Elevation of Lidocaine Seizure Threshold by Gallamine: In Rhesus Monkeys

Arterial plasma lidocaine seizure thresholds were measured in rhesus monkeys, with and without gallamine triethiodide immobilization. Electrical brain activity was recorded by means of chronically-implanted electrodes placed in various cortical and subcortical depths. Immobilized animals had artificial respiration. Lidocaine was administered intravenously (4 mg/kg/ min) until electrical seizure activity began. In 11 experiments on five animals, mean ± standard deviation plasma lidocaine levels at which seizures occurred were 25.5μg/ml±3.0μg/ml in the control group, and 36.2μg/ml± 4.5μg/ml in the group treated with gallamine ( P

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