Computational and experimental prediction of molecules involved in the anti-melanoma action of berberine.

[1]  Gert Vriend,et al.  Increasing the precision of comparative models with YASARA NOVA—a self‐parameterizing force field , 2002, Proteins.

[2]  T. Willson,et al.  Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition , 2002, Cell.

[3]  J. Ashwell,et al.  Activating p38 MAPK: New Tricks for an Old Kinase , 2005, Cell cycle.

[4]  S. Katiyar,et al.  Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. , 2006, Carcinogenesis.

[5]  K. Ramana,et al.  Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. , 2006, Cancer research.

[6]  L. Cipak,et al.  Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. , 2006, Cancer letters.

[7]  Ramkumar Hariharan,et al.  Detailed Comparison of the Protein-Ligand Docking Efficiencies of GOLD, a Commercial Package and ArgusLab, a Licensable Freeware , 2006, Silico Biol..

[8]  Shun-Fa Yang,et al.  Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL , 2007, Archives of Toxicology.

[9]  Takashi Matsumoto,et al.  Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. , 2007, Bioorganic & medicinal chemistry.

[10]  H. Xu,et al.  Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol , 2007, Molecular and Cellular Biology.

[11]  Lenka Gryčová,et al.  Quaternary protoberberine alkaloids. , 2007, Phytochemistry.

[12]  E. Wagner,et al.  p38α: A Suppressor of Cell Proliferation and Tumorigenesis , 2007 .

[13]  B. Shen,et al.  Novel strategies for inhibition of the p38 MAPK pathway. , 2007, Trends in pharmacological sciences.

[14]  P. Baumann,et al.  Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells , 2009, Molecular Cancer Therapeutics.

[15]  C. Sadasivan,et al.  Bisphenol‐A can bind to human glucocorticoid receptor as an agonist: an in silico study , 2010, Journal of applied toxicology : JAT.

[16]  Kai Huang,et al.  PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach , 2010, Nucleic Acids Res..

[17]  J. Tímár,et al.  Glucocorticoid Receptor Expression and Antiproliferative Effect of Dexamethasone on Human Melanoma Cells , 2011, Pathology & Oncology Research.

[18]  K. Ramana,et al.  Inhibition of aldose reductase prevents colon cancer metastasis. , 2011, Carcinogenesis.

[19]  M. Falasca,et al.  Targeting PDK1 in cancer. , 2011, Current medicinal chemistry.

[20]  E. Kassi,et al.  Glucocorticoid receptor signaling and prostate cancer. , 2011, Cancer letters.

[21]  S. Katiyar,et al.  Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors. , 2011, Carcinogenesis.

[22]  Charles Y. Lin,et al.  DHODH modulates transcriptional elongation in the neural crest and melanoma , 2011, Nature.

[23]  V. Vyas,et al.  Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors. , 2011, Mini reviews in medicinal chemistry.

[24]  Young Yang,et al.  Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. , 2012, Biochemical pharmacology.

[25]  Shufeng Zhou,et al.  Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine , 2012, TheScientificWorldJournal.

[26]  R. Den,et al.  Heat shock protein 90 inhibition: rationale and clinical potential , 2012, Therapeutic advances in medical oncology.

[27]  G. Kuttan,et al.  Berberine Inhibits Pulmonary Metastasis through Down‐regulation of MMP in Metastatic B16F‐10 Melanoma Cells , 2012, Phytotherapy research : PTR.

[28]  A. Jemal,et al.  Cancer treatment and survivorship statistics, 2012 , 2012, CA: a cancer journal for clinicians.

[29]  T. Tan,et al.  Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the αvβ3 Integrin and the PKCδ, c-Src, and AP-1 Signaling Pathways , 2013, Evidence-based complementary and alternative medicine : eCAM.

[30]  S. Koul,et al.  Role of p38 MAP Kinase Signal Transduction in Solid Tumors. , 2013, Genes & cancer.

[31]  Y. Yoo,et al.  Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family , 2013, Marine drugs.

[32]  Youyong Li,et al.  Discovery of Rho-kinase inhibitors by docking-based virtual screening. , 2013, Molecular bioSystems.

[33]  Youyong Li,et al.  Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations. , 2013, Molecular bioSystems.

[34]  Tingjun Hou,et al.  Feasibility of Using Molecular Docking-Based Virtual Screening for Searching Dual Target Kinase Inhibitors , 2013, J. Chem. Inf. Model..

[35]  Wei-Jia Kong,et al.  Learning from berberine: Treating chronic diseases through multiple targets , 2015, Science China Life Sciences.

[36]  Tingjun Hou,et al.  Development and Evaluation of an Integrated Virtual Screening Strategy by Combining Molecular Docking and Pharmacophore Searching Based on Multiple Protein Structures , 2013, J. Chem. Inf. Model..

[37]  G. Kristiansen,et al.  Fibroblast Growth Factor Receptor 1 as a Putative Therapy Target in Colorectal Cancer , 2013, Digestion.

[38]  Qian Zhang,et al.  Modeling Compound-Target Interaction Network of Traditional Chinese Medicines for Type II Diabetes Mellitus: Insight for Polypharmacology and Drug Design , 2013, J. Chem. Inf. Model..

[39]  Tingjun Hou,et al.  Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy , 2013, Evidence-based complementary and alternative medicine : eCAM.

[40]  R. Miri,et al.  Comparative amino acid decomposition analysis of potent type I p38α inhibitors , 2013, DARU Journal of Pharmaceutical Sciences.

[41]  Tingjun Hou,et al.  Assessing an Ensemble Docking-Based Virtual Screening Strategy for Kinase Targets by Considering Protein Flexibility , 2014, J. Chem. Inf. Model..

[42]  T. M. Mohan,et al.  Identification of anti-cancer targets of eco-friendly waste Punica granatum peel by dual reverse virtual screening and binding analysis. , 2015, Asian Pacific journal of cancer prevention : APJCP.

[43]  S. Feldon,et al.  Mapracorat, a selective glucocorticoid receptor agonist, upregulates RelB, an anti-inflammatory nuclear factor-kappaB protein, in human ocular cells. , 2014, Experimental eye research.

[44]  C. Lengerke,et al.  Fibroblast growth factor receptor‐1 as a potential therapeutic target in sinonasal cancer , 2014, Head & neck.

[45]  Wei Zhou,et al.  TCMSP: a database of systems pharmacology for drug discovery from herbal medicines , 2014, Journal of Cheminformatics.

[46]  A. Scovassi,et al.  Berberine, an Epiphany Against Cancer , 2014, Molecules.

[47]  Dongping Yuan,et al.  The forecast of anticancer targets of cryptotanshinone based on reverse pharmacophore-based screening technology. , 2014, Chinese journal of natural medicines.

[48]  Y. M. Lee,et al.  Glucocorticoids suppress hypoxia‐induced COX‐2 and hypoxia inducible factor‐1α expression through the induction of glucocorticoid‐induced leucine zipper , 2014, British journal of pharmacology.

[49]  Sihai Wu,et al.  Knockdown of phosphodiesterase 4D inhibits nasopharyngeal carcinoma proliferation via the epidermal growth factor receptor signaling pathway , 2014, Oncology letters.

[50]  F. Zheng,et al.  p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine , 2014, Journal of experimental & clinical cancer research : CR.

[51]  Shao-Jun Chen,et al.  Identification of a potential anticancer target of danshensu by inverse docking. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[52]  J. Wolf,et al.  Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer , 2014, Modern Pathology.

[53]  Hailian Shi,et al.  Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells. , 2014, Oncology reports.

[54]  J. Cui.  Targeting receptor tyrosine kinase MET in cancer: small molecule inhibitors and clinical progress. , 2014, Journal of medicinal chemistry.

[55]  K. Chopra,et al.  Current knowledge and pharmacological profile of berberine: An update. , 2015, European journal of pharmacology.

[56]  J. Gustafsson,et al.  Estrogen receptor mutations and functional consequences for breast cancer , 2015, Trends in Endocrinology & Metabolism.

[57]  C. Nantasenamat,et al.  Computer-Aided Drug Design of Bioactive Natural Products. , 2015, Current topics in medicinal chemistry.

[58]  J. Massagué,et al.  Therapy-induced tumour secretomes promote resistance and tumour progression , 2015, Nature.

[59]  Wei Xiao,et al.  Quantitative modeling of dose–response and drug combination based on pathway network , 2015, Journal of Cheminformatics.

[60]  Hyeong Mi Kim,et al.  Berberine regulates melanin synthesis by activating PI3K/AKT, ERK and GSK3β in B16F10 melanoma cells. , 2015, International journal of molecular medicine.

[61]  H. Im,et al.  Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells , 2015, Oncology reports.

[62]  J. Hao,et al.  Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer , 2015, Medicine.

[63]  M. Pufall.  Glucocorticoids and Cancer. , 2015, Advances in experimental medicine and biology.

[64]  A. Ribas,et al.  Targeted Therapy for Melanoma. , 2016, Cancer treatment and research.

[65]  Kun Wang,et al.  Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. , 2016, Biochemical and biophysical research communications.

[66]  B. Liu,et al.  Calycosin inhibits oxidative stress-induced cardiomyocyte apoptosis via activating estrogen receptor-α/β. , 2016, Bioorganic & medicinal chemistry letters.

[67]  T. Shibata,et al.  Fluorescence assay of dihydroorotate dehydrogenase that may become a cancer biomarker , 2017, Scientific Reports.

[68]  O. Shatrah,et al.  Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells. , 2017, Biochimie.

[69]  A. Puliafito,et al.  Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination , 2017, Cancers.