miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes

[1]  M. Boldin,et al.  microRNA‐146a controls age‐related bone loss , 2020, Aging cell.

[2]  N. LeBrasseur,et al.  Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span. , 2020, Annual review of pharmacology and toxicology.

[3]  W. Chao,et al.  Extracellular miR-146a-5p Induces Cardiac Innate Immune Response and Cardiomyocyte Dysfunction , 2020, ImmunoHorizons.

[4]  I. Bellantuono,et al.  Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies , 2020, Cancers.

[5]  S. Khosla,et al.  Reducing Senescent Cell Burden in Aging and Disease. , 2020, Trends in molecular medicine.

[6]  M. Jensen,et al.  Targeting senescent cells alleviates obesity‐induced metabolic dysfunction , 2019, Aging cell.

[7]  N. LeBrasseur,et al.  Cellular senescence: Implications for metabolic disease , 2017, Molecular and Cellular Endocrinology.

[8]  Yan Tang,et al.  MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1 , 2017, Scientific Reports.

[9]  K. Lamperska,et al.  Biological role of long non-coding RNA in head and neck cancers. , 2017, Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology.

[10]  M. Nakazato,et al.  International Journal of Molecular Sciences the Impacts of Cellular Senescence in Elderly Pneumonia and in Age-related Lung Diseases That Increase the Risk of Respiratory Infections , 2022 .

[11]  M. Masternak,et al.  MicroRNAs and the Metabolic Hallmarks of Aging , 2017, Molecular and Cellular Endocrinology.

[12]  P. Golusiński,et al.  Changes of Ovarian microRNA Profile in Long-Living Ames Dwarf Mice during Aging , 2017, PloS one.

[13]  C. Cogoni,et al.  MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions , 2016, International journal of molecular sciences.

[14]  Kang Xu,et al.  MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice , 2016, PLoS genetics.

[15]  R. Westendorp,et al.  Secreted microvesicular miR‐31 inhibits osteogenic differentiation of mesenchymal stem cells , 2016, Aging cell.

[16]  P. Fischer-Posovszky,et al.  miR-146a-mediated suppression of the inflammatory response in human adipocytes , 2015, Scientific Reports.

[17]  M. Masternak,et al.  Circulating microRNA signature of genotype‐by‐age interactions in the long‐lived Ames dwarf mouse , 2015, Aging cell.

[18]  N. LeBrasseur,et al.  Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity , 2015, Diabetes.

[19]  Kenneth K. Wu,et al.  High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy , 2015, PloS one.

[20]  N. LeBrasseur,et al.  The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs , 2015, Aging cell.

[21]  A. Bartke,et al.  Thyroxine modifies the effects of growth hormone in Ames dwarf mice , 2015, Aging.

[22]  Myung‐Sook Choi,et al.  Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease , 2014, International journal of molecular sciences.

[23]  A. Bartke,et al.  The contribution of visceral fat to improved insulin signaling in Ames dwarf mice , 2014, Aging cell.

[24]  Piotr J. Balwierz,et al.  Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity , 2012, Diabetes.

[25]  J. Mendell,et al.  MicroRNAs in Stress Signaling and Human Disease , 2012, Cell.

[26]  L. Hughes,et al.  Metabolic effects of intra‐abdominal fat in GHRKO mice , 2012, Aging cell.

[27]  F. Slack,et al.  MicroRNAs and their roles in aging , 2012, Journal of Cell Science.

[28]  N. LeBrasseur,et al.  Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.

[29]  G. Calin,et al.  MicroRNAs in body fluids—the mix of hormones and biomarkers , 2011, Nature Reviews Clinical Oncology.

[30]  P. Linsley,et al.  miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice , 2011, The Journal of experimental medicine.

[31]  Ryan M. O’Connell,et al.  NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies , 2011, Proceedings of the National Academy of Sciences.

[32]  Zachary Pincus,et al.  MicroRNAs Both Promote and Antagonize Longevity in C. elegans , 2010, Current Biology.

[33]  A. Bartke,et al.  Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  D. Peeper,et al.  The essence of senescence. , 2010, Genes & development.

[35]  David Baltimore,et al.  Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses , 2010, Cell.

[36]  J. Grillari,et al.  miR-17–92 cluster: ups and downs in cancer and aging , 2010, Biogerontology.

[37]  M. Mildner,et al.  miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging , 2010, Aging cell.

[38]  L. Hughes,et al.  Insulin sensitivity as a key mediator of growth hormone actions on longevity. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[39]  Gordon J. Lithgow,et al.  MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 , 2009, Aging.

[40]  M. Fasshauer,et al.  MicroRNA Expression in Human Omental and Subcutaneous Adipose Tissue , 2009, PloS one.

[41]  D. Baltimore,et al.  MicroRNAs and immunity: tiny players in a big field. , 2007, Immunity.

[42]  M. Stoffel,et al.  MicroRNAs: a new class of regulatory genes affecting metabolism. , 2006, Cell metabolism.

[43]  A. Scutt,et al.  Glucose-induced replicative senescence in mesenchymal stem cells. , 2006, Rejuvenation research.

[44]  N. Rajewsky,et al.  A pancreatic islet-specific microRNA regulates insulin secretion , 2004, Nature.

[45]  A. Bartke,et al.  Divergent effects of caloric restriction on gene expression in normal and long-lived mice. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[46]  A. Bartke,et al.  Could a deficiency in growth hormone signaling be beneficial to the aging brain? , 2004, Physiology & Behavior.

[47]  D. Bartel MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[48]  S. Koyasu,et al.  PI3K and negative regulation of TLR signaling. , 2003, Trends in immunology.

[49]  R. Bronson,et al.  Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[50]  Andrzej Bartke,et al.  Longevity: Extending the lifespan of long-lived mice , 2001, Nature.

[51]  J. Campisi,et al.  Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[52]  A. Bartke,et al.  Prolonged longevity of hypopituitary dwarf mice , 2001, Experimental Gerontology.

[53]  Wei Wu,et al.  Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism , 1996, Nature.

[54]  P. Golusiński,et al.  Characteristic miRNA expression signature and random forest survival analysis identify potential cancer-driving miRNAs in a broad range of head and neck squamous cell carcinoma subtypes. , 2018, Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology.

[55]  A. Bartke,et al.  Dwarf Mice and Aging. , 2018, Progress in molecular biology and translational science.

[56]  Ryan D. Morin,et al.  Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype , 2010, Nature Medicine.