Enhancement of antimicrobial activity by synthetic ion channel synergy.

Hydraphile synthetic ion channels were found to enhance the cytotoxicity to E. coli and B. subtilis of erythromycin, kanamycin, rifampicin, and tetracycline when co-administered with the antibiotic at sublethal concentrations of channel.

[1]  Christopher T. Walsh,et al.  Antibiotics for Emerging Pathogens , 2009, Science.

[2]  G. Wong,et al.  Cationic amphiphiles increase activity of aminoglycoside antibiotic tobramycin in the presence of airway polyelectrolytes. , 2009, Journal of the American Chemical Society.

[3]  Gregory N Tew,et al.  De novo designed synthetic mimics of antimicrobial peptides. , 2008, Current opinion in biotechnology.

[4]  G. Gokel,et al.  Synthetic, Biologically Active Amphiphilic Peptides , 2007, Chemistry & biodiversity.

[5]  N. Voyer,et al.  Synthesis, characterization and cytolytic activity of alpha-helical amphiphilic peptide nanostructures containing crown ethers. , 2007, Organic & biomolecular chemistry.

[6]  Y. Shai,et al.  Ultrashort antibacterial and antifungal lipopeptides , 2006, Proceedings of the National Academy of Sciences.

[7]  W. M. Leevy,et al.  NMR and ion selective electrode studies of hydraphile channels correlate with biological activity in E. coli and B. subtilis. , 2005, Chemical communications.

[8]  Vladimir Torchilin,et al.  Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells. , 2005, Organic & biomolecular chemistry.

[9]  W. M. Leevy,et al.  Correlation of bilayer membrane cation transport and biological activity in alkyl-substituted lariat ethers. , 2005, Organic & biomolecular chemistry.

[10]  George W Gokel,et al.  Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths. , 2005, Journal of the American Chemical Society.

[11]  W. M. Leevy,et al.  Synthetic hydraphile channels of appropriate length kill Escherichia coli. , 2002, Journal of the American Chemical Society.

[12]  M. Zasloff Antimicrobial peptides of multicellular organisms , 2002, Nature.

[13]  Glenn E. M. Maguire,et al.  Hydraphile Channels: Structural and Fluorescent Probes of Position and Function in a Phospholipid Bilayer , 1999 .

[14]  G. Gokel,et al.  Spacer chain length dependence in hydraphile channels , 2001 .

[15]  George W. Gokel,et al.  Hydraphiles: design, synthesis and analysis of a family of synthetic, cation-conducting channels , 2000 .

[16]  George W. Gokel,et al.  Cation flux dependence on carbon chain length in hydraphile channels as assessed by dynamic 23Na NMR methods in phospholipid bilayers , 1998 .