Three-dimensional tumor localization in thick tissue with the use of diffuse photon-density waves.

A new approach to three-dimensional tumor localization in turbid media with the use of measurements in a single plane is presented. Optical diffuse photon-density waves are used to probe the turbid medium. Relative amplitudes and phases are measured in the detection plane. Lateral localization is accomplished in the detection plane. With a Fourier optics approach, the scattered wave is reconstructed throughout the volume to provide depth localization. Computer-simulation results that validate this technique are presented. Applications of this technique to multiple tumors and to optical mammography are discussed.

[1]  R R Alfano,et al.  Time-Resolved Imaging of Translucent Droplets in Highly Scattering Turbid Media , 1994, Science.

[2]  J. Fujimoto,et al.  Optical coherence microscopy in scattering media. , 1994, Optics letters.

[3]  B. A. Wechsler,et al.  Depth-resolved holographic imaging through scattering media by photorefraction. , 1995, Optics letters.

[4]  D. Boas,et al.  Experimental images of heterogeneous turbid media by frequency-domain diffusing-photon tomography. , 1995, Optics letters.

[5]  E N Leith,et al.  Imaging absorbing structures within thick diffusing media. , 1990, Applied optics.

[6]  G. Müller,et al.  Medical Optical Tomography: Functional Imaging and Monitoring , 1993 .

[7]  E Gratton,et al.  Propagation of photon-density waves in strongly scattering media containing an absorbing semi-infinite plane bounded by a straight edge. , 1993, Journal of the Optical Society of America. A, Optics and image science.

[8]  B. Chance,et al.  Spectroscopy and Imaging with Diffusing Light , 1995 .

[9]  C S Chui,et al.  Generation of arbitrary intensity profiles by combining the scanning beam with dynamic multileaf collimation. , 1996, Medical physics.

[10]  K.,et al.  Frequency-domain optical mammography: edge effect corrections. , 1996, Medical physics.

[11]  R R Alfano,et al.  Ultrafast time-gated imaging in thick tissues: a step toward optical mammography. , 1993, Optics letters.

[12]  J M Schmitt,et al.  Spatial localization of absorbing bodies by interfering diffusive photon-density waves. , 1993, Applied optics.

[13]  A J Devaney,et al.  Reconstructive tomography with diffracting wavefields , 1986 .

[14]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[15]  J. Schmitt,et al.  Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering. , 1994, Physics in medicine and biology.

[16]  A G Yodh,et al.  Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media: analytic solution and applications. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[17]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[18]  J M Schmitt,et al.  Interference of diffusive light waves. , 1992, Journal of the Optical Society of America. A, Optics and image science.

[19]  E Gratton,et al.  Frequency-domain method for measuring spectral properties in multiple-scattering media: methemoglobin absorption spectrum in a tissuelike phantom. , 1995, Applied optics.

[20]  M S Patterson,et al.  Optical properties of normal and diseased human breast tissues in the visible and near infrared. , 1990, Physics in medicine and biology.