AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration.

[1]  S. Itzkovitz,et al.  Liver zonation. , 2020, Journal of hepatology.

[2]  J. Visvader,et al.  Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis , 2019, Proceedings of the National Academy of Sciences.

[3]  Philipp S. Hoppe,et al.  YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury. , 2019, Cell stem cell.

[4]  R. Nusse,et al.  Tissue repair in the mouse liver following acute carbon tetrachloride depends on injury-induced Wnt/β-catenin signaling , 2018, bioRxiv.

[5]  J. Zucman‐Rossi,et al.  Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations. , 2019, Cell metabolism.

[6]  S. Forbes,et al.  Hepatocyte‐Specific β‐Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes , 2019, Hepatology.

[7]  L. Hui,et al.  Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes. , 2018, Cell stem cell.

[8]  Sucha Singh,et al.  Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation , 2018, Hepatology communications.

[9]  Kari A. Huppert,et al.  De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation , 2018, Nature.

[10]  S. Artandi,et al.  Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury , 2018, Nature.

[11]  Jacquelyn O. Russell,et al.  Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology. , 2018, Annual review of pathology.

[12]  A. Saadatpour,et al.  Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. , 2017, Cell stem cell.

[13]  Wei-Yu Lu,et al.  Cholangiocytes act as Facultative Liver Stem Cells during Impaired Hepatocyte Regeneration , 2017, Nature.

[14]  A. Miyajima,et al.  Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling , 2016, eLife.

[15]  S. Schuierer,et al.  The exon quantification pipeline (EQP): a comprehensive approach to the quantification of gene, exon and junction expression from RNA-seq data , 2016, Nucleic acids research.

[16]  A. Donovan,et al.  The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size , 2016, Nature Cell Biology.

[17]  H. Okamoto,et al.  The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation. , 2015, Cell reports.

[18]  K. Deisseroth,et al.  Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer , 2015, Cell.

[19]  R. Nusse,et al.  Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver , 2015, Nature.

[20]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[21]  M. Grompe,et al.  Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. , 2014, Cell stem cell.

[22]  Lars Juhl Jensen,et al.  Cyclebase 3.0: a multi-organism database on cell-cycle regulation and phenotypes , 2014, Nucleic Acids Res..

[23]  Alessandro Vullo,et al.  Ensembl 2015 , 2014, Nucleic Acids Res..

[24]  Cassandra R Diegel,et al.  Beta‐catenin signaling in murine liver zonation and regeneration: A Wnt‐Wnt situation! , 2014, Hepatology.

[25]  M. Grompe,et al.  Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury , 2014, Hepatology.

[26]  P. Veber,et al.  T‐cell factor 4 and β‐catenin chromatin occupancies pattern zonal liver metabolism in mice , 2014, Hepatology.

[27]  A. Miyajima,et al.  Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. , 2014, Cell stem cell.

[28]  R. Wells,et al.  Robust cellular reprogramming occurs spontaneously during liver regeneration. , 2013, Genes & development.

[29]  I. Leclercq,et al.  Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. , 2012, Gastroenterology.

[30]  G. Smyth,et al.  Camera: a competitive gene set test accounting for inter-gene correlation , 2012, Nucleic acids research.

[31]  B. Stanger,et al.  Facultative stem cells in liver and pancreas: Fact and fancy , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

[32]  Satdarshan P. S. Monga,et al.  Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. , 2011, Seminars in cancer biology.

[33]  M. Robinson,et al.  A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.

[34]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[35]  S. Feng,et al.  Liver‐specific loss of β‐catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice , 2006, Hepatology.

[36]  M. Capecchi,et al.  Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo , 2006, Development.

[37]  G. Michalopoulos,et al.  Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury , 2005, Hepatology.

[38]  Y. Magami,et al.  Cell proliferation and renewal of normal hepatocytes and bile duct cells in adult mouse liver. , 2002, Liver.

[39]  David I. Smith,et al.  Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas , 2002, Oncogene.

[40]  Hans Clevers,et al.  Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors , 2002, Molecular and Cellular Biology.

[41]  Choun-Ki Joo,et al.  Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway , 2002, Molecular and Cellular Biology.

[42]  A. Tarnawski,et al.  Apoptosis in the gastric mucosa: molecular mechanisms, basic and clinical implications. , 2000, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[43]  A. Ramachandran,et al.  Apoptosis in the intestinal epithelium: Its relevance in normal and pathophysiological conditions , 2000, Journal of gastroenterology and hepatology.

[44]  G. Michalopoulos,et al.  Liver Regeneration , 1997, Journal of cellular physiology.

[45]  K. Kaestner,et al.  Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. , 2015, Gastroenterology.

[46]  H. Willenbring,et al.  A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice , 2008, Nature Protocols.

[47]  Philippe Soriano Generalized lacZ expression with the ROSA26 Cre reporter strain , 1999, Nature Genetics.

[48]  G. Michalopoulos,et al.  Liver Regeneration , 1997, Science.

[49]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .