Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation
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Victor Pham | Dongjun Fu | Xuesen Li | E. Uchio | X. Zi | B. Hoang | Liankun Song | Matthew Tippin | Raymond Rendon
[1] M. Loda,et al. Compound Genomic Alterations of TP53, PTEN, and RB1 Tumor Suppressors in Localized and Metastatic Prostate Cancer. , 2019, European urology.
[2] R. Bjerkvig,et al. Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy , 2018, Autophagy.
[3] Colm J. Ryan,et al. Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer , 2018, Oncogene.
[4] Ling Zhang,et al. Overactivated neddylation pathway in human hepatocellular carcinoma , 2018, Cancer medicine.
[5] D. Faller,et al. Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML. , 2018, Blood.
[6] Mallikarjuna Korivi,et al. Chalcone flavokawain B induces autophagic-cell death via reactive oxygen species-mediated signaling pathways in human gastric carcinoma and suppresses tumor growth in nude mice , 2017, Archives of Toxicology.
[7] H. He,et al. Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein. , 2016, Cell reports.
[8] M van Duin,et al. Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma , 2016, Leukemia.
[9] G. Mulligan,et al. A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma , 2016, Investigational New Drugs.
[10] G. Mulligan,et al. Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma , 2015, Clinical Cancer Research.
[11] Jeffrey W. Clark,et al. Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors , 2015, Clinical Cancer Research.
[12] F. Zhan,et al. NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma , 2015, Clinical Cancer Research.
[13] M. Maris,et al. Pevonedistat (MLN4924), a First‐in‐Class NEDD8‐activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study , 2015, British journal of haematology.
[14] A. Omar,et al. In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice , 2015, Drug design, development and therapy.
[15] M. Peter,et al. Protein neddylation: beyond cullin–RING ligases , 2014, Nature Reviews Molecular Cell Biology.
[16] P. Nordlund,et al. The cellular thermal shift assay for evaluating drug target interactions in cells , 2014, Nature Protocols.
[17] Q. Gao,et al. Overactivated neddylation pathway as a therapeutic target in lung cancer. , 2014, Journal of the National Cancer Institute.
[18] Wennuan Liu,et al. Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma , 2013, Clinical Cancer Research.
[19] X. Zi,et al. Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis , 2013, Molecular Cancer.
[20] M. Rubin,et al. Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity. , 2013, European urology.
[21] M. Lilly,et al. Kava Components Down-Regulate Expression of AR and AR Splice Variants and Reduce Growth in Patient-Derived Prostate Cancer Xenografts in Mice , 2012, PloS one.
[22] K. Knudsen,et al. Time to stratify? The retinoblastoma protein in castrate-resistant prostate cancer , 2011, Nature Reviews Urology.
[23] P. Nelson,et al. The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression. , 2010, The Journal of clinical investigation.
[24] Zhongbo Liu,et al. Flavokawain B, a kava chalcone, induces apoptosis via up‐regulation of death‐receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth , 2010, International journal of cancer.
[25] P. Chueh,et al. Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. , 2010, Free radical biology & medicine.
[26] W. Dubiel. Resolving the CSN and CAND1 paradoxes. , 2009, Molecular cell.
[27] R. Osman,et al. Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail , 2008, Proceedings of the National Academy of Sciences.
[28] C. Hawkey,et al. Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells--evidence for cullin dimerization. , 2007, Cellular signalling.
[29] A. Stoffel,et al. Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas. , 2006, Cancer research.
[30] X. Zi,et al. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. , 2005, Cancer research.
[31] W. Krek,et al. The F‐box protein Skp2 is a ubiquitylation target of a Cul1‐based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts , 2000, The EMBO journal.
[32] Y. Xiong,et al. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[33] Joseph Locker,et al. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice , 2010, Nature Genetics.