Current research activity in biosensors

Biosensors consist of a molecular recognition element and a transducer. Since the first biosensor was developed by Updike and Hicks [1] many biosensors and their associated techniques have been studied and developed. In this review current research activity on the fundamentals and applications of biosensors is summarized. In discussion of the former, molecular recognition elements, techniques and tools for biosensor construction, and basic biosensor devices are introduced. Coverage of the latter includes description of biosensors for environmental, food, and clinical fields. Chemical sensors developed in our laboratory for environmental monitoring are also described. This review mainly summarizes work performed by our group and by our colleagues, and refers to the main review articles summarizing each field of biosensor research in recent years.

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[64]  I. Karube,et al.  Simple and rapid detection method using surface plasmon resonance for dioxins, polychlorinated biphenylx and atrazine , 2001 .

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[66]  Phosphate Sensor Composed from Immobilized Pyruvate Oxidase and an Oxygen Electrode , 1991 .

[67]  S. Howorka,et al.  Sequence-specific detection of individual DNA strands using engineered nanopores , 2001, Nature Biotechnology.

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[70]  Isao Karube,et al.  An integrated module for sensing pO2, pCO2, and pH , 2000 .

[71]  I Karube,et al.  Detection of PCR products of Escherichia coli O157:H7 in human stool samples using surface plasmon resonance (SPR). , 2000, FEMS immunology and medical microbiology.

[72]  Va,et al.  Recent patents in biosensor technology , 2002, Nature Biotechnology.

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[76]  Determination of cyanide using a microbial sensor , 1996, Applied biochemistry and biotechnology.

[77]  E. V. Piletskaya,et al.  Towards the D1 Protein Application for the Development of Sensors Specific for Herbicides , 1998 .

[78]  I. Karube,et al.  Application of Linear Image Sensor Toi Immunoassay Based Oin Turbidimetry of Antibody-Bound Latex Beads , 1987 .

[79]  Y. Nakashima,et al.  SPR immunosensor integrated two miniature enzyme sensors , 1999 .

[80]  I. Karube,et al.  A compact optical system for multi‐determination of biochemical oxygen demand using disposable strips , 2001 .

[81]  K. Sode,et al.  The production of soluble pyrroloquinoline quinone glucose dehydrogenase by Klebsiella pneumoniae, the alternative host of PQQ enzymes , 2000, Biotechnology Letters.

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[86]  I. Karube,et al.  Monitoring of the composting process using a mediator-type biochemical oxygen demand sensor , 2001 .

[87]  I. Karube,et al.  Evaluation of chemical oxygen demand (COD) based on coulometric determination of electrochemical oxygen demand (EOD) using a surface oxidized copper electrode , 1999 .

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[92]  K Mosbach,et al.  Some new developments and challenges in non‐covalent molecular imprinting technology , 1998, Journal of molecular recognition : JMR.

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[99]  I Karube,et al.  Application of a linear alkylbenzene sulfonate biosensor to river water monitoring. , 1998, Biosensors & bioelectronics.

[100]  Masayasu Suzuki,et al.  Chemical cross-talk in flow-type integrated enzyme sensors , 2000 .

[101]  S O Engblom,et al.  The phosphate sensor. , 1998, Biosensors & bioelectronics.

[102]  K. Killham,et al.  Design and Application of a Biosensor for Monitoring Toxicity of Compounds to Eukaryotes , 2000, Applied and Environmental Microbiology.

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[105]  I. Karube,et al.  Copper proteins immobilised on gold electrodes for (bio)analytical studies. , 2002, Biosensors & bioelectronics.

[106]  George G. Guilbault,et al.  Development of a quartz crystal microbalance (QCM) immunosensor for the detection of Listeria monocytogenes , 2001 .

[107]  I Karube,et al.  Improvement of a mediator-type biochemical oxygen demand sensor for on-site measurement. , 2001, Journal of biotechnology.

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[109]  D G Myszka,et al.  Survey of the 1998 optical biosensor literature , 1999, Journal of molecular recognition : JMR.

[110]  I Karube,et al.  Application of peptide nucleic acid to the direct detection of deoxyribonucleic acid amplified by polymerase chain reaction. , 1999, Biosensors & bioelectronics.

[111]  Toshifumi Takeuchi,et al.  Combinatorial Molecular Imprinting: An Approach to Synthetic Polymer Receptors , 1999 .

[112]  S. Cosnier,et al.  Electrogenerated Poly(Chiral Dicarbazole) Films for the Reagentless Grafting of Enzymes , 2000 .

[113]  I Karube,et al.  Dioxin detection based on immunoassay using a polyclonal antibody against octa-chlorinated dibenzo-p-dioxin (OCDD). , 2001, The Analyst.

[114]  J. Anzai,et al.  Layer-by-layer construction of enzyme multilayers on an electrode for the preparation of glucose and lactate sensors: elimination of ascorbate interference by means of an ascorbate oxidase multilayer. , 1998, Analytical chemistry.

[115]  I. Karube,et al.  Relationship between theoretical oxygen demand and photocatalytic chemical oxygen demand for specific classes of organic chemicals , 2000 .

[116]  S. Cosnier,et al.  Electrogeneration of a Hydrophilic Cross‐Linked Polypyrrole Film for Enzyme Electrode Fabrication. Application to the Amperometric Detection of Glucose , 2001 .

[117]  I. Karube,et al.  Application of polymer-embedded proteins to fabrication of DNA array. , 2000, Biotechnology and bioengineering.

[118]  S Zhang,et al.  Materials and techniques for electrochemical biosensor design and construction. , 2000, Biosensors & bioelectronics.

[119]  K. Mosbach,et al.  Molecularly imprinted polymers and their use in biomimetic sensors. , 2000, Chemical reviews.

[120]  Z. Qian,et al.  BOD measurement in the presence of heavy metal ions using a thermally-killed-Bacillus subtilis biosensor , 1999 .

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[122]  A. Turner,et al.  Capillary electrophoresis coupled to biosensor detection. , 2000, Journal of chromatography. A.

[123]  I. Karube,et al.  Disposable sensor for biochemical oxygen demand , 1996, Applied Microbiology and Biotechnology.

[124]  T. Matsunaga,et al.  DNA extraction using modified bacterial magnetic particles in the presence of amino silane compound. , 2002, Journal of biotechnology.

[125]  G. Whitesides,et al.  Patterning proteins and cells using soft lithography. , 1999, Biomaterials.

[126]  M. Okada,et al.  The extremely rapid oligonucleotide hybridization and high throughput detection of microbial gene sequences using fluorescence polarization. , 2001, Biosensors & bioelectronics.

[127]  I Karube,et al.  Detection of atrazine based on the SPR determination of P450 mRNA levels in Saccharomyces cerevisiae. , 2000, Analytical chemistry.

[128]  Jean-Louis Marty,et al.  Disposable cholinesterase biosensor for the detection of pesticides in water-miscible organic solvents , 2001 .

[129]  Isao Karube,et al.  A flow method with photocatalytic oxidation of dissolved organic matter using a solid-phase (TiO2) reactor followed by amperometric detection of consumed oxygen. , 2002, Analytical chemistry.

[130]  E Tamiya,et al.  A compactly integrated flow cell with a chemiluminescent FIA system for determining lactate concentration in serum. , 2001, Analytical chemistry.

[131]  Sergey A. Piletsky,et al.  Application of natural receptors in sensors and assays. , 2002, Analytical chemistry.

[132]  G. Guilbault,et al.  An immunosensor based on the glucose oxidase label and optical oxygen detection. , 1999, Analytical chemistry.

[133]  I. Karube,et al.  A fluorescence polarization assay using oligonucleotide probes for the rapid detection of verotoxin-producing Escherichia coli. , 2000, Journal of biotechnology.

[134]  R. Breaker,et al.  Immobilized RNA switches for the analysis of complex chemical and biological mixtures , 2001, Nature Biotechnology.

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[138]  I. Karube,et al.  A simple nitrate sensor system using titanium trichloride and an ammonium electrode , 2002 .

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[145]  I. Karube,et al.  Chemical oxygen demand sensor employing a thin layer electrochemical cell , 1999 .

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[149]  I Karube,et al.  A novel method of immobilizing antibodies on a quartz crystal microbalance using plasma-polymerized films for immunosensors. , 1996, Analytical chemistry.

[150]  I. Karube,et al.  Determination of Damaged Starch and Diastatic Activity in Wheat Flour Using a Flow-Injection Analysis Biosensor Method , 1997 .

[151]  J. Marty,et al.  Improved multianalyte detection of organophosphates and carbamates with disposable multielectrode biosensors using recombinant mutants of Drosophila acetylcholinesterase and artificial neural networks. , 2000, Biosensors & bioelectronics.

[152]  Christophe A. Marquette,et al.  Semi-automated membrane based chemiluminescent immunosensor for flow injection analysis of okadaic acid in mussels , 1999 .

[153]  I Karube,et al.  Micromachined severinghaus-type carbon dioxide electrode. , 1999, Analytical chemistry.

[154]  I. Karube,et al.  Flow injection spectrophotometric determination of sulfated bile acids in urine with immobilized enzyme reactors using water soluble tetrazolium blue-5 , 2001 .

[155]  I Karube,et al.  A mediator-type biosensor as a new approach to biochemical oxygen demand estimation. , 2000, The Analyst.

[156]  I Karube,et al.  Optical fiber biosensor for the determination of low biochemical oxygen demand. , 2000, Biosensors & bioelectronics.

[157]  I. Karube,et al.  Interaction of three-way DNA junctions with steroids. , 2000, Nucleic acids research.

[158]  T. Takeuchi,et al.  Surface plasmon resonance sensor using molecularly imprinted polymer for detection of sialic acid. , 2001, Biosensors & bioelectronics.

[159]  I Karube,et al.  Thin-film glucose biosensor based on plasma-polymerized film: simple design for mass production. , 2000, Analytical chemistry.

[160]  R. Rich,et al.  Survey of the 1999 surface plasmon resonance biosensor literature , 2000, Journal of molecular recognition : JMR.

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[163]  M. Kawasaki,et al.  Chemiluminescence enzyme immunoassay using bacterial magnetic particles. , 1996, Analytical chemistry.

[164]  I. Karube,et al.  Selective piezoelectric odor sensors using molecularly imprinted polymers , 1999 .

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[167]  I Karube,et al.  A chemiluminescent FIA biosensor for phosphate ion monitoring using pyruvate oxidase. , 1997, Biosensors & bioelectronics.

[168]  A. El'skaya,et al.  Fluorescence detection of β-estradiol using a molecularly imprinted polymer , 2000 .

[169]  L. Ye,et al.  Polymers recognizing biomolecules based on a combination of molecular imprinting and proximity scintillation: a new sensor concept. , 2001, Journal of the American Chemical Society.

[170]  N J Goddard,et al.  Development of a green fluorescent protein reporter for a yeast genotoxicity biosensor. , 1998, Biosensors & bioelectronics.

[171]  Development of a biosensor for gaseous cyanide in solution , 1996 .

[172]  I Karube,et al.  Detection of PCR products in solution using surface plasmon resonance. , 1999, Analytical chemistry.

[173]  E. Tamiya,et al.  Enzyme immunoassay by capillary electrophoresis with laser induced fluorescence detection , 1999 .

[174]  Shuji Aso,et al.  Miniature surface-plasmon resonance immunosensors – rapid and repetitive procedure , 2002, Analytical and bioanalytical chemistry.

[175]  Isao Karube,et al.  Application of chimeric RNA–DNA oligonucleotides to the detection of pathogenic microorganisms using surface plasmon resonance , 2000 .

[176]  I Karube,et al.  Refractive-index and thickness sensitivity in surface plasmon resonance spectroscopy. , 1999, Applied optics.

[177]  Jean Louis Marty,et al.  Acetylcholine enzyme sensor for determining methamidophos insecticide: Evaluation of some genetically modified acetylcholinesterases from Drosophila melanogaster , 2001 .

[178]  I. Karube,et al.  Pulse immunoassay for human immunoglobulin G using antibody bound latex beads. , 1987, Biosensors.

[179]  I. Karube,et al.  Novel surface plasmon resonance sensor chip functionalized with organic silica compounds for antibody attachment , 1998 .

[180]  J. Haginaka,et al.  Separation and sensing based on molecular recognition using molecularly imprinted polymers. , 1999, Journal of chromatography. B, Biomedical sciences and applications.

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[186]  K. A. Friedman,et al.  In situ assembled mass-transport controlling micromembranes and their application in implanted amperometric glucose sensors. , 2000, Analytical chemistry.

[187]  T. Bachmann,et al.  A disposable acetylcholinesterase-based electrode biosensor to detect anatoxin-a(s) in water , 2002, Analytical and bioanalytical chemistry.

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[189]  Isao Karube,et al.  Flow injection microbial trichloroethylene sensor. , 2002, Talanta.

[190]  Kenji Yokoyama,et al.  Design of peptide that recognizes double-stranded DNA. , 2003, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[191]  T. Matsunaga,et al.  Chemiluminescence enzyme immunoassay using ProteinA-bacterial magnetite complex , 1999 .

[192]  I. Karube,et al.  Cloning and expression of a gene encoding cyanidase from Pseudomonas stutzeri AK61 , 1998, Applied Microbiology and Biotechnology.

[193]  Y. Murakami,et al.  Characterization of native glutamate dehydrogenase from an aerobic hyperthermophilic archaeon Aeropyrum pernix K1 , 2001, Applied Microbiology and Biotechnology.

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[195]  I. Karube,et al.  Detection of the red tide-causing plankton Chattonella marina using a piezoelectric immunosensor , 1996 .

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[198]  K. Killham,et al.  Biosensing the acute toxicity of metal interactions: Are they additive, synergistic, or antagonistic? , 2000 .

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[200]  I. Karube,et al.  Highly sensitive chemiluminescence flow-injection detection of the red tide phytoplankton Heterosigma carterae , 1999 .

[201]  I. Karube,et al.  A glucose sensor with a plasma-polymerized thin film fabricated by dry processes , 1999 .

[202]  Isao Karube,et al.  Development of highly sensitive BOD sensor and its evaluation using preozonation , 1999 .

[203]  C. Watson,et al.  DNA chip technolgy , 1999 .

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[205]  I. Karube,et al.  Amplification immunoassay for the determination of Hepatitis B surface antigen , 1991, Applied biochemistry and biotechnology.

[206]  I Karube,et al.  Micromachining Technology and Biosensors , 1995, Annals of the New York Academy of Sciences.

[207]  A novel microbial sensor for the determination of cyanide , 1995 .

[208]  L. Heinemann,et al.  Sensors for glucose monitoring: technical and clinical aspects , 2001, Diabetes/metabolism research and reviews.

[209]  I. Karube,et al.  Plasma Polymerized Films for Sensor Devices , 2000 .

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