Analysis of clinical effect of high-intensity focused ultrasound on liver cancer.

AIM To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in the treatment of patients with liver cancer. METHODS HIFU treatment was performed in 100 patients with liver cancer under general anesthesia and by a targeted ultrasound. Evaluation of efficacy was made on the basis of clinical symptoms, liver function tests, AFP, MRI or CT before and after the treatment. RESULTS After HIFU treatment, clinical symptoms were relieved in 86.6%(71/82) of patients. The ascites disappeared in 6 patients. ALT (95+/-44) U/L and AST (114+/-58) U/L before HIFU treatment were reduced to normal in 83.3%(30/36) and 72.9%(35/48) patients, respectively, after the treatment. AFP was lowered by more than 50% in 65.3%(32/49) patients. After HIFU treatment, MRI or CT findings indicated coagulation necrosis and blood supply reduction or disappearance of tumor in the target region. CONCLUSION HIFU can efficiently treat the patients with liver cancer. It will offer a significant noninvasive therapy for local treatment of liver tumor.

[1]  D. Cranston,et al.  High intensity focused ultrasound: surgery of the future? , 2003, The British journal of radiology.

[2]  L A Crum,et al.  Use of overpressure to assess the role of bubbles in focused ultrasound lesion shape in vitro. , 2001, Ultrasound in medicine & biology.

[3]  Wen-zhi Chen,et al.  Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound. , 2001, Ultrasound in medicine & biology.

[4]  W J FRY,et al.  Fundamental neurological research and human neurosurgery using intense ultrasound. , 1960, IRE transactions on medical electronics.

[5]  J. Anderson,et al.  High-intensity focused ultrasound ablation of rabbit kidney tumors. , 1996, Journal of endourology.

[6]  L A Crum,et al.  Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging. , 2001, Ultrasound in medicine & biology.

[7]  G. Haar,et al.  High Intensity Focused Ultrasound for the Treatment of Tumors , 2001, Echocardiography.

[8]  Destruction de parenchyme hépatique par ultrasons focalisés , 2003 .

[9]  J. Schalken,et al.  Influence of high-intensity focused ultrasound on the development of metastases. , 1997, European urology.

[10]  S. L. Griffith,et al.  Extracorporeal Liver Ablation Using Sonography-Guided High-Intensity Focused Ultrasound , 1992, Investigative radiology.

[11]  K. Kopecky,et al.  Sonographic and computed tomography characteristics of liver ablation lesions induced by high-intensity focussed ultrasound , 1993 .

[12]  Gail ter Haar,et al.  High intensity ultrasound. , 2001 .

[13]  K. Hynynen,et al.  The effects of tissue heterogeneities and large blood vessels on the thermal exposure induced by short high-power ultrasound pulses. , 1992, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[14]  T. Ponchon,et al.  Hepatic lesions in the rabbit induced by acoustic cavitation. , 1991, Gastroenterology.

[15]  T. Ponchon,et al.  Extracorporeal ablation of liver tissue by high-intensity focused ultrasound. , 1993, Oncology.

[16]  F. Fry,et al.  High-intensity focused ultrasound in the treatment of experimental liver cancer. , 1991, Archives of surgery.

[17]  Wen-zhi Chen,et al.  [High intensity focused ultrasound therapy combined with transcatheter arterial chemoembolization for advanced hepatocellular carcinoma]. , 2003, Zhonghua zhong liu za zhi [Chinese journal of oncology].

[18]  S. Vaezy,et al.  Tissue ablation using high-intensity focused ultrasound in the fetal sheep model: potential for fetal treatment. , 2003, American journal of obstetrics and gynecology.

[19]  F. Wu,et al.  [Pathological study of extracorporeally ablated hepatocellular carcinoma with high-intensity focused ultrasound]. , 2001, Zhonghua zhong liu za zhi [Chinese journal of oncology].

[20]  T. Krouskop,et al.  Elastographic characterization of HIFU-induced lesions in canine livers. , 1999, Ultrasound in medicine & biology.

[21]  Kazuaki Sasaki,et al.  Functional and histological changes in rat femoral arteries by HIFU exposure. , 2003, Ultrasound in medicine & biology.

[22]  T. Ponchon,et al.  Characterization of extracorporeal ablation of normal and tumor-bearing liver tissue by high intensity focused ultrasound. , 1993, Ultrasound in medicine & biology.

[23]  Faqi Li,et al.  Study of a "biological focal region" of high-intensity focused ultrasound. , 2003, Ultrasound in medicine & biology.

[24]  Wen-zhi Chen,et al.  Tumor vessel destruction resulting from high-intensity focused ultrasound in patients with solid malignancies. , 2002, Ultrasound in medicine & biology.

[25]  Z. Wang,et al.  Targeted damage effects of high intensity focused ultrasound (HIFU) on liver tissues of Guizhou Province miniswine. , 1997, Ultrasonics sonochemistry.

[26]  K. Kopecky,et al.  Liver cancer ablation with extracorporeal high-intensity focused ultrasound. , 1993, European urology.

[27]  Zhao-You Tang,et al.  High-intensity focused ultrasound in the treatment of experimental liver tumour , 2005, Journal of Cancer Research and Clinical Oncology.