Omega-3 fatty acids EPA and DHA: health benefits throughout life.

Omega-3 [(n-3)] fatty acids have been linked to healthy aging throughout life. Recently, fish-derived omega-3 fatty acids EPA and DHA have been associated with fetal development, cardiovascular function, and Alzheimer's disease. However, because our bodies do not efficiently produce some omega-3 fatty acids from marine sources, it is necessary to obtain adequate amounts through fish and fish-oil products. Studies have shown that EPA and DHA are important for proper fetal development, including neuronal, retinal, and immune function. EPA and DHA may affect many aspects of cardiovascular function including inflammation, peripheral artery disease, major coronary events, and anticoagulation. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in those with very mild Alzheimer's disease.

[1]  J. Geleijnse,et al.  n-3 fatty acids and cardiovascular events after myocardial infarction. , 2010, The New England journal of medicine.

[2]  Y. Matsuzawa,et al.  Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS). , 2009, Atherosclerosis.

[3]  Michael Weiner,et al.  Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. , 2010, JAMA.

[4]  B. Strandvik,et al.  Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents. , 2010, Atherosclerosis.

[5]  E. Ah-Sing,et al.  Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. , 2005, Journal of lipid research.

[6]  D. Arduini,et al.  Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion. , 2009, Fertility and sterility.

[7]  B. Mackey,et al.  DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men. , 2009, The Journal of nutrition.

[8]  Charles N. Serhan,et al.  Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators , 2008, Nature Reviews Immunology.

[9]  M. Tierney,et al.  Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment , 2000, Lipids.

[10]  R. Mensink,et al.  Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. , 2005, Journal of lipid research.

[11]  G. Steinbeck,et al.  OMEGA, a Randomized, Placebo-Controlled Trial to Test the Effect of Highly Purified Omega-3 Fatty Acids on Top of Modern Guideline-Adjusted Therapy After Myocardial Infarction , 2010, Circulation.

[12]  M. Garg,et al.  Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals. , 2009, Atherosclerosis.

[13]  D. Reeds,et al.  Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. , 2011, The American journal of clinical nutrition.

[14]  R. Kitz,et al.  Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults. , 2007, Nutrition.

[15]  M. Chiariello,et al.  Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function. , 2008, Clinical nutrition.

[16]  M. Klebanoff,et al.  Omega-3 Fatty Acid Supplementation to Prevent Recurrent Preterm Birth: A Randomized Controlled Trial , 2010, Obstetrics and gynecology.

[17]  T. Henriksen,et al.  Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. , 2008, The American journal of clinical nutrition.

[18]  R. Kornowski,et al.  Treatment of aspirin-resistant patients with omega-3 fatty acids versus aspirin dose escalation. , 2010, Journal of the American College of Cardiology.

[19]  B. Meyer,et al.  Effects of Seal Oil and Tuna-Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjects , 2010, Lipids.

[20]  T. Weber,et al.  Duration of pregnancy in relation to fish oil supplementation and habitual fish intake: a randomised clinical trial with fish oil , 2007, European Journal of Clinical Nutrition.

[21]  Y. Matsuzawa,et al.  Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis , 2007, The Lancet.

[22]  C. Pariante,et al.  Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. , 2008, The Journal of clinical psychiatry.

[23]  C. Dawczynski,et al.  n-3 LC-PUFA-enriched dairy products are able to reduce cardiovascular risk factors: a double-blind, cross-over study. , 2010, Clinical nutrition.

[24]  Shih-Yi Huang,et al.  The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study , 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[25]  Gissi-Hf Investigators.  Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial , 2008, The Lancet.

[26]  J. Palmblad,et al.  Omega‐3 Fatty Acid Supplementation Effects on Weight and Appetite in Patients with Alzheimer's Disease: The Omega‐3 Alzheimer's Disease Study , 2009, Journal of the American Geriatrics Society.

[27]  K. Wittkowski,et al.  Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults. , 2011, The Journal of nutrition.

[28]  O. Harel,et al.  Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo. , 2007, The American journal of clinical nutrition.

[29]  W. Piwowarska,et al.  Effects of polyunsaturated omega-3 fatty acids on responsiveness to dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: the OMEGA-PCI (OMEGA-3 fatty acids after pci to modify responsiveness to dual antiplatelet therapy) study. , 2010, Journal of the American College of Cardiology.

[30]  D. Doherty,et al.  The Effects of Fish Oil Supplementation in Pregnancy on Breast Milk Fatty Acid Composition Over the Course of Lactation: A Randomized Controlled Trial , 2007, Pediatric Research.

[31]  G. Ferns,et al.  Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity , 2009, Acta cardiologica.

[32]  J. Palmblad,et al.  Omega‐3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms , 2008, International journal of geriatric psychiatry.

[33]  J. Dartigues,et al.  Commentary on “A roadmap for the prevention of dementia II. Leon Thal Symposium 2008.” The Multidomain Alzheimer Preventive Trial (MAPT): A new approach to the prevention of Alzheimer's disease , 2009, Alzheimer's & Dementia.

[34]  R. Bloomer,et al.  Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study , 2009, Lipids in Health and Disease.

[35]  C. Drevon,et al.  Effect of Supplementing Pregnant and Lactating Mothers With n-3 Very-Long-Chain Fatty Acids on Children's IQ and Body Mass Index at 7 Years of Age , 2008, Pediatrics.

[36]  Takashi Morihara,et al.  A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model , 2005, The Journal of Neuroscience.

[37]  Y. Matsuzawa,et al.  Preventive effects of eicosapentaenoic acid on coronary artery disease in patients with peripheral artery disease. , 2010, Circulation journal : official journal of the Japanese Circulation Society.

[38]  Yaakov Stern,et al.  Food combination and Alzheimer disease risk: a protective diet. , 2010, Archives of neurology.

[39]  P. Nathanielsz,et al.  Omega-3 fatty acids and decidual cell prostaglandin production in response to the inflammatory cytokine IL-1β , 2006 .

[40]  M. Fredriksson,et al.  Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy , 2009, Acta paediatrica.

[41]  L. D. de Groot,et al.  Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. , 2009, The American journal of clinical nutrition.

[42]  E. Hoster,et al.  Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial. , 2007, The American journal of clinical nutrition.

[43]  D. Leaf,et al.  The Effect of Lean Fish Consumption on Triglyceride Levels , 2009, The Physician and sportsmedicine.

[44]  B. Lawlor,et al.  Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study , 2003, British Journal of Nutrition.

[45]  P. Calder,et al.  Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability. , 2010, Atherosclerosis.

[46]  L. Tavazzi,et al.  Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione , 2002 .

[47]  Lars-Olof Wahlund,et al.  Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. , 2006, Archives of neurology.

[48]  Lawrence J Appel,et al.  Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[49]  S. Prescott,et al.  Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial , 2006, Archives of Disease in Childhood Fetal and Neonatal Edition.

[50]  J. Palmblad,et al.  Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer’s Disease: The OmegAD Study , 2009, Dementia and Geriatric Cognitive Disorders.

[51]  R. Martorell,et al.  Effects of Docosahexaenoic Acid Supplementation During Pregnancy on Gestational Age and Size at Birth: Randomized, Double-Blind, Placebo-Controlled Trial in Mexico , 2010, Food and nutrition bulletin.

[52]  P. Rzehak,et al.  Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. , 2008, The Journal of allergy and clinical immunology.

[53]  R. Gibson,et al.  Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. , 2010, JAMA.

[54]  J. Palmblad,et al.  Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. , 2008, The American journal of clinical nutrition.

[55]  Y. Matsuzawa,et al.  Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). , 2008, Atherosclerosis.