Enhancing the performance of Mg-based implant materials by introducing basal plane stacking faults.

One of the keys to allowing Mg alloys to serve as biodegradable materials is how to balance their degradation behaviours and mechanical properties in physiological environment. In this study, a novel Mg-6Ho-0.5Zn alloy (wt%) containing profuse basal plane stacking faults (SFs) is prepared. This newly-developed alloy with SFs exhibiting uniform corrosion behaviour, low corrosion rate and high mechanical properties, as compared to the classic Mg-Ho based alloys (Mg-6Ho and Mg-6Ho-1.5Zn). Furthermore, the Mg-6Ho-0.5Zn alloy shows no significant toxicity to Saos-2 cells. An original uniform corrosion mechanism is proposed by combining the special defect structure, orientation of SFs and promptly effective corrosion film. The development of the new microstructure for Mg-Ho based alloys with desirable corrosion performance has important implications in developing novel degradable Mg-based implant materials.

[1]  Yunfei Ding,et al.  Effects of zirconium and strontium on the biocorrosion of Mg-Zr-Sr alloys for biodegradable implant applications. , 2015, Journal of materials chemistry. B.

[2]  M. Dargusch,et al.  Review of Recent Developments in the Field of Magnesium Corrosion , 2015 .

[3]  C. Dong,et al.  Effect of heat treatment on the corrosion resistance and mechanical properties of an as-forged Mg–Zn–Y–Zr alloy , 2015 .

[4]  Shervin Eslami Harandi,et al.  Corrosion fatigue fracture of magnesium alloys in bioimplant applications: A review , 2015 .

[5]  Jörg F. Löffler,et al.  Assessing the degradation performance of ultrahigh-purity magnesium in vitro and in vivo , 2015 .

[6]  I. Jones,et al.  The role of β1′ precipitates in the bio-corrosion performance of Mg–3Zn in simulated body fluid , 2014 .

[7]  Yujuan Wu,et al.  Uniform corrosion behavior of GZ51K alloy with long period stacking ordered structure for biomedical application , 2014 .

[8]  Zhigang Xu,et al.  Recent advances on the development of magnesium alloys for biodegradable implants. , 2014, Acta biomaterialia.

[9]  T. Woodfield,et al.  Magnesium biomaterials for orthopedic application: a review from a biological perspective. , 2014, Journal of biomedical materials research. Part B, Applied biomaterials.

[10]  Zhao-hui Wang,et al.  Microstructure, texture and mechanical properties of as-extruded Mg–Zn–Er alloys containing W-phase , 2014 .

[11]  W. Kim,et al.  Enhancement of mechanical properties and corrosion resistance of Mg–Ca alloys through microstructural refinement by indirect extrusion , 2014 .

[12]  Q. Peng,et al.  Effect of microalloying with rare-earth on recrystallization behaviour and damping properties of Mg sheets , 2014 .

[13]  Q. Peng,et al.  Degradation behavior of Mg-based biomaterials containing different long-period stacking ordered phases , 2014, Scientific Reports.

[14]  Q. Peng,et al.  Influence of biocorrosion on microstructure and mechanical properties of deformed Mg-Y-Er-Zn biomaterial containing 18R-LPSO phase. , 2013, Journal of the mechanical behavior of biomedical materials.

[15]  P. Kumta,et al.  In vitro and in vivo corrosion, cytocompatibility and mechanical properties of biodegradable Mg-Y-Ca-Zr alloys as implant materials. , 2013, Acta biomaterialia.

[16]  Karl Ulrich Kainer,et al.  Element distribution in the corrosion layer and cytotoxicity of alloy Mg-10Dy during in vitro biodegradation. , 2013, Acta biomaterialia.

[17]  M. Leeflang,et al.  Mechanical property, biocorrosion and in vitro biocompatibility evaluations of Mg-Li-(Al)-(RE) alloys for future cardiovascular stent application. , 2013, Acta biomaterialia.

[18]  Karl Ulrich Kainer,et al.  Microstructure, mechanical and corrosion properties of Mg-Dy-Gd-Zr alloys for medical applications. , 2013, Acta biomaterialia.

[19]  Andrej Atrens,et al.  The in vivo and in vitro corrosion of high-purity magnesium and magnesium alloys WZ21 and AZ91 , 2013 .

[20]  Ke Yang,et al.  Biodegradable Materials for Bone Repairs: A Review , 2013 .

[21]  Yufeng Zheng,et al.  Novel Magnesium Alloys Developed for Biomedical Application: A Review , 2013 .

[22]  C. Koch,et al.  Ultrastrong Mg Alloy via Nano-spaced Stacking Faults , 2013 .

[23]  Yangde Li,et al.  Microstructure, mechanical properties, in vitro degradation and cytotoxicity evaluations of Mg-1.5Y-1.2Zn-0.44Zr alloys for biodegradable metallic implants. , 2013, Materials science & engineering. C, Materials for biological applications.

[24]  J. Allen,et al.  A study of a biodegradable Mg-3Sc-3Y alloy and the effect of self-passivation on the in vitro degradation. , 2013, Acta biomaterialia.

[25]  Xu Zhao,et al.  Biodegradable Mg-Zn-Y alloys with long-period stacking ordered structure: optimization for mechanical properties. , 2013, Journal of the mechanical behavior of biomedical materials.

[26]  Guohua Wu,et al.  A novel biodegradable Mg–Nd–Zn–Zr alloy with uniform corrosion behavior in artificial plasma , 2012 .

[27]  Yujuan Wu,et al.  Biocorrosion behavior and cytotoxicity of a Mg–Gd–Zn–Zr alloy with long period stacking ordered structure , 2012 .

[28]  J. Seitz,et al.  Characterization of MgNd2 alloy for potential applications in bioresorbable implantable devices. , 2012, Acta biomaterialia.

[29]  Yao Jiang,et al.  In vitro response of chondrocytes to a biodegradable Mg–Nd–Zn–Zr alloy , 2012 .

[30]  Yufeng Zheng,et al.  In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal. , 2012, Acta biomaterialia.

[31]  Q. Peng,et al.  Effects of backward extrusion on mechanical and degradation properties of Mg-Zn biomaterial. , 2012, Journal of the mechanical behavior of biomedical materials.

[32]  V. Březina,et al.  Microstructure, corrosion resistance and cytocompatibility of Mg–5Y–4Rare Earth–0.5Zr (WE54) alloy , 2012 .

[33]  Tim Woodfield,et al.  Magnesium alloys: predicting in vivo corrosion with in vitro immersion testing. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[34]  Q. Peng,et al.  Mechanical and corrosion properties of binary Mg–Dy alloys for medical applications , 2011 .

[35]  Jun Wang,et al.  Microstructure and mechanical properties of Mg-xY-1.5MM-0.4Zr alloys , 2011 .

[36]  A. Atrens,et al.  An innovative specimen configuration for the study of Mg corrosion , 2011 .

[37]  R. Pinto,et al.  The corrosion behaviour of rare-earth containing magnesium alloys in borate buffer solution , 2011 .

[38]  M. Liu,et al.  The influence of yttrium (Y) on the corrosion of Mg–Y binary alloys , 2010 .

[39]  Limin Wang,et al.  Microstructures and mechanical properties of Mg-10Ho-0.6Zr-xNd alloys , 2010 .

[40]  Frank Witte,et al.  Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines. , 2010, Acta biomaterialia.

[41]  M. Störmer,et al.  Magnesium alloys as implant materials--principles of property design for Mg-RE alloys. , 2010, Acta biomaterialia.

[42]  P. Uggowitzer,et al.  On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg-Y-Zn alloys. , 2010, Acta biomaterialia.

[43]  D. Mantovani,et al.  Developments in metallic biodegradable stents. , 2010, Acta biomaterialia.

[44]  W. Zhou,et al.  Effect of heat treatment on corrosion behaviour of magnesium alloy AZ91D in simulated body fluid , 2010 .

[45]  Andrej Atrens,et al.  Measurement of the corrosion rate of magnesium alloys using Tafel extrapolation , 2010 .

[46]  Yang Song,et al.  Research on an Mg-Zn alloy as a degradable biomaterial. , 2010, Acta biomaterialia.

[47]  Jian Meng,et al.  Effect of the long periodic stacking structure and W-phase on the microstructures and mechanical properties of the Mg-8Gd-xZn-0.4Zr alloys , 2010 .

[48]  Qiuming Peng,et al.  Preparation and properties of high purity Mg-Y biomaterials. , 2010, Biomaterials.

[49]  G. Song,et al.  An exploratory study of the corrosion of Mg alloys during interrupted salt spray testing , 2009 .

[50]  J. Meng,et al.  Effect of yttrium-rich misch metal on the microstructures, mechanical properties and corrosion behavior of die cast AZ91 alloy , 2009 .

[51]  M. Liu,et al.  Calculated phase diagrams and the corrosion of die-cast Mg–Al alloys , 2009 .

[52]  Y. Kawamura,et al.  Relation between corrosion behavior and microstructure of Mg–Zn–Y alloys prepared by rapid solidification at various cooling rates , 2009 .

[53]  Yufeng Zheng,et al.  In vitro corrosion and biocompatibility of binary magnesium alloys. , 2009, Biomaterials.

[54]  Frank Witte,et al.  Degradable biomaterials based on magnesium corrosion , 2008 .

[55]  R. Raman,et al.  In vitro degradation and mechanical integrity of calcium-containing magnesium alloys in modified-simulated body fluid. , 2008, Biomaterials.

[56]  Yufeng Zheng,et al.  The development of binary Mg-Ca alloys for use as biodegradable materials within bone. , 2008, Biomaterials.

[57]  M. Nishijima,et al.  Formation of 14H long period stacking ordered structure and profuse stacking faults in Mg–Zn–Gd alloys during isothermal aging at high temperature , 2007 .

[58]  Guang-Ling Song,et al.  Control of biodegradation of biocompatable magnesium alloys , 2007 .

[59]  Sirong Yu,et al.  Effect of cerium addition on microstructure and corrosion resistance of die cast AZ91 magnesium alloy , 2007 .

[60]  Ping Zhang,et al.  Effect of Long-Term Intake of Y3+ in Drinking Water on Gene Expression in Brains of Rats , 2006 .

[61]  Frank Witte,et al.  In vitro and in vivo corrosion measurements of magnesium alloys. , 2006, Biomaterials.

[62]  Alexis M Pietak,et al.  Magnesium and its alloys as orthopedic biomaterials: a review. , 2006, Biomaterials.

[63]  F. Gan,et al.  Improvement of corrosion resistance of AZ91D magnesium alloy by holmium addition , 2006 .

[64]  G. Song,et al.  Understanding Magnesium Corrosion—A Framework for Improved Alloy Performance , 2003 .

[65]  Y. Li,et al.  Correlation between the corrosion behavior and corrosion films formed on the surfaces of Mg82−xNi18Ndx (x=0, 5, 15) amorphous alloys , 2001 .

[66]  T. Yoshida,et al.  Plastic deformation and hardness in Mg–Zn–(Y,Ho) icosahedral quasicrystals , 2000 .

[67]  G. Song,et al.  Corrosion mechanisms of magnesium alloys , 1999 .