Treatment of autistic disorder.

OBJECTIVE To present an overview of a variety of treatment approaches in individuals with autistic disorder. METHOD Selected studies and articles are reviewed. RESULTS In the past three decades, great progress has been made in the treatment of autistic disorder, particularly in the area of education and parental involvement, with the objective to transfer to home and in other situations learning acquired in school. A role for psychoactive agents, when combined with psychosocial treatments, has been identified. CONCLUSIONS Although considerable advances have been made in a variety of interventions-educational, psychosocial, and biological-knowledge about the comparative and combined efficacy of the various treatment modalities is lacking. From the parents' perspective, particularly, support and continuity of services require improvement.

[1]  S. Edelson,et al.  Brief report: A pilot study of auditory integration training in autism , 1995, Journal of autism and developmental disorders.

[2]  J. Rapoport,et al.  A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) , 1989, The New England journal of medicine.

[3]  Eric Schopler,et al.  Learning and cognition in autism , 1995 .

[4]  E. Schopler,et al.  Behavioral Issues in Autism , 1994 .

[5]  M. Falvey Community-Based Curriculum: Instructional Strategies for Students With Severe Handicaps , 1986 .

[6]  A. Hudson,et al.  Brief report: A case study assessing the validity of facilitated communication , 1993, Journal of autism and developmental disorders.

[7]  L. Koegel,et al.  Extended reductions in stereotypic behavior of students with autism through a self-management treatment package. , 1990, Journal of applied behavior analysis.

[8]  R. Perry,et al.  Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms. , 1984, The American journal of psychiatry.

[9]  Aubyn C. Stahmer,et al.  Teaching children with autism appropriate play in unsupervised environments using a self-management treatment package. , 1992, Journal of applied behavior analysis.

[10]  B. Leventhal,et al.  Fenfluramine treatment of autism: UCLA collaborative study of 81 patients at nine medical centers. , 1986, Psychopharmacology bulletin.

[11]  O. I. Lovaas,et al.  The autistic child: Language development through behavior modification. , 1977 .

[12]  M. Rutter,et al.  Special educational treatment of autistic children: a comparative study. 1. Design of study and characteristics of units. , 1973, Journal of child psychology and psychiatry, and allied disciplines.

[13]  E. Schopler,et al.  Thought disorders in parents of psychotic children. A function of test anxiety. , 1969, Archives of general psychiatry.

[14]  L. Casey,et al.  Development of communicative behavior in autistic children: A parent program using manual signs , 1978, Journal of autism and childhood schizophrenia.

[15]  Anthony J. Plienis,et al.  Consistent stress profiles in mothers of children with autism , 1992, Journal of autism and developmental disorders.

[16]  L. Wing Social and Interpersonal Needs , 1983 .

[17]  J. Overall,et al.  Factors related to haloperidol response and dyskinesias in autistic children. , 1991, Psychopharmacology bulletin.

[18]  E. Corfman Families Today: A Research Sampler on Families and Children. Volume II. NIMH Science Monographs 1. , 1981 .

[19]  J. Overall,et al.  Tardive and withdrawal dyskinesia in autistic children: a prospective study. , 1988, Psychopharmacology bulletin.

[20]  E. Schopler A Statewide Program for the Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH) , 1994 .

[21]  M. Chung,et al.  The path to care in autism: Is it better now? , 1994, Journal of autism and developmental disorders.

[22]  B. Freeman,et al.  Effects of fenfluramine on 14 outpatients with the syndrome of autism. , 1983, Journal of the American Academy of Child Psychiatry.

[23]  J. Overall,et al.  Long-term efficacy of haloperidol in autistic children: continuous versus discontinuous drug administration. , 1989, Journal of the American Academy of Child and Adolescent Psychiatry.

[24]  Susan L. Smith Competitive Employment Issues and Strategies , 1987 .

[25]  C B FERSTER,et al.  The development of performances in autistic children in an automatically controlled environment. , 1961, Journal of chronic diseases.

[26]  E. Schopler,et al.  Parents as cotherapists in the treatment of psychotic children , 1971, Journal of autism and childhood schizophrenia.

[27]  H. Gardner The mind's new science: a history of the cognitive revolution , 1985 .

[28]  L. Anderson,et al.  Pharmacotherapy in autism. A summary of research at Bellevue/New York University , 1990 .

[29]  M. Charlop,et al.  Increasing autistic children's spontaneous verbalizations of affection: an assessment of time delay and peer modeling procedures. , 1986, Journal of applied behavior analysis.

[30]  L. E. Arnold,et al.  Beta blockers in mental retardation and developmental disorders. , 1991, Journal of child and adolescent psychopharmacology.

[31]  C. Lord Early Social Development in Autism , 1993 .

[32]  Christopher Gillberg,et al.  Diagnosis and Treatment of Autism , 1989, Springer US.

[33]  Developing a social communication curriculum for autistic students , 1982 .

[34]  J. Panksepp,et al.  Brain opioids and autism: An updated analysis of possible linkages , 1987, Journal of autism and developmental disorders.

[35]  A. Short,et al.  Short-term treatment outcome using parents as co-therapists for their own autistic children. , 1984, Journal of child psychology and psychiatry, and allied disciplines.

[36]  H. Quay,et al.  Psychopathological disorders of childhood , 1979 .

[37]  J. Matson,et al.  Increasing spontaneous language in three autistic children. , 1990, Journal of applied behavior analysis.

[38]  J. Bemporad,et al.  Autism: The Treatment of Aggressive Behaviors , 1987, Journal of clinical psychopharmacology.

[39]  J. Locascio,et al.  Pimozide in autistic children. , 1992, Psychopharmacology bulletin.

[40]  C. Gregory Comprehensive Textbook of Psychiatry/VI , 1996 .

[41]  E. Schopler,et al.  Structured Teaching in the TEACCH System , 1995 .

[42]  J. Overall,et al.  Naltrexone in autistic children: an acute open dose range tolerance trial. , 1989, Journal of the American Academy of Child and Adolescent Psychiatry.

[43]  T. Shapiro,et al.  Long-term prognosis and the response of schizophrenic children to drug therapy: a controlled study of trifluoperazine. , 1966, The American journal of psychiatry.

[44]  R. Koegel,et al.  Self-Management of Problematic Social Behavior , 1994 .

[45]  C. B. Ferster,et al.  A method for the experimental analysis of the behavior of autistic children. , 1962, American Journal of Orthopsychiatry.

[46]  L. Schreibman,et al.  Increasing spontaneous verbal responding in autistic children using a time delay procedure. , 1985, Journal of applied behavior analysis.

[47]  M. Campbell,et al.  A pilot study of clomipramine in young autistic children. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[48]  I. Cohen,et al.  A comparison of haloperidol and behavior therapy and their interaction in autistic children. , 1978, Journal of the American Academy of Child Psychiatry.

[49]  L. Kanner Autistic disturbances of affective contact. , 1968, Acta paedopsychiatrica.

[50]  B. Leventhal,et al.  Clinical and neurochemical effects of fenfluramine in children with autism. , 1993, The Journal of neuropsychiatry and clinical neurosciences.

[51]  Eric Schopier,et al.  Teaching Spontaneous Communication to Autistic and Developmentally Handicapped Children , 1988 .

[52]  C. Lord Facilitating Social Inclusion , 1995 .

[53]  J. Rapoport,et al.  A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting). , 1991, Archives of general psychiatry.

[54]  J. Overall,et al.  Behavioral assessment of psychopathology in children: infantile autism. , 1988, Journal of Clinical Psychology.

[55]  Eric Schopler,et al.  Autism in adolescents and adults , 1983 .

[56]  M. Ernst,et al.  Naltrexone in autistic children: behavioral symptoms and attentional learning. , 1993, Journal of the American Academy of Child and Adolescent Psychiatry.

[57]  M Linnoila,et al.  Clomipramine treatment of childhood obsessive-compulsive disorder. A double-blind controlled study. , 1985, Archives of general psychiatry.

[58]  H. Feldman,et al.  Naltrexone in young autistic children: a double-blind, placebo-controlled crossover study. , 1995, Journal of the American Academy of Child and Adolescent Psychiatry.

[59]  E. Schopler,et al.  Improvement of teaching effectiveness in parents of autistic children. , 1978, Journal of the American Academy of Child Psychiatry.

[60]  M. Aman Efficacy of psychotropic drugs for reducing self-injurious behavior in the developmental disabilities. , 1993, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[61]  E. Schopler,et al.  Preschool issues in autism , 1993 .

[62]  M. Campbell,et al.  A comparison of live and videotape ratings: clomipramine and haloperidol in autism. , 1995, Psychopharmacology bulletin.

[63]  E. Schopler,et al.  Developmental Therapy: A Program Model for Providing Individual Services in the Community , 1976 .

[64]  M. Rutter Autistic children: infancy to adulthood. , 1970, Seminars in psychiatry.

[65]  B. Leventhal,et al.  Clonidine Treatment of Hyperactive and Impulsive Children with Autistic Disorder , 1992, Journal of clinical psychopharmacology.

[66]  M. Campbell Fenfluramine treatment of autism. , 1988, Journal of child psychology and psychiatry, and allied disciplines.

[67]  Bernard Rimland,et al.  Infantile Autism , 2014, Companion Encyclopedia of Psychology.

[68]  R. P. Hobson On psychoanalytic approaches to autism. , 1990, The American journal of orthopsychiatry.

[69]  E. Schopler Behavioral Priorities for Autism and Related Developmental Disorders , 1994 .

[70]  C. B. Ferster Positive reinforcement and behavioral deficits of autistic children. , 1961, Child development.

[71]  C. Gillberg,et al.  Fenfluramine treatment of twenty children with autism , 1989, Journal of autism and developmental disorders.

[72]  Eric Schopler,et al.  The effects of autism on the family , 1984 .

[73]  Autism in Children and Adults: Etiology, Assessment, and Intervention , 1994 .

[74]  M K DeMyer,et al.  Infantile autism reviewed: a decade of research. , 1981, Schizophrenia bulletin.

[75]  I. Cohen,et al.  A study of haloperidol in young autistic children: a within-subjects design using objective rating scales. , 1980, Psychopharmacology bulletin.

[76]  Eric Schopler Principles for Directing Both Educational Treatment and Research , 1989 .

[77]  J. Wiener Diagnosis and psychopharmacology of childhood and adolescent disorders , 1997 .

[78]  O. I. Lovaas,et al.  Behavioral treatment and normal educational and intellectual functioning in young autistic children. , 1987, Journal of consulting and clinical psychology.

[79]  M. Smith,et al.  Brief report: Facilitated communication with adults with autism , 1993, Journal of Autism and Developmental Disorders.

[80]  B. Bettelheim,et al.  The Empty Fortress: Infantile Autism and the Birth of the Self , 1972 .

[81]  J. Whyte,et al.  The Incidence of Seizures during Tricyclic Antidepressant Drug Treatment in a Brain-Injured Population , 1990, Journal of clinical psychopharmacology.

[82]  M. Campbell,et al.  Haloperidol-related dyskinesias and pre- and perinatal complications in autistic children. , 1995, Psychopharmacology bulletin.

[83]  R. Perry,et al.  The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children , 1989, Journal of autism and developmental disorders.

[84]  D. Cohen,et al.  Clonidine treatment of Gilles de la Tourette's syndrome. , 1991, Archives of general psychiatry.

[85]  R. Hales,et al.  J Neuropsychiatry Clin Neurosci , 1992 .

[86]  R. Hobson Beyond cognition: A theory of autism. , 1989 .

[87]  J. Panksepp A neurochemical theory of autism , 1979, Trends in Neurosciences.

[88]  J. Rapoport,et al.  A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. , 1993, Archives of general psychiatry.

[89]  Robert E. Cummins,et al.  Questions about facilitated communication and autism , 1992, Journal of autism and developmental disorders.

[90]  J. Locascio,et al.  Repeated episodes of neuroleptic-related dyskinesias in autistic children. , 1991, Psychopharmacology bulletin.

[91]  E. Schopler,et al.  Evaluation of treatment for autistic children and their parents. , 1982, Journal of the American Academy of Child Psychiatry.

[92]  O. I. Lovaas,et al.  A comprehensive behavioral theory of autistic children: paradigm for research and treatment. , 1989, Journal of behavior therapy and experimental psychiatry.

[93]  W. S. Condon,et al.  Multiple response to sound in dysfunctional children , 1975, Journal of autism and childhood schizophrenia.

[94]  A. Yates,et al.  A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism. , 1992, The Journal of clinical psychiatry.

[95]  D. Biklen,et al.  Communication Unbound: Autism and Praxis , 1990 .

[96]  E. Anderson Hudson et al. , 1977 .

[97]  Past and present trends in residential treatment , 1990, Journal of autism and developmental disorders.

[98]  W. H. Green,et al.  Neuroleptic-induced dyskinesias in children. , 1983, Clinical neuropharmacology.

[99]  H. Jick,et al.  Antidepressants and convulsions. , 1992, Journal of clinical psychopharmacology.

[100]  Relation of behavioral treatment to "normal functioning": comment on Lovaas. , 1989 .

[101]  B. Birmaher,et al.  CASE STUDY Methylphenidate Treatment of Hyperactive Autistic Children , 1988 .

[102]  J. Overall,et al.  Efficacy and safety of fenfluramine in autistic children. , 1988, Journal of the American Academy of Child and Adolescent Psychiatry.

[103]  O. I. Lovaas,et al.  Long-term outcome for children with autism who received early intensive behavioral treatment. , 1993, American journal of mental retardation : AJMR.