The role of nuclear import and export in influenza virus infection.

Infection with influenza virus involves a complex series of nuclear import and export events. Early in infection, incoming viral ribonucleoproteins (vRNPs) are imported into the nucleus. Later, viral transcripts are exported from the nucleus, newly synthesized structural proteins are transported back into the nucleus and, finally, newly assembled vRNPs are exported. All these import and export steps, and, in particular, the bidirectional traffic of vRNPs rely on the transport machinery of the cell, but are regulated both by viral and cellular factors. The viral MI protein serves as the master organizer in determining the directionality of vRNP transport.

[1]  S. Adam,et al.  The importance of importin , 1995 .

[2]  Z. Ye,et al.  Transcription-inhibition and RNA-binding domains of influenza A virus matrix protein mapped with anti-idiotypic antibodies and synthetic peptides , 1989, Journal of virology.

[3]  Z. Ye,et al.  Nucleus-targeting domain of the matrix protein (M1) of influenza virus , 1995, Journal of virology.

[4]  R. Lamb,et al.  Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions , 1988, Journal of virology.

[5]  A. Hay,et al.  Structural characteristics of the M2 protein of influenza a viruses: Evidence that it forms a tetrameric channe , 1991, Virology.

[6]  J. Finch,et al.  Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA? , 1983, Cell.

[7]  G. K. Vorkunova,et al.  Influenza virus uncoating in infected cells and effect of rimantadine. , 1982, The Journal of general virology.

[8]  C. Scholtissek,et al.  Influenza A virus late mRNAs are specifically retained in the nucleus in the presence of a methyltransferase or a protein kinase inhibitor. , 1994, Virology.

[9]  O. Zhirnov.  Isolation of matrix protein M1 from influenza viruses by acid-dependent extraction with nonionic detergent. , 1992, Virology.

[10]  A. Helenius,et al.  Virus Entry into Animal Cells , 1989, Advances in Virus Research.

[11]  R. Krug,et al.  The Influenza Viruses , 2011, The Viruses.

[12]  K. Martin,et al.  Nuclear transport of influenza virus ribonucleoproteins: The viral matrix protein (M1) promotes export and inhibits import , 1991, Cell.

[13]  I. Schulze.  Structure of the Influenza Virion , 1973 .

[14]  P. Duesberg,et al.  Structure of the Ribonucleoprotein of Influenza Virus , 1972, Journal of virology.

[15]  R. Krug,et al.  The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. , 1994, Genes & development.

[16]  H. Klenk,et al.  Influenza virus proteins. I. Analysis of polypeptides of the virion and identification of spike glycoproteins. , 1970, Virology.

[17]  A. Ishihama,et al.  Identification of the RNA polymerase-binding site on genome RNA of influenza virus. , 1987, Journal of biochemistry.

[18]  A. Beloso,et al.  Influenza virus NS1 protein inhibits pre‐mRNA splicing and blocks mRNA nucleocytoplasmic transport. , 1994, The EMBO journal.

[19]  J. Davey,et al.  Identification of the sequence responsible for the nuclear accumulation of the influenza virus nucleoprotein in Xenopus oocytes , 1985, Cell.

[20]  P. Palese,et al.  NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. , 1995, Virology.

[21]  J. Skehel,et al.  The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. , 1987, Annual review of biochemistry.

[22]  R. Gingery.  Properties of maize chlorotic dwarf virus and its ribonucleic acid. , 1976, Virology.

[23]  J. Skehel,et al.  The molecular basis of the specific anti‐influenza action of amantadine. , 1985, The EMBO journal.

[24]  G. Blobel,et al.  Nuclear Import of Influenza Virus RNA Can Be Mediated by Viral Nucleoprotein and Transport Factors Required for Protein Import (*) , 1995, The Journal of Biological Chemistry.

[25]  K. Fraser.  Immunofluorescence of abortive and complete infections by influenza A virus in hamster BHK21 cells and mouse L cells. , 1967, The Journal of general virology.

[26]  L. Gerace,et al.  Nuclear export signals and the fast track to the cytoplasm , 1995, Cell.

[27]  R. Krug,et al.  The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A) , 1994, Journal of virology.

[28]  Lawrence H. Pinto,et al.  Influenza virus M2 protein has ion channel activity , 1992, Cell.

[29]  A Helenius,et al.  Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus , 1995, Journal of virology.

[30]  R. Ruigrok,et al.  Electron microscopy of the influenza virus submembranal structure. , 1989, Virology.

[31]  W. J. Bean,et al.  Composition of the helical internal components of influenza virus as revealed by immunogold labeling/electron microscopy. , 1992, Virology.

[32]  H. Ochiai,et al.  Inhibitory effect of protein kinase C inhibitor on the replication of influenza type A virus. , 1990, The Journal of general virology.

[33]  D. Nayak,et al.  Nuclear retention of M1 protein in a temperature-sensitive mutant of influenza (A/WSN/33) virus does not affect nuclear export of viral ribonucleoproteins , 1992, Journal of virology.

[34]  B. Daneholt,et al.  The Balbiani ring particle: a model for the assembly and export of RNPs from the nucleus? , 1993, Trends in cell biology.

[35]  R. Krug,et al.  Influenza virus gene expression: control mechanisms at early and late times of infection and nuclear-cytoplasmic transport of virus-specific RNAs , 1987, Journal of virology.

[36]  A Helenius,et al.  Transport of incoming influenza virus nucleocapsids into the nucleus , 1991, Journal of virology.

[37]  R. Webster,et al.  Localization of RNA polymerases on influenza viral ribonucleoproteins by immunogold labeling. , 1988, Virology.

[38]  A. Helenius,et al.  Nuclear import of microinjected influenza virus ribonucleoproteins. , 1994, Virology.

[39]  S. Cusack,et al.  Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent. , 1994, The EMBO journal.

[40]  G. Air,et al.  Data for Drug Design. (Book Reviews: Use of X-Ray Crystallography in the Design of Antiviral Agents.) , 1990 .

[41]  C. Feldherr,et al.  Movement of a karyophilic protein through the nuclear pores of oocytes , 1984, The Journal of cell biology.

[42]  G Rautmann,et al.  Evidence that HIV‐1 Rev directly promotes the nuclear export of unspliced RNA. , 1994, The EMBO journal.

[43]  A. Kendal,et al.  Role of the M2 protein in influenza virus membrane fusion: effects of amantadine and monensin on fusion kinetics. , 1993, Virology.

[44]  A. Ishihama,et al.  Molecular assembly of influenza virus: association of the NS2 protein with virion matrix. , 1993, Virology.