论文信息 - Oxygen Chiral Phosphate in Ribo- and 2′-Deoxyribodinucleoside Monophosphates by Oxidation of Phosphite Intermediates

Oxygen Chiral Phosphate in Ribo- and 2′-Deoxyribodinucleoside Monophosphates by Oxidation of Phosphite Intermediates

Abstract Oxidation of dinucleoside monophosphite triesters of ribo- and deoxyribonucleosides with iodine-[18O]H2O furnished diastereoisomeric phosphate triesters having the oxygen labels in the P=O group. Chromatographic separation of the isomers followed by deprotection yielded oxygen chiral dinucleoside monophosphates. The absolute configuration of [18O]UpA has been established.

B. Potter | F. Seela | J. Ott | W. Herdering

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