Applications of soft-switching full-bridge converter and rotational electric field to transdermal drug delivery

This paper presents applications of a soft-switching full-bridge converter to generate pulsed voltage (PV) for exciting tissue, which includes transdermal drug delivery (TDD), transcutaneous electrical nerve stimulation, functional electrical stimulation, etc. Particularly, in TDD it offers many potential advantages over conventional methods, such as oral and injection, and it avoids drug degradation through gastro-intestinal and liver. To design a portable driving system with battery source, the proposed converter is equipped with a soft-switching cell to achieve zero voltage switching or zero current switching, improving efficiency about 20%. The overall system needs only a set of soft-switching cell to achieve soft-switching feature even though there are N sets of PVs, reducing size and cost significantly. Moreover, a rotational electrical field concept is introduced to further improve effectiveness of drug delivery. Experimental results of a 150 V output voltage and 18 W peak power have demonstrated the feasibility of the proposed converter.

[1]  Brian W. Barry,et al.  Dermatological Formulations: Percutaneous Absorption , 1983 .

[2]  Fred C. Lee,et al.  A soft-switched, full-bridge boost converter employing an active-clamp circuit , 1996, PESC Record. 27th Annual IEEE Power Electronics Specialists Conference.

[3]  Adrian C. Williams,et al.  Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement , 2004, Pharmaceutical Research.

[4]  Adrian C. Williams,et al.  Characterization of complex coacervates of some tricyclic antidepressants and evaluation of their potential for enhancing transdermal flux , 1996 .

[5]  M. Roberts,et al.  Ion‐pair Formation as a Strategy to Enhance Topical Delivery of Salicylic Acid , 2000, The Journal of pharmacy and pharmacology.

[6]  Weaver,et al.  Theory of electrical creation of aqueous pathways across skin transport barriers. , 1999, Advanced drug delivery reviews.

[7]  Russell O. Potts,et al.  Effect of current, ionic strength and temperature on the electrical properties of skin , 1993 .

[8]  B. W. Barry,et al.  Mechanistic study into the enhanced transdermal permeation of a model beta-blocker, propranolol, by fatty acids: a melting point depression effect. , 2001, International journal of pharmaceutics.

[9]  M. Allen,et al.  Microfabricated microneedles for gene and drug delivery. , 2000, Annual review of biomedical engineering.

[10]  G. Cevc,et al.  Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. , 1992, Biochimica et biophysica acta.

[11]  B. W. Barry,et al.  Novel mechanisms and devices to enable successful transdermal drug delivery. , 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[12]  F. Lee,et al.  Zero voltage and zero current switching full bridge PWM converter using secondary active clamp , 1996, PESC Record. 27th Annual IEEE Power Electronics Specialists Conference.

[13]  J. Friedland,et al.  Skin care and the topical treatment of aging skin. , 2000, Clinics in plastic surgery.

[14]  Murthy Sn,et al.  Magnetophoresis: an approach to enhance transdermal drug diffusion. , 1999 .

[15]  C. E. Burton,et al.  The application of Bode analysis to skin impedance. , 1974, Psychophysiology.

[16]  James C. Weaver,et al.  Electroporation of cells and tissues , 2000 .

[17]  Howard I. Maibach,et al.  Iontophoresis: an alternative to the use of carriers in cutaneous drug delivery , 1996 .

[18]  V. Meleshin,et al.  Full-bridge isolated current fed converter with active clamp , 1999, APEC '99. Fourteenth Annual Applied Power Electronics Conference and Exposition. 1999 Conference Proceedings (Cat. No.99CH36285).

[19]  M. Prausnitz,et al.  A practical assessment of transdermal drug delivery by skin electroporation. , 1999, Advanced drug delivery reviews.

[20]  T. Higuchi,et al.  Enhancement of percutaneous absorption by the use of volatile: nonvolatile systems as vehicles. , 1969, Journal of Pharmacy and Science.

[21]  G. Cevc.  Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery. , 1996, Critical reviews in therapeutic drug carrier systems.

[22]  Lykken Dt,et al.  Properties of electrodes used in electrodermal measurement. , 1959 .

[23]  I. Barbi,et al.  A new ZVS-PWM active-clamping high power factor rectifier: analysis, design, and experimentation , 1998, APEC '98 Thirteenth Annual Applied Power Electronics Conference and Exposition.

[24]  N. Kollias,et al.  Topical Drug Delivery in Humans with a Single Photomechanical Wave , 1999, Pharmaceutical Research.

[25]  J. A. Gimm,et al.  Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures. , 1996, Journal of pharmaceutical sciences.

[26]  D. Lykken.  Properties of electrodes used in electrodermal measurement. , 1959, Journal of comparative and physiological psychology.

[27]  J. Hadgraft,et al.  The dermal delivery of lignocaine: influence of ion pairing. , 2000, International journal of pharmaceutics.

[28]  A. van Boxtel,et al.  Skin resistance during square-wave electrical pulses of 1 to 10 mA , 1977, Medical and Biological Engineering and Computing.

[29]  J. Denuzzio,et al.  Electrochemical and iontophoretic studies of human skin , 1990 .

[30]  P. Venables,et al.  Direct measurement of skin conductance: a proposal for standardization. , 1971, Psychophysiology.

[31]  Y. Kalia,et al.  Transdermal drug delivery: overcoming the skin's barrier function. , 2000, Pharmaceutical science & technology today.

[32]  G. Cevc,et al.  Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier, and prolongation of local pain insensitivity by anesthetic liposomes. , 1992, Anesthesia and analgesia.

[33]  Mark R. Prausnitz,et al.  The effects of electric current applied to skin: A review for transdermal drug delivery , 1996 .

[34]  H. Schwan,et al.  Electrical Impedance of the Human Body , 1968 .