Development of Animal Models to Test the Fundamental Basis of Gene–Environment Interactions

[1]  L. Koch,et al.  Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance. , 2007, American journal of physiology. Endocrinology and metabolism.

[2]  Godfrey L. Smith,et al.  Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity , 2007, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[3]  Godfrey L. Smith,et al.  Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. , 2007 .

[4]  R. A. Howlett,et al.  Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. , 2006, Journal of applied physiology.

[5]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.

[6]  Oksana Gavrilova,et al.  p53 Regulates Mitochondrial Respiration , 2006, Science.

[7]  Brian O'Rourke,et al.  The mitochondrial origin of postischemic arrhythmias. , 2005, The Journal of clinical investigation.

[8]  John D. Storey,et al.  A network-based analysis of systemic inflammation in humans , 2005, Nature.

[9]  M. Clark,et al.  Interindividual Variation in Posture Allocation: Possible Role in Human Obesity , 2005, Science.

[10]  Ø. Ellingsen,et al.  Cardiovascular Risk Factors Emerge After Artificial Selection for Low Aerobic Capacity , 2005, Science.

[11]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[12]  R. A. Howlett,et al.  Selected contribution: skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance. , 2003, Journal of applied physiology.

[13]  P. Puigserver,et al.  Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. , 2003, Endocrine reviews.

[14]  R. Collins,et al.  Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies , 2002, The Lancet.

[15]  L. Koch,et al.  Determinants of maximal O(2) uptake in rats selectively bred for endurance running capacity. , 2002, Journal of applied physiology.

[16]  Victor F. Froelicher,et al.  Exercise capacity and mortality among men referred for exercise testing. , 2002, The New England journal of medicine.

[17]  Jonathan Flint,et al.  Finding the molecular basis of quatitative traits: successes and pitfalls , 2001, Nature Reviews Genetics.

[18]  C. Bouchard,et al.  Individual differences in response to regular physical activity. , 2001, Medicine and science in sports and exercise.

[19]  Claude Bouchard,et al.  DOSE-RESPONSE ISSUES CONCERNING PHYSICAL ACTIVITY & HEALTH: A SUMMARY , 2001 .

[20]  L. Koch,et al.  Artificial selection for intrinsic aerobic endurance running capacity in rats. , 2001, Physiological genomics.

[21]  J. Nadeau.  Muta-genetics or muta-genomics: the feasibility of large-scale mutagenesis and phenotyping programs , 2000, Mammalian Genome.

[22]  A M Zeiher,et al.  Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. , 2000, Circulation.

[23]  C. Bouchard,et al.  Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study. , 2000, Journal of applied physiology.

[24]  C. Hansen,et al.  Development of the National Institutes of Health genetically heterogeneous rat stock. , 1984, Alcoholism, clinical and experimental research.

[25]  M. Kimura,et al.  On the maximum avoidance of inbreeding , 1963 .

[26]  G. Schuler,et al.  Exercise Capacity in Patients With Chronic Heart Failure Regular Physical Exercise Corrects Endothelial Dysfunction and Improves , 1998 .