GPI-microdomains: a role in signalling via immunoreceptors.

Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signalling molecules (Src family kinases, G-proteins, linker proteins). Recent results suggest that these membrane specializations mediate not only signal transduction via GPI-proteins and glycolipids but also play important roles in initiation of signalling via immunoreceptors.

[1]  R. Schmidt,et al.  The glycosylphosphatidylinositol‐linked Fcγ receptor III represents the dominant receptor structure for immune complex activation of neutrophils , 1992 .

[2]  C. Peschle,et al.  Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton-insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes. , 1996, Blood.

[3]  A. Lanzavecchia,et al.  T lymphocyte costimulation mediated by reorganization of membrane microdomains. , 1999, Science.

[4]  M. G. Low.  Glycosyl‐phosphatidylinositol: a versatile anchor for cell surface proteins 1 , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  D. Hoessli,et al.  Differential regulation of Src-family protein tyrosine kinases in GPI domains of T lymphocyte plasma membranes. , 1996, Biochemical and biophysical research communications.

[6]  H. Stockinger,et al.  Noncovalent associations of T lymphocyte surface proteins , 1996, European journal of immunology.

[7]  A. Magee,et al.  Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif. , 1997, Journal of cell science.

[8]  K. Jacobson,et al.  Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane. , 1997, Biochemistry.

[9]  L. Wahl,et al.  Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn. , 1993, The Journal of biological chemistry.

[10]  E. Ikonen,et al.  Functional rafts in cell membranes , 1997, Nature.

[11]  B. Baird,et al.  Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains* , 1997, The Journal of Biological Chemistry.

[12]  K. Iwabuchi,et al.  Separation of “Glycosphingolipid Signaling Domain” from Caveolin-containing Membrane Fraction in Mouse Melanoma B16 Cells and Its Role in Cell Adhesion Coupled with Signaling* , 1998, The Journal of Biological Chemistry.

[13]  W. Rodgers,et al.  Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains , 1996, The Journal of cell biology.

[14]  W. Rodgers,et al.  Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction , 1994, Molecular and cellular biology.

[15]  S. Caplan,et al.  Multisubunit receptors in the immune system and their association with the cytoskeleton: In search of functional significance , 1995, Immunologic research.

[16]  H. Stockinger,et al.  Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains , 1998, The Journal of cell biology.

[17]  O. Majdic,et al.  Granulocyte activation via a binding site near the C-terminal region of complement receptor type 3 alpha-chain (CD11b) potentially involved in intramembrane complex formation with glycosylphosphatidylinositol-anchored Fc gamma RIIIB (CD16) molecules. , 1995, Journal of immunology.

[18]  L. Samelson,et al.  LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. , 1998, Immunity.

[19]  W. Knapp,et al.  GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. , 1991, Science.

[20]  T. Kurzchalia,et al.  Microdomains of GPI-anchored proteins in living cells revealed by crosslinking , 1998, Nature.

[21]  M. Cebecauer,et al.  Signal transduction in leucocytes via GPI-anchored proteins: an experimental artefact or an aspect of immunoreceptor function? , 1998, Immunology letters.

[22]  D. Link,et al.  Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae , 1994, The Journal of cell biology.

[23]  H. Petty,et al.  Integrins as promiscuous signal transduction devices. , 1996, Immunology today.

[24]  O. Majdic,et al.  Urokinase plasminogen activator receptor, beta 2-integrins, and Src- kinases within a single receptor complex of human monocytes , 1995, The Journal of experimental medicine.

[25]  M. Hallett,et al.  Exogenous glycosyl phosphatidylinositol-anchored CD59 associates with kinases in membrane clusters on U937 cells and becomes Ca(2+)-signaling competent , 1995, The Journal of cell biology.

[26]  C. Meldrum,et al.  Biochemical isolation of a membrane microdomain from resting platelets highly enriched in the plasma membrane glycoprotein CD36. , 1996, The Biochemical journal.

[27]  I. Trowbridge,et al.  Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts. , 1995, Journal of cell science.

[28]  R. Parton,et al.  Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae. , 1994, The Journal of biological chemistry.

[29]  P. Robinson,et al.  Phosphatidylinositol membrane anchors and T-cell activation. , 1991, Immunology today.

[30]  S. Mayor,et al.  GPI-anchored proteins are organized in submicron domains at the cell surface , 1998, Nature.

[31]  Levi A. Gheber,et al.  Domains in cell plasma membranes investigated by near-field scanning optical microscopy. , 1998, Biophysical journal.

[32]  W. Swaim,et al.  The anti-ganglioside monoclonal antibody AA4 induces protein tyrosine phosphorylations, but not degranulation, in rat basophilic leukemia cells. , 1994, The Journal of biological chemistry.

[33]  Deborah A. Brown,et al.  Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains* , 1998, The Journal of Biological Chemistry.

[34]  K. Iwabuchi,et al.  GM3-enriched Microdomain Involved in Cell Adhesion and Signal Transduction through Carbohydrate-Carbohydrate Interaction in Mouse Melanoma B16 Cells* , 1998, The Journal of Biological Chemistry.

[35]  B. Baird,et al.  Bivalent binding of an anti-CD3 antibody to Jurkat cells induces association of the T cell receptor complex with the cytoskeleton. , 1989, Journal of immunology.

[36]  P. Romagnoli,et al.  Phosphatidylinositol-based glycolipid-anchored proteins enhance proximal TCR signaling events. , 1997, Journal of immunology.

[37]  D. Marguet,et al.  Thymocytes in Thy-1 −/− mice show augmented TCR signaling and impaired differentiation , 1997, Current Biology.

[38]  V. Hořejší,et al.  The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases. , 1992, Journal of immunology.

[39]  Kai Simons,et al.  Interaction of influenza virus haemagglutinin with sphingolipid–cholesterol membrane domains via its transmembrane domain , 1997, The EMBO journal.

[40]  P. Oh,et al.  Separation of caveolae from associated microdomains of GPI-anchored proteins , 1995, Science.

[41]  R. G. Anderson,et al.  Plasmalemmal caveolae and GPI-anchored membrane proteins. , 1993, Current opinion in cell biology.

[42]  R. Xavier,et al.  Membrane compartmentation is required for efficient T cell activation. , 1998, Immunity.

[43]  T. Meyer,et al.  Compartmentalized IgE Receptor–mediated Signal Transduction in Living Cells , 1997, The Journal of cell biology.

[44]  J. Chauvin,et al.  Engagement of T cell receptor triggers its recruitment to low‐density detergent‐insoluble membrane domains , 1998, The EMBO journal.

[45]  D. Hoessli,et al.  Distinct interactions among GPI-anchored, transmembrane and membrane associated intracellular proteins, and sphingolipids in lymphocyte and endothelial cell plasma membranes. , 1997, Biochimica et biophysica acta.

[46]  B. Govindan,et al.  Characterization of the detergent insolubility of the T cell receptor for antigen. , 1997, Molecular immunology.

[47]  T. Brdicka,et al.  T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains. , 1998, Biochemical and biophysical research communications.