We discuss the clinical features of 12 cases of resected colon cancer associated with primary cancer of the uterus. In a recent 17-year period, 517 patients with colon cancer were operated at our department; and 45 patients were associated with extracolonic cancer including 12 patients with uterus cancer which occurred most frequently in female cases. Ten of 12 cases of colon cancer associated with uterus cancer have family history of cancer. In two of three patients who had colon cancer after radiation for uterus cancer, the colon cancer occurred within the field of radiation. One case revealed pathological features similar to radiation induced intestinal damage. In cases of uterus cancer with family history of cancer or history of irradiation, strict surveillance is considered to be required against second malignancies of the colon.
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