The effect of a 6-month walking program on biochemical parameters in sedentary adults with type 2 diabetes mellitus

ABSTRACT This study assessed the effect of a 6-month walking program on biochemical parameters in patients with type-2 diabetes mellitus. A group of 40 sedentary patients with type-2 diabetes volunteered to participate in this study. Plasma glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase, urea, creatinine, uric acid, C-reactive protein (CRP), and erythrocyte sedimentation rate were measured. Differences in outcome measures between pre- and post-intervention were assessed using paired t-test or Wilcoxon signed-rank test, with effect sizes interpreted separately for normally (µ2: small 0.01–0.06, moderate 0.061–0.14, and large >0.14) and non-normally distributed data (r: small = 0.1–0.3, moderate = 0.3–0.5, and large >0.5). Significant (p < 0.001) large decrease between the initial and final measurements was observed for glucose (r = 0.62), total cholesterol (µ2 = 0.88), triglycerides (r = 0.62), LDL (r = 0.61), AST (µ2 = 0.82), ALT (µ2 = 0.79), gamma-glutamyl transferase (µ2 = 0.79), urea (µ2 = 0.92), creatinine (r = 0.62), uric acid (r = 0.62), CRP (µ2 = 0.80), and erythrocyte sedimentation rate (µ2 = 0.58). On the other hand, significant (p < 0.001) large increase between the initial and final measurements was observed for HDL (r = 0.62). Supervised 6-month aerobic walking program is an effective strategy in (1) reducing hyperglycemia; (2) increasing HDL and reducing LDL, and triglycerides; (3) reducing plasma biomarkers of liver dysfunction, kidney dysfunction, and inflammation in type-2 diabetic patients.