Subcortical degeneration in Alzheimer's disease

Although Alzheimer's disease is generally considered a degenerative disease that primarily affects the cerebral cortex, subcortical structures such as the substantia innominata and certain brainstem nuclei may be involved. In 28 patients with progressive dementia and pathologically confirmed Alzheimer's disease, we found senile (neuritic) plaques and neurofibrillary tangles in the thalamus in 25 patients, in the hypothalamus in 22, and in the mamillary body in 17. The severity of these lesions seemed to be greater in those with presenile onset of dementia, but was not related to the duration of dementia. Alzheimer's disease is a much more diffuse disorder than is usually appreciated.

[1]  R. Terry,et al.  Senile dementia of the Alzheimer type , 1983, Annals of neurology.

[2]  M N Rossor,et al.  A post-mortem study of the cholinergic and GABA systems in senile dementia. , 1982, Brain : a journal of neurology.

[3]  W. Bondareff,et al.  Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia , 1982, Neurology.

[4]  J. Coyle,et al.  Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis , 1981, Annals of neurology.

[5]  D. J. Marshall,et al.  HYPOTHALAMUS AND DEMENTIA , 1981, The Lancet.

[6]  L. Iversen,et al.  ARGININE VASOPRESSIN AND CHOLINE ACETYLTRANSFERASE IN BRAINS OF PATIENTS WITH ALZHEIMER TYPE SENILE DEMENTIA , 1980, The Lancet.

[7]  S. M. Sumi,et al.  Presenile Alzheimer disease , 1980, Neurology.

[8]  W. Meier-Ruge,et al.  ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA? , 1979, The Lancet.

[9]  Robert H. Perry,et al.  Neurotransmitter enzyme abnormalities in senile dementia Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue , 1977, Journal of the Neurological Sciences.

[10]  D. Bowen,et al.  NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE , 1977, The Lancet.

[11]  G. Blessed,et al.  NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIA , 1977, The Lancet.

[12]  P. Davies,et al.  SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE , 1976, The Lancet.

[13]  M. Victor,et al.  The amnesic syndrome and its anatomical basis. , 1969, Canadian Medical Association journal.

[14]  J. Brierley,et al.  Observations on the pathology of insidious dementia following head injury. , 1959, The Journal of mental science.

[15]  R. Waggoner,et al.  FAMILIAL ORGANIC PSYCHOSIS (ALZHEIMER'S TYPE) , 1934 .