Analysis of Prescriptions for Dual Antiplatelet Therapy After Acute Ischemic Stroke

Key Points Question Have prescribing patterns in dual antiplatelet therapy (DAPT) for secondary prevention among patients with acute ischemic stroke changed after clinical trial findings and American Heart Association/American Stroke Association practice guideline updates? Findings In this cohort study of 132 817 patients with acute ischemic stroke, 47.0% of patients with minor stroke received DAPT at discharge, as indicated by guidelines; 42.6% patients with nonminor stroke, for whom the risks and benefits of DAPT have not been fully established, received DAPT at discharge, with substantial hospital variation across current US practice. Meaning This study’s findings suggest that enhancing adherence to evidence-based DAPT practice guidelines may be a target for quality improvement in the treatment of patients with ischemic stroke.

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