How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case

[1]  J. Gibrat,et al.  Modeling of mammalian olfactory receptors and docking of odorants , 2012, Biophysical Reviews.

[2]  Jean-François Gibrat,et al.  Automatic modeling of mammalian olfactory receptors and docking of odorants. , 2012, Protein engineering, design & selection : PEDS.

[3]  Ravinder Abrol,et al.  Bihelix: Towards de novo structure prediction of an ensemble of G‐protein coupled receptor conformations , 2012, Proteins.

[4]  K. Gerwert,et al.  Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling. , 2012, Angewandte Chemie.

[5]  W. Goddard,et al.  Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins. , 2011, Methods.

[6]  Albert C. Pan,et al.  Activation mechanism of the β2-adrenergic receptor , 2011, Proceedings of the National Academy of Sciences.

[7]  Kunhong Xiao,et al.  Multiple ligand-specific conformations of the β2-adrenergic receptor. , 2011, Nature chemical biology.

[8]  Torsten Schwede,et al.  The mouse eugenol odorant receptor: structural and functional plasticity of a broadly tuned odorant binding pocket. , 2011, Biochemistry.

[9]  Roman G. Efremov,et al.  PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes , 2009, Bioinform..

[10]  C. Sell Odor cannot be predicted by molecular shape. , 2009, Chemical senses.

[11]  Elisabeth Guichard,et al.  Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor. , 2008, Chemical senses.

[12]  M. Spehr,et al.  Odorant–Receptor Interactions and Odor Percept: A Chemical Perspective , 2008, Chemistry & biodiversity.

[13]  Serge Antonczak,et al.  Binding free energy prediction in strongly hydrophobic biomolecular systems. , 2007, Physical chemistry chemical physics : PCCP.

[14]  L. Vosshall,et al.  Genetic variation in a human odorant receptor alters odour perception , 2007, Nature.

[15]  Dietmar Krautwurst,et al.  Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. , 2007, Journal of structural biology.

[16]  S. Antonczak,et al.  Mechanistic events underlying odorant binding protein chemoreception , 2007, Proteins.

[17]  H. Hatt,et al.  Prediction of perception: probing the hOR17-4 olfactory receptor model with silicon analogues of bourgeonal and lilial. , 2007, Angewandte Chemie.

[18]  M. Scippo,et al.  Solubilisation and binding characteristics of a recombinant beta2-adrenergic receptor expressed in the membrane of Escherichia coli for the multianalyte detection of beta-agonists and antagonists residues in food-producing animals. , 2007, Analytica chimica acta.

[19]  Edgar Jacoby,et al.  Molecular lipophilicity in protein modeling and drug design. , 2007, Current medicinal chemistry.

[20]  C. Sell,et al.  On the unpredictability of odor. , 2006, Angewandte Chemie.

[21]  Chiquito J Crasto,et al.  Structural activation pathways from dynamic olfactory receptor-odorant interactions. , 2005, Chemical senses.

[22]  Patrick Etiévant,et al.  Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system. , 2005, Chemical senses.

[23]  Nagarajan Vaidehi,et al.  Test of the Binding Threshold Hypothesis for olfactory receptors: Explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912‐93 , 2005, Protein science : a publication of the Protein Society.

[24]  Makiko Suwa,et al.  Structural Basis for a Broad But Selective Ligand Spectrum of a Mouse Olfactory Receptor: Mapping the Odorant-Binding Site , 2005, The Journal of Neuroscience.

[25]  Nagarajan Vaidehi,et al.  Predicted 3-D structures for mouse I7 and rat I7 olfactory receptors and comparison of predicted odor recognition profiles with experiment. , 2004, Chemical senses.

[26]  Doron Lancet,et al.  Prediction of the odorant binding site of olfactory receptor proteins by human–mouse comparisons , 2004, Protein science : a publication of the Protein Society.

[27]  Peter L. Freddolino,et al.  Prediction of structure and function of G protein-coupled receptors , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R. Araneda,et al.  The molecular receptive range of an odorant receptor , 2000, Nature Neuroscience.

[29]  P. Kollman,et al.  Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models. , 2000, Accounts of chemical research.

[30]  G M Shepherd,et al.  Molecular mechanisms underlying differential odor responses of a mouse olfactory receptor. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[31]  C. Cambillau,et al.  Complexes of porcine odorant binding protein with odorant molecules belonging to different chemical classes. , 2000, Journal of molecular biology.

[32]  M. S. Singer,et al.  Analysis of the molecular basis for octanal interactions in the expressed rat 17 olfactory receptor. , 2000, Chemical senses.

[33]  L. Buck,et al.  Combinatorial Receptor Codes for Odors , 1999, Cell.

[34]  H. Surburg,et al.  Common Fragrance and Flavor Materials: Preparation, Properties and Uses , 1997 .

[35]  Gordon M. Shepherd,et al.  Molecular modeling of ligand-receptor interactions in the OR5 olfactory receptor. , 1994, Neuroreport.

[36]  R. Axel,et al.  A novel multigene family may encode odorant receptors: A molecular basis for odor recognition , 1991, Cell.

[37]  R. Schultes Common Fragrance and Flavor Materials: Preparation, Properties and Uses , 1987, Economic Botany.

[38]  Loïc Briand,et al.  Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism. , 2005, Chemical senses.