A Placebo‐Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa‐Induced Dyskinesia
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L. Defebvre | I. Rozenberg | O. Rascol | P. Maruff | J. Houeto | D. Berg | A. Ceballos-Baumann | F. Durif | E. Broussolle | A. Feigin | J. Corvol | T. Di Paolo | A. Espay | F. Stocchi | C. Geny | C. Trenkwalder | A. Storch | J. Azulay | J. Schwarz | P. Derkinderen | B. Gomez-Mancilla | G. Linazasoro | J. Sóvágó | C. Tranchant | K. Eggert | J. Jaeger | H. Hockey | A. Jakab | D. Feuerbach | Donald R. Johns | M. Gostkowski | M. Weiss | Lin Zhang | D. Johns
[1] W. Poewe,et al. Mavoglurant in Parkinson's patients with l‐Dopa‐induced dyskinesias: Two randomized phase 2 studies , 2016, Movement disorders : official journal of the Movement Disorder Society.
[2] D. Hoyer,et al. AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation , 2015, British journal of pharmacology.
[3] L. Grégoire,et al. AQW051, a novel and selective nicotinic acetylcholine receptor α7 partial agonist, reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys. , 2014, Parkinsonism & related disorders.
[4] S. Preskorn,et al. Normalizing Effects of EVP-6124, an Alpha-7 Nicotinic Partial Agonist, on Event-Related Potentials and Cognition: A Proof of Concept, Randomized Trial in Patients with Schizophrenia , 2014, Journal of psychiatric practice.
[5] M. Bencherif,et al. Nicotinic Receptor Agonists Reduce l-DOPA–Induced Dyskinesias in a Monkey Model of Parkinson's Disease , 2013, The Journal of Pharmacology and Experimental Therapeutics.
[6] J. Waring,et al. Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia , 2013, Alzheimer's & Dementia.
[7] F. Meneghello,et al. Morphometric evidence of neuroplastic effects induced by intensive cognitive stimulation in healthy ageing and in mild cognitive impairment , 2013, Alzheimer's & Dementia.
[8] J. Lieberman,et al. A Randomized Exploratory Trial of an Alpha-7 Nicotinic Receptor Agonist (TC-5619) for Cognitive Enhancement in Schizophrenia , 2013, Neuropsychopharmacology.
[9] K. Takata,et al. 3‐[(2,4‐dimethoxy)benzylidene]‐anabaseine dihydrochloride protects against 6‐hydroxydopamine‐induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats , 2013, Journal of neuroscience research.
[10] J. Nutt,et al. Which dyskinesia scale best detects treatment response? , 2013, Movement disorders : official journal of the Movement Disorder Society.
[11] Gary Maurice Dull,et al. Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. , 2012, Journal of medicinal chemistry.
[12] R. Barker,et al. Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines , 2012, Movement disorders : official journal of the Movement Disorder Society.
[13] D. Bertrand,et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors , 2012, Neuropharmacology.
[14] W. Poewe,et al. The Movement Disorder Society Evidence‐Based Medicine Review Update: Treatments for the non‐motor symptoms of Parkinson's disease , 2011, Movement disorders : official journal of the Movement Disorder Society.
[15] M. Quik,et al. Nicotinic receptor agonists decrease L-dopa-induced dyskinesias most effectively in partially lesioned parkinsonian rats , 2011, Neuropharmacology.
[16] R. Papke,et al. TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. , 2009, Biochemical pharmacology.
[17] M. Quik,et al. Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys , 2009, Journal of neurochemistry.
[18] D. Hoyer,et al. The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain , 2009, Neuropharmacology.
[19] M. Quik,et al. Continuous and Intermittent Nicotine Treatment Reduces l-3,4-Dihydroxyphenylalanine (l-DOPA)-Induced Dyskinesias in a Rat Model of Parkinson's Disease , 2008, Journal of Pharmacology and Experimental Therapeutics.
[20] D. D. Di Monte,et al. Nicotine reduces levodopa‐induced dyskinesias in lesioned monkeys , 2007, Annals of neurology.
[21] C. Goetz,et al. Levodopa‐induced dyskinesias , 2007, Movement disorders : official journal of the Movement Disorder Society.
[22] D. Hoyer,et al. JN403, in vitro characterization of a novel nicotinic acetylcholine receptor α7 selective agonist , 2007, Neuroscience Letters.
[23] P. Maruff,et al. Practice Effects Associated with the Repeated Assessment of Cognitive Function Using the CogState Battery at 10-minute, One Week and One Month Test-retest Intervals , 2006, Journal of clinical and experimental neuropsychology.
[24] M. O'Neill,et al. Nicotine, but neither the α4β2 ligand RJR2403 nor an α7 nAChR subtype selective agonist, protects against a partial 6-hydroxydopamine lesion of the rat median forebrain bundle , 2006, Neuropharmacology.
[25] J. Langston,et al. Chronic oral nicotine treatment protects against striatal degeneration in MPTP‐treated primates , 2006, Journal of neurochemistry.
[26] Robert Freedman,et al. Proof-of-Concept Trial of an α7 Nicotinic Agonist in Schizophrenia , 2006 .
[27] J. Langston,et al. Chronic Oral Nicotine Normalizes Dopaminergic Function and Synaptic Plasticity in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Primates , 2006, The Journal of Neuroscience.
[28] M. Hajós,et al. The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats , 2005, Journal of Pharmacology and Experimental Therapeutics.
[29] Laurent Gerbaud,et al. Impact of the motor complications of Parkinson's disease on the quality of life , 2005, Movement disorders : official journal of the Movement Disorder Society.
[30] A. Burnett,et al. Safety, Pharmacokinetics, and Effects on Cognitive Function of Multiple Doses of GTS-21 in Healthy, Male Volunteers* , 2003, Neuropsychopharmacology.
[31] M. Muenter,et al. Frequency of levodopa‐related dyskinesias and motor fluctuations as estimated from the cumulative literature , 2001, Movement disorders : official journal of the Movement Disorder Society.
[32] J. Drago,et al. Dose‐related neuroprotective effects of chronic nicotine in 6‐hydroxydopamine treated rats, and loss of neuroprotection in α4 nicotinic receptor subunit knockout mice , 2001, British journal of pharmacology.
[33] E. Hirsch,et al. Nicotine, but not cotinine, partially protects dopaminergic neurons against MPTP-induced degeneration in mice , 2001, Brain Research.
[34] W. J. Goodwin. US Department of Health, Education and Welfare, National Institutes of Health: Regional Primate Research Centers. The Creation of a Program. Bethesda, Md. 1968. 67 pp., 2 tables. Obtainable at no cost. , 1972, Journal of Medical Primatology.
[35] W. Oertel,et al. The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice. , 2013, Journal of Parkinson's disease.
[36] 鈴木 秀一郎. 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats , 2013 .
[37] M. O'Neill,et al. Nicotine, but neither the alpha4beta2 ligand RJR2403 nor an alpha7 nAChR subtype selective agonist, protects against a partial 6-hydroxydopamine lesion of the rat median forebrain bundle. , 2006, Neuropharmacology.
[38] R. Freedman,et al. Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. , 2006, Archives of general psychiatry.
[39] N. Higdon,et al. The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. , 2005, The Journal of pharmacology and experimental therapeutics.
[40] Evaluation of dyskinesias in a pilot, randomized, placebo-controlled trial of remacemide in advanced Parkinson disease. , 2001, Archives of neurology.
[41] R. Papke,et al. Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes. , 1995, Molecular pharmacology.
[42] Y. Agid,et al. Levodopa‐induced dyskinesias in Parkinson's disease phenomenology and pathophysiology , 1994, Movement disorders : official journal of the Movement Disorder Society.
[43] F. Goodwin. From the Alcohol, Drug Abuse, and Mental Health Administration. , 1991, JAMA.
[44] S. Fahn. Members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale , 1987 .
[45] Diane C. Tsai. Recent Developments in Parkinson's Disease , 1986, The Yale Journal of Biology and Medicine.
[46] R. Hurst,et al. The Selective Α 7 Nicotinic Acetylcholine Receptor Agonist Pnu-282987 Enhances Gabaergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats , 2022 .