A miR-124-mediated post-transcriptional mechanism controlling the cell fate switch of astrocytes to induced-neurons

[1]  R. Barker,et al.  Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease , 2022, Stem cell reports.

[2]  Malte D. Luecken,et al.  Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons , 2022, EMBO molecular medicine.

[3]  B. Berninger,et al.  Reprogramming cellular identity in vivo. , 2022, Development.

[4]  M. Götz,et al.  Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches , 2021, Neuron.

[5]  Chun-li Zhang,et al.  Revisiting astrocyte to neuron conversion with lineage tracing in vivo , 2021, Cell.

[6]  K. Conzelmann,et al.  Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy , 2021, Cell stem cell.

[7]  W. Lin,et al.  Progenitor cell diversity in the developing mouse neocortex , 2021, Proceedings of the National Academy of Sciences.

[8]  Z. Israel,et al.  Reversing a Model of Parkinson's Disease With In Situ Converted Nigral Neurons , 2020, Movement disorders : official journal of the Movement Disorder Society.

[9]  Dongyang Zhang,et al.  Reversing a model of Parkinson’s disease with in situ converted nigral neurons , 2020, Nature.

[10]  Dongyang Zhang,et al.  Reversing Parkinson Disease Model with in situ Converted Nigral Neurons , 2020, Nature.

[11]  Huatai Xu,et al.  Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice , 2020, Cell.

[12]  A. Yoo,et al.  MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity , 2020, bioRxiv.

[13]  Zheng Wu,et al.  Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease , 2020, Nature Communications.

[14]  Satdarshan P. S. Monga,et al.  β‐Catenin Signaling , 2020 .

[15]  R. Barker,et al.  Dual modulation of neuron‐specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons , 2019, FEBS letters.

[16]  M. Götz,et al.  Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex , 2019, Neuron.

[17]  Yi Hu,et al.  A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion , 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  Xinran Dong,et al.  Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. , 2019, Cell stem cell.

[19]  L. Garcia-Segura,et al.  Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge , 2019, Cell Death Discovery.

[20]  K. Shirahige,et al.  Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion , 2019, Neuron.

[21]  Astrid Gall,et al.  Ensembl 2019 , 2018, Nucleic Acids Res..

[22]  D. Black,et al.  Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse , 2018, Proceedings of the National Academy of Sciences.

[23]  A. Hatzigeorgiou,et al.  microCLIP super learning framework uncovers functional transcriptome-wide miRNA interactions , 2018, Nature Communications.

[24]  Robert F. Hevner,et al.  The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1 , 2018, Front. Neurosci..

[25]  Qiang Liu,et al.  Direct , 2018, Definitions.

[26]  A. Yoo,et al.  MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts. , 2018, Developmental cell.

[27]  Matheus B. Victor,et al.  Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes , 2018, Nature Neuroscience.

[28]  Ken-ichi Mizutani.  Physiological significance of multipolar cells generated from neural stem cells and progenitors for the establishment of neocortical cytoarchitecture , 2018, Genes to cells : devoted to molecular & cellular mechanisms.

[29]  Gary D Bader,et al.  Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling. , 2017, Cell reports.

[30]  J. Dougherty,et al.  MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. , 2017, Cell stem cell.

[31]  S. Linnarsson,et al.  Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model , 2017, Nature Biotechnology.

[32]  Amanda J. Kedaigle,et al.  Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice , 2017, Nature Neuroscience.

[33]  X. Bian,et al.  Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules , 2017, Stem cell reports.

[34]  A. Kalsotra.  Faculty Opinions recommendation of HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. , 2016 .

[35]  H. Ahlfors,et al.  The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression , 2016, The Journal of Immunology.

[36]  B. Christie,et al.  ISX-9 can potentiate cell proliferation and neuronal commitment in the rat dentate gyrus , 2016, Neuroscience.

[37]  Lior Pachter,et al.  Differential analysis of RNA-seq incorporating quantification uncertainty , 2016, Nature Methods.

[38]  Manuel D. Díaz-Muñoz,et al.  RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence , 2016, Science.

[39]  Lior Pachter,et al.  Near-optimal probabilistic RNA-seq quantification , 2016, Nature Biotechnology.

[40]  S. Robertson,et al.  Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming. , 2016, Cell stem cell.

[41]  Avi Ma'ayan,et al.  Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain , 2016, eLife.

[42]  Hong Wang,et al.  LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain , 2016, Nature Communications.

[43]  T. Reh,et al.  miR-124-9-9* Potentiates Ascl1-Induced Reprogramming of Cultured M€uller Glia , 2016, Glia.

[44]  D. Geschwind,et al.  Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes , 2016, Neuron.

[45]  P. Smialowski,et al.  NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program , 2016, The EMBO journal.

[46]  Ping Zhong,et al.  Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons , 2015, Nature Communications.

[47]  P. Jin,et al.  Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. , 2015, Cell stem cell.

[48]  Lei Dong,et al.  ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6 , 2015, Scientific Reports.

[49]  E. Glaab,et al.  Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation , 2015, Molecular Neurobiology.

[50]  B. Berninger,et al.  CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons , 2015, Stem cell reports.

[51]  Xiang Li,et al.  Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. , 2015, Cell stem cell.

[52]  Weijun Dai,et al.  A post-transcriptional mechanism pacing expression of neural genes with precursor cell differentiation status , 2015, Nature Communications.

[53]  Magdalena Götz,et al.  Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome‐wide expression analysis , 2015, Glia.

[54]  A. Dahl,et al.  Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis , 2015, The EMBO journal.

[55]  Matheus B. Victor,et al.  Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts , 2014, Neuron.

[56]  Jonas Frisén,et al.  A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse , 2014, Science.

[57]  T. Maniatis,et al.  An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex , 2014, The Journal of Neuroscience.

[58]  Sheng Xiong. Neo,et al.  MicroRNA miR-124 Controls the Choice between Neuronal and Astrocyte Differentiation by Fine-tuning Ezh2 Expression* , 2014, The Journal of Biological Chemistry.

[59]  L. Nguyen,et al.  MicroRNA targeting of CoREST controls polarization of migrating cortical neurons. , 2014, Cell reports.

[60]  Michael Q. Zhang,et al.  HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. , 2014, Cell reports.

[61]  Lei Zhang,et al.  In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model. , 2014, Cell stem cell.

[62]  Yi Xing,et al.  Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain , 2014, Neuron.

[63]  R. Bachoo,et al.  In vivo reprogramming of astrocytes to neuroblasts in the adult brain , 2013, Nature Cell Biology.

[64]  R. Hart,et al.  Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons , 2013, Neuroscience.

[65]  Eva Díaz-Guerra,et al.  Transcriptional Regulation of Olfactory Bulb Neurogenesis , 2013, Anatomical record.

[66]  Anton J. Enright,et al.  Kraken: A set of tools for quality control and analysis of high-throughput sequence data , 2013, Methods.

[67]  B. Aronow,et al.  Environmental Impact on Direct Neuronal Reprogramming In Vivo in the Adult Brain , 2013, Nature Communications.

[68]  L. Tsai,et al.  Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. , 2013, Cell stem cell.

[69]  A. Björklund,et al.  Generation of induced neurons via direct conversion in vivo , 2013, Proceedings of the National Academy of Sciences.

[70]  Yi Zhang,et al.  Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits , 2013, Cell.

[71]  A. Mele,et al.  Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability , 2012, Neuron.

[72]  D. Trono,et al.  MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant , 2012, The Journal of Neuroscience.

[73]  N. Šestan,et al.  Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex , 2012, Development.

[74]  Deric M. Park,et al.  β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas , 2012, Proceedings of the National Academy of Sciences.

[75]  R. Blelloch.  Faculty Opinions recommendation of MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. , 2012 .

[76]  M. Cobb,et al.  A small molecule differentiation inducer increases insulin production by pancreatic β cells , 2011, Proceedings of the National Academy of Sciences.

[77]  Leonard D. Goldstein,et al.  miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones , 2011, Nature Neuroscience.

[78]  D. Watanabe,et al.  miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression , 2011, Nature Neuroscience.

[79]  Li Li,et al.  MicroRNA-mediated conversion of human fibroblasts to neurons , 2011, Nature.

[80]  Marcel Martin.  Cutadapt removes adapter sequences from high-throughput sequencing reads , 2011 .

[81]  J. Hébert,et al.  Signaling Pathways in Reactive Astrocytes, a Genetic Perspective , 2011, Molecular Neurobiology.

[82]  Jane Y. Wu,et al.  MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1 , 2010, Nucleic acids research.

[83]  M. Götz,et al.  Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons , 2010, PLoS biology.

[84]  P. Jin,et al.  Roles of small regulatory RNAs in determining neuronal identity , 2010, Nature Reviews Neuroscience.

[85]  Serban Nacu,et al.  Fast and SNP-tolerant detection of complex variants and splicing in short reads , 2010, Bioinform..

[86]  N. Maiorano,et al.  Promotion of embryonic cortico-cerebral neuronogenesis by miR-124 , 2009, Neural Development.

[87]  K. Nave,et al.  Neurod1 is essential for the survival and maturation of adult-born neurons , 2009, Nature Neuroscience.

[88]  G. Crabtree,et al.  MicroRNA-mediated switching of chromatin-remodelling complexes in neural development , 2009, Nature.

[89]  A. Mele,et al.  Ago HITS-CLIP decodes miRNA-mRNA interaction maps , 2009, Nature.

[90]  Erika Pastrana,et al.  miR-124 regulates adult neurogenesis in the SVZ stem cell niche , 2009, Nature Neuroscience.

[91]  I. Bezprozvanny,et al.  Small-molecule activation of neuronal cell fate. , 2008, Nature chemical biology.

[92]  B. Grothe,et al.  Functional Properties of Neurons Derived from In Vitro Reprogrammed Postnatal Astroglia , 2007, The Journal of Neuroscience.

[93]  T. Maniatis,et al.  The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. , 2007, Molecular cell.

[94]  P. Blackshear,et al.  Comparative expression of tristetraprolin (TTP) family member transcripts in normal human tissues and cancer cell lines. , 2007, Archives of biochemistry and biophysics.

[95]  Y. Hsueh,et al.  Cytoplasmic distribution of T-box transcription factor Tbr-1 in adult rodent brain , 2007, Journal of Chemical Neuroanatomy.

[96]  Jae W. Lee,et al.  The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. , 2007, Genes & development.

[97]  D. Turner,et al.  Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[98]  R. Shigemoto,et al.  Glutamate and GABA receptor signalling in the developing brain , 2005, Neuroscience.

[99]  P. Blackshear,et al.  Interactions of CCCH Zinc Finger Proteins with mRNA , 2002, The Journal of Biological Chemistry.

[100]  P. Blackshear,et al.  Interactions of CCCH Zinc Finger Proteins with mRNA , 2000, The Journal of Biological Chemistry.

[101]  M. Mehler,et al.  Bone Morphogenetic Proteins Promote Astroglial Lineage Commitment by Mammalian Subventricular Zone Progenitor Cells , 1996, Neuron.

[102]  A. Mccarthy.  Development , 1996, Current Opinion in Neurobiology.

[103]  Howard Rosenbaum,et al.  Effects of reading proficiency on embedded stem priming in primary school children , 2021 .

[104]  Neil Ingham,et al.  Environmental impact: What? , 1974 .

[105]  H. Yao,et al.  Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice , 2020 .

[106]  J. Hébert,et al.  Signaling Pathways in Reactive Astrocytes, a Genetic , 2011 .

[107]  S. Lipton,et al.  Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. , 2011, Cell stem cell.

[108]  G. Crabtree,et al.  MicroRNA-mediated switching of chromatin-remodelling complexes in neural development , 2009, Nature.

[109]  Danielle M. Santarelli,et al.  The Developing Brain , 2017 .