Humoral immunity in Japanese quail following surgical bursectomy at various ages.

Four separate experiments were conducted to determine the effects of surgical bursectomy (BSX) at periodic intervals on subsequent antibody production in Japanese quail. At 0, 1, 3, 7, and 28 days of age, BSX resulted in graduated increments in humoral immune responsiveness. Quail BSX at 0 and 1 day of age exhibited significantly reduced primary hemagglutinin responses, as well as reduced mercaptoethanol resistant (IgG) antibody levels. The production of mercaptoethanol sensitive antibody (IgM) levels were affected to a lesser degree in BSX quail than in controls. At 7 and 28 days of age, BSX resulted in no significant effects. At 3 days of age, BSX resulted in an intermediate effect with minimal reduction in antibody levels. Secondary antibody responses were reduced to a lesser extent than the primary responses. At 0 day, BSX reduced hemagglutinin and mercaptoethanol sensitive antibody levels during the early stages of the secondary responses. At other times, however, BSX did not affect secondary antibody responses.

[1]  J. Bienenstock,et al.  Effects of bursectomy and thymectomy on ontogeny of fowl IgA, IgG, and IgM. , 1973, Journal of immunology.

[2]  M. Cooper,et al.  A two-stage model for development of antibody-producing cells. , 1972, Clinical and experimental immunology.

[3]  A. A. Benedict,et al.  Structural and antigenic relationships between avian immunoglobulins. 3. Antigenic relationships of the immunoglobulins of the chicken, pheasant and Japanese quail. , 1970, Journal of immunology.

[4]  M. Cooper,et al.  Development and Function of the Immunoglobulin-Producing System , 1969, The Journal of Immunology.

[5]  B. Arnason,et al.  Immunoglobulins after surgical bursectomy in chickens. , 1967, Journal of Immunology.

[6]  J. B. Solomon,et al.  The nature of antibodies to goat erythrocytes in the developing chicken. , 1966, Immunology.

[7]  M. Cooper,et al.  THE FUNCTIONS OF THE THYMUS SYSTEM AND THE BURSA SYSTEM IN THE CHICKEN , 1966, The Journal of experimental medicine.

[8]  N. Warner.  THE IMMUNOLOGICAL ROLE OF DIFFERENT LYMPHOID ORGANS IN THE CHICKEN. II. THE IMMUNOLOGICAL COMPETENCE OF THYMIC CELL SUSPENSIONS. , 1964, The Australian journal of experimental biology and medical science.

[9]  B. Glick.  The Effect of Surgical and Chemical Bursectomy in the White Pekin Duck , 1963 .

[10]  A. Szenberg,et al.  Immunological Function of Thymus and Bursa of Fabricius: Dissociation of Immunological Responsiveness in Fowls with a Hormonally Arrested Development of Lymphoid Tissues , 1962, Nature.

[11]  R. K. Meyer,et al.  Further studies on the role of the bursa of Fabricius in antibody production. , 1962, Journal of immunology.

[12]  A. R. Winter,et al.  The Significance of the Bursa of Fabricius in Antibody Production in Chickens 1. Age of Chickens , 1957 .

[13]  Clyde Young Kramer,et al.  Extension of multiple range tests to group means with unequal numbers of replications , 1956 .

[14]  T. Makinodan,et al.  Precipitin Production in Chickens , 1946, The Journal of Immunology.

[15]  F. G. Benedict,et al.  STUDIES ON THE PHYSIOLOGY OF REPRODUCTION IN BIRDS: XXXII. Basal Metabolism and the Temperature Factor in Brooding Ring Doves , 1933 .

[16]  C. Parkhurst,et al.  Antibody responses to xenogeneic red blood cell challenge in the Japanese quail. , 1977, Immunological communications.

[17]  B. Glick.  The bursa of Fabricius and immunoglobulin synthesis. , 1977, International review of cytology.

[18]  T. Linna,et al.  The inability of surgical bursectomy in the newly hatched period to affect antibody formation in the pigeon (Columba livia). , 1975, Immunological communications.

[19]  B. Glick.  Growth of the Bursa of Fabricius and its Relationship to the Adrenal Gland in the White Pekin Duck, White Leghorn, Outbred and Inbred New Hampshire , 1960 .

[20]  B. Glick,et al.  The Bursa of Fabricius and Antibody Production , 1956 .