Hepatotoxicity due to mitochondrial dysfunction

[1]  D. Pessayre,et al.  Withdrawal of life support, altruistic suicide, fratricidal killing and euthanasia by lymphocytes: different forms of drug-induced hepatic apoptosis. , 1999, Journal of hepatology.

[2]  D. Pessayre,et al.  An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice. , 1999, Gastroenterology.

[3]  J. Ibdah,et al.  A Fetal Fatty-Acid Oxidation Disorder as a Cause of Liver Disease in Pregnant Women , 1999 .

[4]  D. Bogenhagen Repair of mtDNA in vertebrates. , 1999, American journal of human genetics.

[5]  M. Saraste Oxidative phosphorylation at the fin de siècle. , 1999, Science.

[6]  D. Brenner,et al.  The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. , 1998, Biochimica et biophysica acta.

[7]  G. Kroemer,et al.  Mitochondria as regulators of apoptosis: doubt no more. , 1998, Biochimica et biophysica acta.

[8]  C. Day,et al.  Hepatic steatosis: Innocent bystander or guilty party? , 1998, Hepatology.

[9]  D. Pessayre,et al.  Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. , 1998, Gastroenterology.

[10]  D. Pessayre,et al.  Diterpenoids from germander, an herbal medicine, induce apoptosis in isolated rat hepatocytes. , 1997, Gastroenterology.

[11]  D. Pessayre,et al.  Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease. , 1997, Gastroenterology.

[12]  D. Pessayre,et al.  Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients. , 1997, Journal of hepatology.

[13]  D. Pessayre,et al.  Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation. , 1997, The American journal of physiology.

[14]  S. Krähenbühl,et al.  Fulminant liver failure in association with the emetic toxin of Bacillus cereus. , 1997, The New England journal of medicine.

[15]  S. Dimauro,et al.  Mitochondrial DNA Mutations and Pathogenesis , 1997, Journal of bioenergetics and biomembranes.

[16]  D. Pessayre,et al.  Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. , 1996, The Journal of clinical investigation.

[17]  D. Pessayre,et al.  Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction. , 1996, Gastroenterology.

[18]  G. Kroemer,et al.  Mitochondrial control of nuclear apoptosis , 1996, The Journal of experimental medicine.

[19]  D. Pessayre,et al.  Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice. , 1996, Journal of hepatology.

[20]  M. Dalakas,et al.  Mitochondrial toxicity of antiviral drugs , 1995, Nature Medicine.

[21]  G. Gores,et al.  Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. , 1995, The Journal of pharmacology and experimental therapeutics.

[22]  B. Ames,et al.  Oxidative damage and mitochondrial decay in aging. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[23]  D. Pessayre,et al.  Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen. , 1994, The Journal of pharmacology and experimental therapeutics.

[24]  D. Pessayre,et al.  Toxicity of the antiandrogen flutamide in isolated rat hepatocytes. , 1994, The Journal of pharmacology and experimental therapeutics.

[25]  A. Guillouzo,et al.  Inhibition by perhexiline of oxidative phosphorylation and the β‐oxidation of fatty acids: Possible role in pseudoalcoholic liver lesions , 1994, Hepatology.

[26]  K. Kassahun,et al.  In vivo formation of the thiol conjugates of reactive metabolites of 4-ene VPA and its analog 4-pentenoic acid. , 1993, Drug metabolism and disposition: the biological fate of chemicals.

[27]  D. Pessayre,et al.  Decreased mitochondrial oxidation of fatty acids in pregnant mice: Possible relevance to development of acute fatty liver of pregnancy , 1993, Hepatology.

[28]  D. Pessayre,et al.  Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers. , 1993, Gut.

[29]  D. Pessayre,et al.  Inhibition by salicylic acid of the activation and thus oxidation of long chain fatty acids. Possible role in the development of Reye's syndrome. , 1991, The Journal of pharmacology and experimental therapeutics.

[30]  G. Labbe,et al.  Effects of various tetracycline derivatives on in vitro and in vivo beta-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in mice. , 1991, Biochemical pharmacology.

[31]  G. Labbe,et al.  Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. , 1990, The Journal of pharmacology and experimental therapeutics.

[32]  D. Pessayre,et al.  Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II. , 1990, The Journal of pharmacology and experimental therapeutics.

[33]  B. Shan,et al.  Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon‐mediated responses. , 1990, The EMBO journal.

[34]  G. Labbe,et al.  Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial beta-oxidation of fatty acids. , 1990, The Journal of pharmacology and experimental therapeutics.

[35]  G. Labbe,et al.  Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice. , 1989, Biochemical pharmacology.

[36]  G. Labbe,et al.  Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. , 1988, The Journal of pharmacology and experimental therapeutics.

[37]  G. Labbe,et al.  Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: Possible role in microvesicular steatosis induced by this antibiotic , 1988, Hepatology.

[38]  G. Labbe,et al.  Inhibition of mitochondrial beta-oxidation of fatty acids by pirprofen. Role in microvesicular steatosis due to this nonsteroidal anti-inflammatory drug. , 1987, The Journal of pharmacology and experimental therapeutics.

[39]  G. Granneman,et al.  The Hepatotoxicity of Valproic Acid and Its Metabolites in Rats. I. Toxicologic, Biochemical and Histopathologic Studies , 1984, Hepatology.

[40]  V. Bhalla,et al.  inhibition in , 2005 .

[41]  D. Pessayre,et al.  Hepatocyte Apoptosis Triggered by Natural Substances (Cytokines, Other Endogenous Molecules and Foreign Toxins) , 2000 .

[42]  E. Zafrani,et al.  Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion. , 1999, Journal of hepatology.

[43]  D. Pessayre,et al.  Microvesicular steatosis and steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation. , 1997, Journal of hepatology.

[44]  D. Pessayre Role of reactive metabolites in drug-induced hepatitis. , 1995, Journal of hepatology.

[45]  D. Pessayre,et al.  Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. , 1995, Pharmacology & therapeutics.

[46]  D. Pessayre,et al.  Effects of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancy. , 1995, The American journal of physiology.

[47]  A. Rötig,et al.  Hepatic mitochondrial DNA deletion in alcoholics: association with microvesicular steatosis. , 1995, Gastroenterology.