The purpose of this study was to analyze the effect of implementing ISO 9001: 2015 quality management system, ISO 14001: 2015 environmental management system, ISO 45001: 2018 occupational safety management system and ISO 22000 food safety management system on manufacturing manufacturing company performance. The method used in this study is a quantitative method and data processed by structural equation modeling (SEM) using SmartPLS 3.0 software. Data collection by distributing questionnaires online to 220 managers in manufacturing companies in Indonesia who have implemented ISO 9001, ISO 14001, ISO 45001 and ISO 22000. Questionnaire forms were distributed online and the sampling method using snowball sampling. The results of this study are the application of ISO 9001: 2015 quality management system has a positive and significant relationship to manufacturing performance, the application of ISO 14001: 2015 environmental management system has a positive and significant relationship to manufacturing performance, the application of work safety management system ISO 45001: 2018 has a relationship positive and significant impact on manufacturing performance and the application of food safety management systems ISO 22000: 2018 has a positive and significant relationship to manufacturing performance. This research novelty is the first research in Indonesia to analyze the latest management systems ISO 9001: 2015, ISO 14001: 2015, ISO 45001: 2018 and ISO 22000: 2018