Multi-Step FRET-Based Long-Range

Nanoscale communication based on Forster Reso- nance Energy Transfer (FRET) is a promising paradigm that allows future molecular-size machines to communicate with each other over distances up to 10 nm using the excited state energies of fluorescent molecules. In this study, we propose a novel nanoscale communication method based on multi-step FRET us- ing identical fluorophores as relay nodes between communicating nanomachines, and utilizing multi-exciton transmission scheme in order to improve the limited range of the communication and achievable transmission rate over the nanoscale channel. We in- vestigate two communication scenarios: immobile nanomachines communicating through a channel in a host material with linearly located relay nodes, and mobile nanomachines communicating through a channel in a 3-dimensional aqueous environment with randomly deployed relay nodes. We simulate the communication over these channels with realistic algorithms considering the high degree of randomness intrinsic to FRET phenomenon. Using the simulation results and following a Monte Carlo approach, we evaluate the performance of the channels by means of information theoretical capacity and interference probability. We show that multi-step FRET-based communication significantly outperforms the other biologically inspired nanocommunication techniques proposed so far in terms of maximum achievable data transmission rates. The results underline the compatibility and practicality of the FRET-based communication for several applications ranging from molecular computers to nanosensor networks.