Glucocorticoids and natural killer cells: A suppressive relationship.

[1]  A. La Cava,et al.  Editorial: The Role of Natural Killer Cells in Autoimmune Diseases , 2021, Frontiers in Immunology.

[2]  Joao C. Guimaraes,et al.  Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy , 2021, Nature.

[3]  M. Caligiuri,et al.  Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia , 2021, Blood.

[4]  A. Grauer,et al.  Adrenal tumors provide insight into the role of cortisol in NK cell activity. , 2021, Endocrine-related cancer.

[5]  N. Tarantino,et al.  Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus , 2021, Frontiers in Immunology.

[6]  S. Mustjoki,et al.  Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells. , 2021, Blood advances.

[7]  Y. Kerdiles,et al.  Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop , 2021, Science.

[8]  S. Sarin,et al.  Differential blood transcriptome modules predict response to corticosteroid therapy in alcoholic hepatitis , 2021, JHEP reports : innovation in hepatology.

[9]  C. Hammer,et al.  Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion , 2021, Nature Reviews Cancer.

[10]  E. Gianchecchi,et al.  Natural Killer Cells: Potential Biomarkers and Therapeutic Target in Autoimmune Diseases? , 2021, Frontiers in Immunology.

[11]  Federico Vázquez,et al.  NK Cell Subsets Changes in Partial Remission and Early Stages of Pediatric Type 1 Diabetes , 2021, Frontiers in Immunology.

[12]  B. Becher,et al.  Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes , 2021, Nature.

[13]  K. Ikuta,et al.  Control of immunity by glucocorticoids in health and disease , 2020, Seminars in Immunopathology.

[14]  N. Tumino,et al.  The Immune Checkpoint PD-1 in Natural Killer Cells: Expression, Function and Targeting in Tumour Immunotherapy , 2020, Cancers.

[15]  Jeffrey S. Miller,et al.  Exploring the NK cell platform for cancer immunotherapy , 2020, Nature Reviews Clinical Oncology.

[16]  R. Ramaswami,et al.  Anti-PD-1 and Anti-PD-L1 Monoclonal Antibodies in People Living with HIV and Cancer , 2020, Current HIV/AIDS Reports.

[17]  P. Myles,et al.  Data on the modulatory effects of a single bolus dexamethasone on the surface marker expression of various leucocyte subsets , 2020, Data in brief.

[18]  C. Watzl,et al.  Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine , 2020, Cellular & Molecular Immunology.

[19]  N. Tumino,et al.  Glucocorticoids and the cytokines IL-12, IL-15 and IL-18 present in the tumor microenvironment induce PD-1 expression on human Natural Killer cells. , 2020, The Journal of allergy and clinical immunology.

[20]  Michael M. Henry,et al.  Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis. , 2020, The New England journal of medicine.

[21]  Zilong Lu,et al.  The clinical course and its correlated immune status in COVID-19 pneumonia , 2020, Journal of Clinical Virology.

[22]  A. Levin,et al.  Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis. , 2020, The New England journal of medicine.

[23]  P. Thall,et al.  Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors. , 2020, The New England journal of medicine.

[24]  C. Riccardi,et al.  Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes , 2020, Journal of translational autoimmunity.

[25]  D. Campana,et al.  NK cells for cancer immunotherapy , 2020, Nature Reviews Drug Discovery.

[26]  I. Bruce,et al.  Trial of Anifrolumab in Active Systemic Lupus Erythematosus. , 2019, The New England journal of medicine.

[27]  Konstantin Yakimchuk,et al.  Mathematical modeling of immune modulation by glucocorticoids , 2019, Biosyst..

[28]  A. Tommasini,et al.  Familial hypogammaglobulinemia with high RTE and naïve T lymphocytes , 2019, Inflammation Research.

[29]  A. Boots,et al.  Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica , 2019, Front. Immunol..

[30]  C. Riccardi,et al.  Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation , 2019, Front. Immunol..

[31]  D. Jackson,et al.  Stress-elicited glucocorticoid receptor signaling upregulates TIGIT in innate-like invariant T lymphocytes , 2019, Brain, Behavior, and Immunity.

[32]  L. Boon,et al.  Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment , 2019, Oncoimmunology.

[33]  S. Hodge,et al.  Therapeutic Targeting Steroid Resistant Pro-Inflammatory NK and NKT-Like Cells in Chronic Inflammatory Lung Disease , 2019, International journal of molecular sciences.

[34]  Li Chen,et al.  Depression Promotes Hepatocellular Carcinoma Progression through a Glucocorticoids Mediated Up-Regulation of PD-1 Expression in Tumor infiltrating NK Cells. , 2019, Carcinogenesis.

[35]  A. Thomsen.  Commentary: Endogenous glucocorticoids control host resistance to viral infection through tissue-specific regulation of PD-1 expression on NK cells , 2018, Cellular & Molecular Immunology.

[36]  R. Vance,et al.  Tumor‐Derived cGAMP Triggers a STING‐Mediated Interferon Response in Non‐tumor Cells to Activate the NK Cell Response , 2018, Immunity.

[37]  C. Biron.  Glucocorticoids and NK cell PD-1 , 2018, Nature Immunology.

[38]  É. Vivier,et al.  Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells , 2018, Nature Immunology.

[39]  C. Riccardi,et al.  A dual role for glucocorticoid-induced leucine zipper in glucocorticoid function: tumor growth promotion or suppression? , 2018, Cell Death & Disease.

[40]  M. Cabana,et al.  Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations , 2018, The New England journal of medicine.

[41]  J. Orange,et al.  Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity , 2018, Leukemia.

[42]  N. Glaichenhaus,et al.  Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells , 2017, The Journal of experimental medicine.

[43]  B. Blazar,et al.  Acute Graft-versus-Host Disease - Biologic Process, Prevention, and Therapy. , 2017, The New England journal of medicine.

[44]  K. Yakimchuk,et al.  Regulatory effects of dexamethasone on NK and T cell immunity , 2017, Inflammopharmacology.

[45]  C. Riccardi,et al.  SUMO proteins: Guardians of immune system. , 2017, Journal of autoimmunity.

[46]  R. Grassi‐Oliveira,et al.  Evidence for Immune Activation and Resistance to Glucocorticoids Following Childhood Maltreatment in Adolescents Without Psychopathology , 2017, Neuropsychopharmacology.

[47]  D. Davis,et al.  Distinct Effects of Dexamethasone on Human Natural Killer Cell Responses Dependent on Cytokines , 2017, Front. Immunol..

[48]  C. Weber,et al.  Neutrophils as protagonists and targets in chronic inflammation , 2017 .

[49]  G. Page,et al.  Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period , 2016, Brain, Behavior, and Immunity.

[50]  J. Tolar,et al.  IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function , 2016, Clinical Cancer Research.

[51]  E. Wherry,et al.  Molecular and cellular insights into T cell exhaustion , 2015, Nature Reviews Immunology.

[52]  E. Morand,et al.  GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation. , 2015, Journal of autoimmunity.

[53]  D. Suchecki,et al.  Sleep-deprivation reduces NK cell number and function mediated by β-adrenergic signalling , 2015, Psychoneuroendocrinology.

[54]  Ella Rosenne,et al.  The misleading nature of in vitro and ex vivo findings in studying the impact of stress hormones on NK cell cytotoxicity , 2015, Brain, Behavior, and Immunity.

[55]  R. Flavell,et al.  Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M , 2015, Nature Communications.

[56]  P. Montuschi,et al.  Transcriptional regulation of kinases downstream of the T cell receptor: another immunomodulatory mechanism of glucocorticoids , 2014, BMC Pharmacology and Toxicology.

[57]  E. Rosenne,et al.  In vivo suppression of NK cell cytotoxicity by stress and surgery: Glucocorticoids have a minor role compared to catecholamines and prostaglandins , 2014, Brain, Behavior, and Immunity.

[58]  A. Cato,et al.  Molecular mechanisms of glucocorticoid action in mast cells , 2013, Molecular and Cellular Endocrinology.

[59]  E. Gianchecchi,et al.  Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity. , 2013, Autoimmunity reviews.

[60]  A. Regev,et al.  Dynamic regulatory network controlling Th17 cell differentiation , 2013, Nature.

[61]  P. Kubes,et al.  Neutrophil recruitment and function in health and inflammation , 2013, Nature Reviews Immunology.

[62]  A. Cerwenka,et al.  Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors , 2012, The Journal of experimental medicine.

[63]  A. Vatrella,et al.  The potential of biologics for the treatment of asthma , 2012, Nature Reviews Drug Discovery.

[64]  L. Hurton,et al.  Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells , 2012, PloS one.

[65]  E. Ayroldi,et al.  Manipulating thymic apoptosis for future therapy of autoimmune diseases. , 2011, Current pharmaceutical design.

[66]  P. Chambon,et al.  Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor , 2011, Cell.

[67]  M. Gorospe,et al.  The Human Glucocorticoid Receptor as an RNA-Binding Protein: Global Analysis of Glucocorticoid Receptor-Associated Transcripts and Identification of a Target RNA Motif , 2011, The Journal of Immunology.

[68]  C. Riccardi,et al.  Glucocorticoid‐induced leucine zipper (GILZ): a new important mediator of glucocorticoid action , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[69]  L. Nagy,et al.  Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function , 2008, The EMBO journal.

[70]  R. Gold,et al.  Peripheral T Cells Are the Therapeutic Targets of Glucocorticoids in Experimental Autoimmune Encephalomyelitis1 , 2008, The Journal of Immunology.

[71]  Nianlan Yang,et al.  Glucocorticoid‐induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine‐induced COX‐2 expression , 2008, Journal of cellular biochemistry.

[72]  L. Bäckdahl,et al.  Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells , 2008, Annals of the rheumatic diseases.

[73]  C. Riccardi,et al.  IL-2 Induces an Altered CD4/CD8 Ratio of Splenic T Lymphocytes from Transgenic Mice Overexpressing the Glucocorticoid-Induced Protein GILZ , 2007, Journal of chemotherapy.

[74]  F. Tronche,et al.  Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. , 2007, The Journal of clinical investigation.

[75]  D. Hommes,et al.  Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression. , 2007, Trends in molecular medicine.

[76]  W. Nacken,et al.  Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes. , 2007, Blood.

[77]  J. Cidlowski,et al.  Glucocorticoids Regulate Tristetraprolin Synthesis and Posttranscriptionally Regulate Tumor Necrosis Factor Alpha Inflammatory Signaling , 2006, Molecular and Cellular Biology.

[78]  L. Lanier,et al.  IL-21 Enhances Tumor Rejection through a NKG2D-Dependent Mechanism1 , 2005, The Journal of Immunology.

[79]  C. Riccardi,et al.  Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice. , 2004, Blood.

[80]  C. Akdis,et al.  Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. , 2004, The Journal of allergy and clinical immunology.

[81]  P. Rothman,et al.  Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells , 2004 .

[82]  I. Elenkov.  Glucocorticoids and the Th1/Th2 Balance , 2004, Annals of the New York Academy of Sciences.

[83]  C. Haslett,et al.  Glucocorticoid Augmentation of Macrophage Capacity for Phagocytosis of Apoptotic Cells Is Associated with Reduced p130Cas Expression, Loss of Paxillin/pyk2 Phosphorylation, and High Levels of Active Rac1 , 2001, The Journal of Immunology.

[84]  A. Cumano,et al.  Identification of committed NK cell progenitors in adult murine bone marrow , 2001, European journal of immunology.

[85]  E. Choi,et al.  Inhibition of Cytosolic Phospholipase A2 by Annexin I , 2001, The Journal of Biological Chemistry.

[86]  Scott R. Presnell,et al.  Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function , 2000, Nature.

[87]  K. H. Richter,et al.  The DNA Binding-Independent Function of the Glucocorticoid Receptor Mediates Repression of Ap-1–Dependent Genes in Skin , 1999, The Journal of cell biology.

[88]  M. Caligiuri,et al.  Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. , 1999, Journal of immunology.

[89]  G. Shakhar,et al.  Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity , 1999, International journal of cancer.

[90]  J. M. Cousin,et al.  Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. , 1999, Journal of immunology.

[91]  P. Herrlich,et al.  Transcriptional cross-talk, the second mode of steroid hormone receptor action , 1998, Journal of Molecular Medicine.

[92]  A. Deleo,et al.  Natural killer cell precursors in the CD44neg/dim T-cell receptor population of mouse bone marrow. , 1996, Blood.

[93]  W. Dalton,et al.  Relevance of multidrug resistance to rheumatoid arthritis: development of a new therapeutic hypothesis. , 1996, The Journal of rheumatology. Supplement.

[94]  A. Baldwin,et al.  Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids , 1995, Science.

[95]  A. Deleo,et al.  Role of CD44 in the development of natural killer cells from precursors in long-term cultures of mouse bone marrow. , 1994, Journal of immunology.

[96]  J. Sheridan,et al.  Stress-induced effects on cell-mediated innate and adaptive memory components of the murine immune response to herpes simplex virus infection , 1991, Brain, Behavior, and Immunity.

[97]  J. Sheridan,et al.  Stress-induced suppression of herpes simplex virus (HSV)-specific cytotoxic T lymphocyte and natural killer cell activity and enhancement of acute pathogenesis following local HSV infection , 1991, Brain, Behavior, and Immunity.

[98]  G. Schütz,et al.  A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[99]  E. Gianchecchi,et al.  NK cells in autoimmune diseases: Linking innate and adaptive immune responses. , 2018, Autoimmunity reviews.

[100]  Richard J Simpson,et al.  Exercise and the Regulation of Immune Functions. , 2015, Progress in molecular biology and translational science.

[101]  U. Merschdorf,et al.  High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes. , 2001, Archives of neurology.

[102]  A. Deleo,et al.  Generation of natural killer cells from long-term cultures of mouse bone marrow. , 1993, Natural immunity.