Expansion of Transdifferentiated Human Hepatocytes in a Serum-Free Microcarrier Culture System

[1]  W. Liu,et al.  The role of insulin in transdifferentiated hepatocyte proliferation and function in serum‐free medium , 2019, Journal of cellular and molecular medicine.

[2]  W. Tan,et al.  A serum-free medium suitable for maintaining cell morphology and liver-specific function in induced human hepatocytes , 2019, Cytotechnology.

[3]  Zhihong Wu,et al.  Porous chitosan microspheres as microcarriers for 3D cell culture. , 2018, Carbohydrate polymers.

[4]  Q. Lv,et al.  Three-dimensional coculture of primary hepatocytes and stellate cells in silk scaffold improves hepatic morphology and functionality in vitro. , 2018, Journal of biomedical materials research. Part A.

[5]  Marta M. Silva,et al.  Three‐dimensional co‐culture of human hepatocytes and mesenchymal stem cells: improved functionality in long‐term bioreactor cultures , 2017, Journal of tissue engineering and regenerative medicine.

[6]  S. Habib,et al.  Drug-Induced Acute Liver Failure. , 2017, Clinics in liver disease.

[7]  R. Moreau,et al.  Acute-on-chronic liver failure: an update , 2017, Gut.

[8]  R. Jalan,et al.  Extracorporeal liver support devices for listed patients , 2016, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[9]  C. Hewitt,et al.  Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms , 2016 .

[10]  L. Hui,et al.  Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes , 2016, Cell Research.

[11]  Ying Zhang,et al.  Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. , 2014, Cell stem cell.

[12]  Igor M. Sauer,et al.  Liver support strategies: cutting-edge technologies , 2014, Nature Reviews Gastroenterology &Hepatology.

[13]  G. Gstraunthaler,et al.  A plea to reduce or replace fetal bovine serum in cell culture media , 2013, Cytotechnology.

[14]  Lan-juan Li,et al.  Advances in cell sources of hepatocytes for bioartificial liver. , 2012, Hepatobiliary & pancreatic diseases international : HBPD INT.

[15]  Yitao Ding,et al.  Systematic review: extracorporeal bio-artificial liver-support system for liver failure , 2012, Hepatology International.

[16]  L. Hui,et al.  Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors , 2011, Nature.

[17]  C. Hewitt,et al.  Expansion of human mesenchymal stem cells on microcarriers , 2011, Biotechnology Letters.

[18]  M. Mel,et al.  Production of Newcastle Disease Virus by Vero Cells Grown on Cytodex 1 Microcarriers in a 2-Litre Stirred Tank Bioreactor , 2010, Journal of biomedicine & biotechnology.

[19]  G Gstraunthaler,et al.  Optimization of chemically defined cell culture media--replacing fetal bovine serum in mammalian in vitro methods. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[20]  James F. Schumacher,et al.  Engineering high-density endothelial cell monolayers on soft substrates. , 2009, Acta biomaterialia.

[21]  Cheng-bo Yu,et al.  Progress in bioreactors of bioartificial livers. , 2009, Hepatobiliary & pancreatic diseases international : HBPD INT.

[22]  Mario Jolicoeur,et al.  Chondrocytes cultured in stirred suspension with serum-free medium containing pluronic-68 aggregate and proliferate while maintaining their differentiated phenotype. , 2009, Tissue engineering. Part A.

[23]  Tiago G Fernandes,et al.  Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system. , 2007, Journal of biotechnology.

[24]  이남준,et al.  Optimal Number of Hepatocytes per Microcarrier in Spheroid Culture using Cytodex 3 Microcarrier. , 2007 .

[25]  W. Tan,et al.  [Optimization of attachment conditions for rabbit mesenchymal stem cells in cytodex 3 microcarrier culture systems]. , 2007, Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.

[26]  H. Sakurai,et al.  Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin αv‐mediated ADAM activity in hepatocellular carcinoma: A novel functional target for gefitinib , 2006, Cancer science.

[27]  Maddalena Illario,et al.  Fibronectin-Induced Proliferation in Thyroid Cells Is Mediated by αvβ3 Integrin through Ras/Raf-1/MEK/ERK and Calcium/CaMKII Signals , 2005 .

[28]  J. Gutiérrez,et al.  Assessment of the viral safety of antivenoms fractionated from equine plasma , 2004, Biologicals.

[29]  Y. Sugiyama,et al.  Immunolocalization of extracellular matrix components and integrins during mouse liver development , 2004, Hepatology.

[30]  Yoshinori Kawase,et al.  Power consumption and solid suspension performance of large-scale impellers in gas–liquid–solid three-phase stirred tank reactors , 2004 .

[31]  X. Tao,et al.  Preparation and culture of hepatocyte on gelatin microcarriers. , 2003, Journal of biomedical materials research. Part A.

[32]  Jaromir Ruzicka,et al.  Real-time determination of glucose consumption by live cells using a lab-on-valve system with an integrated microbioreactor. , 2002, The Analyst.

[33]  Ke Chen,et al.  Primary porcine hepatocytes with portal vein serum cultured on microcarriers or in spheroidal aggregates. , 2000, World journal of gastroenterology.

[34]  J. Lehmann,et al.  Cultivation of immortalized human hepatocytes HepZ on macroporous CultiSpher G microcarriers. , 2000, Biotechnology and bioengineering.

[35]  G. Michalopoulos,et al.  Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor‐α in adult rat liver , 1994, Hepatology.

[36]  S. Levenson,et al.  Transplantation of microcarrier‐attached hepatocytes into 90% partially hepatectomized rats , 1988, Hepatology.

[37]  J. Hamel,et al.  Hydrodynamic effects on animal cells grown in microcarrier cultures , 1987, Biotechnology and bioengineering.

[38]  R. Dourmashkin,et al.  Molecular requirements for adhesion and spreading of hamster fibroblasts. , 1979, Experimental cell research.

[39]  F. Grinnell,et al.  Cell adhesion and spreading factor. Partial purification and properties. , 1977, Experimental cell research.

[40]  L. Friedman,et al.  Assessment of liver function and diagnostic studies , 2018 .

[41]  N. Sussman,et al.  Artificial liver. , 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[42]  J. Wendon,et al.  Acute liver failure. , 2013, The New England journal of medicine.

[43]  G. Blüml Microcarrier Cell Culture Technology , 2007 .

[44]  K. Böker,et al.  Akutes Leberversagen , 2001, Der Internist.

[45]  Y. Kamohara,et al.  Artificial liver. , 1999, Transplantation Proceedings.

[46]  A. Bakker,et al.  Suspension of solid particles with gassed impellers , 1990 .

[47]  D. I. Wang,et al.  Hydrodynamic effects on animal cells grown in microcarrier cultures , 2022 .