Nanoparticle pollution and associated increasing potential risks on environment and human health: a case study of China

The aims of this study are (1) to discuss the mechanism of nanoparticle lifecycle and estimate the impacts of its associated pollution on environment and human health; and (2) to provide recommendation to policy makers on how to leverage nanopollution and human health along with the rapid development of economics in China. Manufactured nanoparticles (MNPs) could either directly or indirectly impair human health and the environment. Exposures to MNP include many ways, such as via inhalation, ingestion, direct contact, or the use of consumer products over the lifecycle of the product. In China, the number of people exposed to MNP has been increasing year by year. To better provide medical care to people exposed to MNP, the Chinese government has established many disease control and prevention centers over China. However, the existing facilities and resources for controlling MNP are still not enough considering the number of people impacted by MNP and the number of ordinary workers in the MNP related industry applying for their occupational identification through the Center for Disease Control and Prevention. China should assess the apparent risk environment and human health being exposed to MNP and develop action plans to reduce the possibility of direct contacts between human beings and the emerging nanomaterials. In addition, we suggest more comprehensive studies on the MNP behavior and the development of quantitative approaches to measure MNP transport, and persistence should be carried out.

[1]  Y. Song,et al.  Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma , 2009, European Respiratory Journal.

[2]  M. Hande,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in human cells. , 2009, ACS nano.

[3]  Morteza Mahmoudi,et al.  Protein-Nanoparticle Interactions , 2013 .

[4]  P. Jaques,et al.  Respiratory dose of inhaled ultrafine particles in healthy adults , 2000, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[5]  R. Burnett,et al.  Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease , 2003, Circulation.

[6]  H. T. Moriya,et al.  Chronic exposure of diesel exhaust particles induces alveolar enlargement in mice , 2011, Respiratory Research.

[7]  John K McGee,et al.  Source apportionment of particulate matter in the U.S. and associations with lung inflammatory markers. , 2008, Inhalation toxicology.

[8]  Wenhua Wang,et al.  Bioavailability, mobility, and toxicity of Cu in soils around the Dexing Cu mine in China , 2011, Environmental geochemistry and health.

[9]  Kaja Kasemets,et al.  Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[10]  Kenneth A. Dawson,et al.  Protein–Nanoparticle Interactions , 2008, Nano-Enabled Medical Applications.

[11]  H. Autrup,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549 , 2011, Archives of Toxicology.

[12]  Viroj Wiwanitkit,et al.  Effect of gold nanoparticles on spermatozoa: the first world report. , 2009, Fertility and sterility.

[13]  Eleonore Fröhlich,et al.  The role of nanoparticle size in hemocompatibility. , 2009, Toxicology.

[14]  H. Norppa,et al.  Risk assessment of engineered nanomaterials and nanotechnologies--a review. , 2010, Toxicology.

[15]  Wei Jiang,et al.  Bacterial toxicity comparison between nano- and micro-scaled oxide particles. , 2009, Environmental pollution.

[16]  Sabine Neuss,et al.  Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage. , 2009, Small.

[17]  C. Miao,et al.  A preliminary estimate of human and natural contributions to the changes in water discharge and sediment load in the Yellow River , 2011 .

[18]  E. Cummins,et al.  A Risk Assessment Framework for Assessing Metallic Nanomaterials of Environmental Concern: Aquatic Exposure and Behavior , 2011, Risk analysis : an official publication of the Society for Risk Analysis.

[19]  Zhili Zuo,et al.  PM2.5 in China: Measurements, sources, visibility and health effects, and mitigation , 2014 .

[20]  Nanna B. Hartmann,et al.  Toxicity and bioaccumulation of xenobiotic organic compounds in the presence of aqueous suspensions of aggregates of nano-C(60). , 2008, Aquatic toxicology.

[21]  Guadalupe de la Rosa,et al.  Evidence of the differential biotransformation and genotoxicity of ZnO and CeO2 nanoparticles on soybean (Glycine max) plants. , 2010, Environmental science & technology.

[22]  Joakim Pagels,et al.  Experimental determination of deposition of diesel exhaust particles in the human respiratory tract , 2012 .

[23]  S. Sorooshian,et al.  Evaluation of the PERSIANN-CDR Daily Rainfall Estimates in Capturing the Behavior of Extreme Precipitation Events over China , 2014 .

[24]  M. Cunningham,et al.  Gene–Cellular Interactions of Nanomaterials: Genotoxicity to Genomics , 2007 .

[25]  N. Miura,et al.  Cytotoxic effect and apoptosis induction by silver nanoparticles in HeLa cells. , 2009, Biochemical and biophysical research communications.

[26]  H. Wichmann.  Diesel Exhaust Particles , 2007, Inhalation toxicology.

[27]  Vicki Stone,et al.  Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments , 2009, Environmental health : a global access science source.

[28]  S. Okabe,et al.  In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells. , 2009, Environmental science & technology.

[29]  Jacques Buffle,et al.  The Key Role of Environmental Colloids/Nanoparticles for the Sustainability of Life , 2006 .

[30]  Conrad Coester,et al.  Particle and Fibre Toxicology BioMed Central Methodology , 2008 .

[31]  B. Nowack,et al.  Occurrence, behavior and effects of nanoparticles in the environment. , 2007, Environmental pollution.

[32]  M. Wiesner,et al.  Chemical stability of metallic nanoparticles: a parameter controlling their potential cellular toxicity in vitro. , 2009, Environmental pollution.

[33]  J. James,et al.  Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[34]  Alok Dhawan,et al.  Toxicity assessment of nanomaterials: methods and challenges , 2010, Analytical and bioanalytical chemistry.

[35]  Guodong Yuan,et al.  Nanoparticles in the Soil Environment , 2008 .

[36]  Deny Hartono,et al.  Autophagy and oxidative stress associated with gold nanoparticles. , 2010, Biomaterials.

[37]  H. Lindberg,et al.  Nanotechnologies, engineered nanomaterials and occupational health and safety – A review , 2010 .

[38]  Min Shao,et al.  Carbonyl emissions from heavy-duty diesel vehicle exhaust in China and the contribution to ozone formation potential. , 2014, Journal of environmental sciences.

[39]  A. Piazzalunga,et al.  High secondary aerosol contribution to particulate pollution during haze events in China , 2014, Nature.

[40]  Leonard Sweet,et al.  Nanotechnology—Life-Cycle Risk Management , 2006 .

[41]  Xiaohui Xu,et al.  Fine particulate air pollution and daily mortality in Shenyang, China. , 2011, The Science of the total environment.

[42]  Peter D Sly,et al.  Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. , 2008, The Journal of allergy and clinical immunology.

[43]  David Schneider,et al.  Cytotoxicity of metal and semiconductor nanoparticles indicated by cellular micromotility. , 2009, ACS nano.

[44]  Xuezhi Zhang,et al.  The impact of ZnO nanoparticle aggregates on the embryonic development of zebrafish (Danio rerio) , 2009, Nanotechnology.

[45]  Jun Xia,et al.  Chromium contamination accident in China: viewing environment policy of China. , 2011, Environmental science & technology.

[46]  Karluss Thomas,et al.  Research strategies for safety evaluation of nanomaterials, part VIII: International efforts to develop risk-based safety evaluations for nanomaterials. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[47]  Fadri Gottschalk,et al.  The release of engineered nanomaterials to the environment. , 2011, Journal of environmental monitoring : JEM.

[48]  M. Wiesner,et al.  Aggregation and Deposition Characteristics of Fullerene Nanoparticles in Aqueous Systems , 2005 .

[49]  Craig A. Poland,et al.  Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. , 2008, Nature nanotechnology.

[50]  M. Hande,et al.  Anti-proliferative activity of silver nanoparticles , 2009, BMC Cell Biology.

[51]  Igor Linkov,et al.  Nano Risk Governance: Current Developments and Future Perspectives , 2009 .

[52]  Karluss Thomas,et al.  Moving toward exposure and risk evaluation of nanomaterials: challenges and future directions. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[53]  Scott E McNeil,et al.  Nanotechnology for the biologist , 2005, Journal of leukocyte biology.

[54]  A. Borthwick,et al.  Recent changes of water discharge and sediment load in the Yellow River basin, China , 2010 .

[55]  Bong Hyun Chung,et al.  Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. , 2009, Toxicology and applied pharmacology.

[56]  Thierry Meyer,et al.  Management of nanomaterials safety in research environment , 2010, Particle and Fibre Toxicology.

[57]  Tung-Sheng Shih,et al.  The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. , 2008, Toxicology letters.

[58]  C. Soto,et al.  Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice. , 2010, Biochemical and biophysical research communications.

[59]  Leonel Hernández-Mena,et al.  Enrichment Factor and Profiles of Elemental Composition of PM 2.5 in the City of Guadalajara, Mexico , 2011, Bulletin of environmental contamination and toxicology.

[60]  Zhuanxi Luo,et al.  Metallic nanoparticle production and consumption in China between 2000 and 2010 and associative aquatic environmental risk assessment , 2013, Journal of Nanoparticle Research.