Analyzing the Etiology of Benign Rolandic Epilepsy: A Multicenter Twin Collaboration

Summary:  Purpose: Benign rolandic epilepsy (BRE) is considered a genetically determined idiopathic partial epilepsy. We analyzed a large sample of twins from four international twin registers to probe the genetics of BRE. We also aim to synthesize the apparently conflicting family and twin data into a model of BRE etiology.

[1]  U. Stephani,et al.  Atypical "benign" partial epilepsy of childhood or pseudo-lennox syndrome. Part II: family study. , 2001, Neuropediatrics.

[2]  S. Berkovic,et al.  Epilepsies in twins: Genetics of the major epilepsy syndromes , 1998, Annals of neurology.

[3]  S. Blom,et al.  Benign Epilepsy of Children with Centro‐temporal EEG Foci. Prevalence and follow‐up study of 40 patients* , 1972, Epilepsia.

[4]  H. Degen,et al.  Some Genetic Aspects of Rolandic Epilepsy: Waking and Sleep EEGs in Siblings , 1990, Epilepsia.

[5]  C. Wadelius,et al.  Centrotemporal spikes in families with rolandic epilepsy , 1998, Neurology.

[6]  I. Scheffer,et al.  Is benign rolandic epilepsy genetically determined? , 2004, Annals of neurology.

[7]  Kaare Christensen,et al.  Epileptic seizures and syndromes in twins: the importance of genetic factors , 2003, Epilepsy Research.

[8]  P. Lerman.  Benign partial epilepsy with centro-temporal spikes , 1992 .

[9]  P. Lerman,et al.  [Benign childhood epilepsy with centro-temporal spikes]. , 2001, Harefuah.

[10]  P. Bray,et al.  EVIDENCE FOR A GENETIC ETIOLOGY OF TEMPORAL-CENTRAL ABNORMALITIES IN FOCAL EPILEPSY. , 1964, The New England journal of medicine.

[11]  S. Blom,et al.  Benign Epilepsy of Childhood with Centrotemporal EEG Foci: A Genetic Study , 1975, Epilepsia.

[12]  O. Brouwer,et al.  The course of benign partial epilepsy of childhood with centrotemporal spikes , 1997, Neurology.

[13]  P. Loiseau,et al.  Hereditary Factors in Partial Epilepsy , 1969, Epilepsia.

[14]  T. Beaty,et al.  Can familial aggregation of disease be explained by familial aggregation of environmental risk factors? , 1988, American journal of epidemiology.

[15]  H. Doose.  Genetic EEG traits in the pathogenesis of the epilepsies , 1997 .

[16]  J. Kaprio,et al.  Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. , 2000, The New England journal of medicine.

[17]  N. Risch.  Linkage strategies for genetically complex traits. I. Multilocus models. , 1990, American journal of human genetics.

[18]  H. Doose.  Symptomatology in children with focal sharp waves of genetic origin , 1989, European Journal of Pediatrics.

[19]  C. Lombroso.  Sylvian seizures and midtemporal spike foci in children. , 1967, Archives of neurology.

[20]  H Doose,et al.  Children with Focal Sharp Waves: Clinical and Genetic Aspects , 1997, Epilepsia.

[21]  L. Forsgren,et al.  A community‐based prospective incidence study of epileptic seizures in children , 1993, Acta paediatrica.

[22]  O Eeg-Olofsson,et al.  The Development of the Electroencephalogram in Normal Children from the Age of 1 Through 15 Years – Paroxysmal activity , 1971, Neuropadiatrie.

[23]  U. Stephani.  Typical semiology of benign childhood epilepsy with centrotemporal spikes (BCECTS). , 2001, Epileptic disorders : international epilepsy journal with videotape.

[24]  J. Carlin,et al.  Familial aggregation of a disease consequent upon correlation between relatives in a risk factor measured on a continuous scale. , 1992, American journal of epidemiology.

[25]  O. Eeg‐Olofsson,et al.  HLA and Epilepsy: An Investigation of Different Types of Epilepsy in Children and Their Families , 1982, Epilepsia.

[26]  P. Lerman,et al.  Focal Epileptic EEG Discharges in Children Not Suffering from Clinical Epilepsy: Etiology, Clinical Significance, and Management , 1981, Epilepsia.

[27]  R. Burdon.  Genes and the environment , 1999 .

[28]  I. Scheffer,et al.  Autosomal dominant rolandic epilepsy and speech dyspraxia: A new syndrome with anticipation , 1995, Annals of neurology.

[29]  S. Blom,et al.  Benign Epilepsy of Children with Centrotemporal EEG Foci. A Study of Incidence Rate in Outpatient Care , 1975, Epilepsia.

[30]  W. Nance,et al.  The occurrence of epilepsy and febrile seizures in Virginian and Norwegian twins , 1991, Neurology.

[31]  P. Bray,et al.  The relation of focal to diffuse epileptiform EEG dischares in genetic epilepsy. , 1965, Archives of neurology.

[32]  N. Spector.  Cancer, genes, and the environment. , 2000, The New England journal of medicine.

[33]  P. Bray,et al.  HEREDITARY CHARACTERISTICS OF FAMILIAL TEMPORAL-CENTRAL FOCAL EPILEPSY. , 1965, Pediatrics.

[34]  J. Pellock,et al.  Status Epilepticus in a Population‐based Virginia Twin Sample , 2004, Epilepsia.

[35]  J. Edwards.  The genetic basis of common disease , 1963 .