylnitrone (PBN) attenuates cerebral ischaemic injury in gerbils. , 1991, Free radical research communications.

[28]  J. Phillis,et al.  Oxypurinol reduces ischemic brain injury in the gerbil and rat. , 1991, Advances in experimental medicine and biology.

[29]  E. Monti,et al.  Protective effects of spin-trapping agents on adriamycin-induced cardiotoxicity in isolated rat atria. , 1991, Free radical research communications.

[30]  R. Pérez-Campo,et al.  Anti-oxidant defences and peroxidation in liver and brain of aged rats. , 1990, The Biochemical journal.

[31]  J. Phillis,et al.  Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-α-phenylnitrone (PBN) , 1990, Neuroscience Letters.

[32]  D. Long,et al.  The molecular basis of brain injury and brain edema: the role of oxygen free radicals. , 1990 .

[33]  J. Schmidley.  Free radicals in central nervous system ischemia. , 1990, Stroke.

[34]  F. Moroni,et al.  Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[35]  R. Floyd,et al.  Role of oxygen free radicals in carcinogenesis and brain ischemia , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  D. Lange,et al.  A continuous in vivo model of ischemia/reperfusion induced free radical formation in the cerebral spinal fluid (CSF) of pigs using spin-trapping agents and electron paramagnetic resonance (EPR) techniques , 1990 .

[37]  I. Blasig,et al.  Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts. , 1990, Free radical biology & medicine.

[38]  U. Ungerstedt,et al.  Dynamics of Extracellular Metabolites in the Striatum after Middle Cerebral Artery Occlusion in the Rat Monitored by Intracerebral Microdialysis , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[39]  M. Ishikawa,et al.  Lipid peroxidation in focal cerebral ischemia. , 1989, Journal of neurosurgery.

[40]  T. Devasagayam.  Decreased peroxidative potential in rat brain microsomal fractions during ageing , 1989, Neuroscience Letters.

[41]  B. Grøgaard,et al.  Delayed Hypoperfusion after Incomplete Forebrain Ischemia in the Rat. The Role of Polymorphonuclear Leukocytes , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[42]  R. Burney,et al.  Neutrophil depletion fails to improve neurologic outcome after cardiac arrest in dogs. , 1989, Annals of emergency medicine.

[43]  M. Wajner,et al.  Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues. , 1989, Biochimica et biophysica acta.

[44]  S. Rehncrona,et al.  Enhancement of Iron-Catalyzed Free Radical Formation by Acidosis in Brain Homogenates: Difference in Effect by Lactic Acid and CO2 , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[45]  H. Kontos,et al.  Oxygen radicals in CNS damage. , 1989, Chemico-biological interactions.

[46]  R. Busto,et al.  Effect of Ischemia on the In Vivo Release of Striatal Dopamine, Glutamate, and γ‐Aminobutyric Acid Studied by Intracerebral Microdialysis , 1988, Journal of neurochemistry.

[47]  L. Ernster.  Biochemistry of reoxygenation injury , 1988, Critical care medicine.

[48]  Andrew P. Duchon,et al.  Oxygen free radical involvement in ischemia and reperfusion injury to brain , 1988, Neuroscience Letters.

[49]  D. Harman,et al.  The aging process. , 1981, Basic life sciences.

[50]  J. Downey.  Ischaemia-Reperfusion Injury; Current Research Status , 1988 .

[51]  J. Carlson,et al.  Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat , 1987, Mechanisms of Ageing and Development.

[52]  A. Stern,et al.  Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury , 1987, Journal of neurochemistry.

[53]  L. Battistin,et al.  Age Dependence of the Level of the Enzymes Involved in the Protection against Active Oxygen Species in the Rat Brain , 1987, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[54]  K. Kogure,et al.  Mechanism of Arachidonic Acid Liberation During Ischemia in Gerbil Cerebral Cortex , 1987, Journal of neurochemistry.

[55]  J. Kuhn,et al.  Ibuprofen improves survival and neurologic outcome after resuscitation from cardiac arrest. , 1986, Resuscitation.

[56]  P. Kochanek,et al.  Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. , 1986, Stroke.

[57]  J. McCord.  Superoxide radical: A likely link between reperfusion injury and inflammation , 1986 .

[58]  M. Höllwarth,et al.  Ischemia-reperfusion injury: role of oxygen-derived free radicals. , 1986, Acta physiologica Scandinavica. Supplementum.

[59]  B. Halliwell,et al.  Oxygen radicals and the nervous system , 1985, Trends in Neurosciences.

[60]  H. Kontos.  George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury. , 1985, Circulation research.

[61]  A. Hamberger,et al.  Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular Compartments , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[62]  H. Yasuda,et al.  Biphasic Liberation of Arachidonic and Stearic Acids During Cerebral Ischemia , 1985, Journal of neurochemistry.

[63]  A. Betz.  Identification of Hypoxanthine Transport and Xanthine Oxidase Activity in Brain Capillaries , 1985, Journal of neurochemistry.

[64]  J. McCord,et al.  Oxygen-derived free radicals in postischemic tissue injury. , 1985, The New England journal of medicine.

[65]  B. White,et al.  Iron chelation prevents tissue injury following ischemia , 1985 .

[66]  H. Benveniste,et al.  Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis , 1984, Journal of neurochemistry.

[67]  J. Vitorica,et al.  Age‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm , 1984, Journal of neurochemistry.

[68]  R J Jarrett,et al.  Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall study. , 1983, British medical journal.

[69]  Manning Feinleib,et al.  Obesity as an Independent Risk Factor for Cardiovascular Disease: A 26‐year Follow‐up of Participants in the Framingham Heart Study , 1983, Circulation.

[70]  S. Hamilton,et al.  Ischemic injury in the cat small intestine: Role of superoxide radicals , 1982 .

[71]  R. Egan,et al.  Prostaglandins, arachidonic acid, and inflammation. , 1980, Science.

[72]  B. Leibovitz,et al.  Aspects of free radical reactions in biological systems: aging. , 1980, Journal of gerontology.

[73]  E. Flamm,et al.  The free radical pathology and the microcirculation in the major central nervous system disorders. , 1980, Acta physiologica Scandinavica. Supplementum.

[74]  E. Flamm,et al.  Free radicals in cerebral ischemia. , 1978, Stroke.

[75]  W. Pryor.  CHAPTER 1 – The Role of Free Radical Reactions in Biological Systems , 1976 .