论文信息 - MODIFICATION OF SUBSTITUENT EFFECT BY CYCLODEXTRIN COMPLEXATION IN ALKALINE HYDROLYSIS OF 7-SUBSTITUTED COUMARINS

MODIFICATION OF SUBSTITUENT EFFECT BY CYCLODEXTRIN COMPLEXATION IN ALKALINE HYDROLYSIS OF 7-SUBSTITUTED COUMARINS

The substituent effect in the alkaline hydrolysis of 7-substituted coumarins in the absence and presence of cyclodextrin (CyD) was analyzed by a modified Hammett equation (1). It was shown that the transmission route of the substituent effect to reaction site was altered by the inclusion of coumarin molecule within hydrophobic CyD cavity.

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