Emodin attenuates high lipid-induced liver metastasis through the AKT and ERK pathways in vitro in breast cancer cells and in a mouse xenograft model

[1]  Z. Fu,et al.  ICAM1 promotes bone metastasis via integrin‐mediated TGF‐β/EMT signaling in triple‐negative breast cancer , 2022, Cancer science.

[2]  M. Rivera,et al.  CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation , 2022, The Journal of experimental medicine.

[3]  Xixi Lin,et al.  Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities , 2022, Cancer communications.

[4]  Zimei Yang,et al.  GeneChip expression profiling identified OLFML2A as a potential therapeutic target in TNBC cells , 2022, Annals of translational medicine.

[5]  Meden F. Isaac-Lam.  Molecular modeling of the interaction of ligands with ACE2–SARS-CoV-2 spike protein complex , 2021, In Silico Pharmacology.

[6]  Hefen Sun,et al.  NSDHL promotes triple-negative breast cancer metastasis through the TGFβ signaling pathway and cholesterol biosynthesis , 2021, Breast Cancer Research and Treatment.

[7]  A. Jemal,et al.  Cancer Statistics, 2021 , 2021, CA: a cancer journal for clinicians.

[8]  Jonathan R. Brestoff,et al.  Hepatic lipids promote liver metastasis , 2020, JCI insight.

[9]  X. Liu,et al.  Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer , 2020, The EMBO journal.

[10]  Qi-xun Cai,et al.  Integrated Bioinformatics Analysis Reveals Potential Pathway Biomarkers and Their Interactions for Clubfoot , 2020, Medical science monitor : international medical journal of experimental and clinical research.

[11]  J. Katzenellenbogen,et al.  Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling. , 2019, Cancer research.

[12]  M. Borad,et al.  Hepatocytes direct the formation of a pro-metastatic niche in the liver. , 2019, Nature.

[13]  Xiqiu Zhou,et al.  Emodin inhibits epithelial‑mesenchymal transition and metastasis of triple negative breast cancer via antagonism of CC‑chemokine ligand 5 secreted from adipocytes. , 2018, International journal of molecular medicine.

[14]  Jian Zhang,et al.  Fatty liver decreases the risk of liver metastasis in patients with breast cancer: a two-center cohort study , 2017, Breast Cancer Research and Treatment.

[15]  Shaojie Wang,et al.  Emodin alleviates hepatic steatosis by inhibiting sterol regulatory element binding protein 1 activity by way of the calcium/calmodulin‐dependent kinase kinase–AMP‐activated protein kinase–mechanistic target of rapamycin–p70 ribosomal S6 kinase signaling pathway , 2017, Hepatology research : the official journal of the Japan Society of Hepatology.

[16]  M. Prentki,et al.  Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells. , 2017, JCI insight.

[17]  K. Jang,et al.  CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients. , 2016, The American journal of pathology.

[18]  Jian Ni,et al.  Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics , 2016, Phytotherapy research : PTR.

[19]  Stephen L. Johnson,et al.  Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts. , 2016, Cell chemical biology.

[20]  Li Yang,et al.  Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway. , 2016, European journal of pharmacology.

[21]  Xinyu Zheng,et al.  Emodin induces apoptosis of human breast cancer cells by modulating the expression of apoptosis-related genes. , 2015, Oncology letters.

[22]  M. Ozkan,et al.  Hepatic steatosis is associated with higher incidence of liver metastasis in patients with metastatic breast cancer; an observational clinical study. , 2015, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[23]  Shan Wang,et al.  The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer. , 2015, International journal of oncology.

[24]  G. K. Gray,et al.  Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells , 2014, Oncotarget.

[25]  Y. Qi,et al.  Effects of Obesity on Transcriptomic Changes and Cancer Hallmarks in Estrogen Receptor–Positive Breast Cancer , 2014, Journal of the National Cancer Institute.

[26]  A. McTiernan,et al.  Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies , 2014, Annals of oncology : official journal of the European Society for Medical Oncology.

[27]  Jun Hu,et al.  Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides , 2014, Experimental biology and medicine.

[28]  Chih-Yang Huang,et al.  Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ERα Inhibition , 2013, Evidence-based complementary and alternative medicine : eCAM.

[29]  S. Ryu,et al.  Emodin Regulates Glucose Utilization by Activating AMP-activated Protein Kinase* , 2013, The Journal of Biological Chemistry.

[30]  Lu Zhang,et al.  Promotion of adiponectin multimerization by emodin: A novel AMPK activator with PPARγ‐agonist activity , 2012, Journal of cellular biochemistry.

[31]  S. Mandrup,et al.  Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes. , 2012, The Journal of nutritional biochemistry.

[32]  L. Pinna,et al.  Addiction to protein kinase CK2: a common denominator of diverse cancer cells? , 2010, Biochimica et biophysica acta.

[33]  Songtao Yu,et al.  Review Nuclear Receptor Signaling | The Open Access Journal of the Nuclear Receptor Signaling Atlas PPARα: energy combustion, hypolipidemia, inflammation and cancer , 2022 .

[34]  Keji Chen,et al.  Emodin promotes atherosclerotic plaque stability in fat-fed apolipoprotein E-deficient mice. , 2008, The Tohoku journal of experimental medicine.

[35]  W. Willett,et al.  Adult weight change and risk of postmenopausal breast cancer. , 2006, JAMA.

[36]  R. Cardiff,et al.  Protein kinase CK2 in mammary gland tumorigenesis , 2001, Oncogene.

[37]  M. Ewertz,et al.  Effect of obesity on prognosis after early-stage breast cancer. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.