Sensitive Contrast-Enhanced Magnetic Resonance Imaging of Orthotopic and Metastatic Hepatic Tumors by Ultralow Doses of Zinc Ferrite Octapods

Contrast ability of magnetic nanoparticles (MNPs) is critical for the sensitive and accurate diagnosis of cancer with magnetic resonance imaging (MRI). However, the low sensitivity of current contrast agents (CAs) remains a major limitation to meet clinical needs. Shape and composition engineering are two important means for improving the contrast ability of MNPs. Herein, we report a facile method incorporating both approaches to manufacture zinc ferrite octapods with a large effective radius and various Zn doping ratios. The saturated magnetizations and T2 relaxivities of these engineered octapods both show an interesting trend with ascending zinc doping level. Particularly, the r2 value of ZnxFe3–xO4 (x = 0.44) octapods at 7.0 T is 989.1 mM–1s–1, and the highest T2 relaxivity ever reported, which is 10.2 times higher than the commercial sample, Feraheme. With the aid of this octapod sample, contrast-enhanced MRI (CE-MRI) for detecting orthotopic and metastatic hepatic tumors could be accomplished even a...

[1]  Jinhao Gao,et al.  The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles. , 2018, ACS nano.

[2]  G. Angelovski.  Heading toward Macromolecular and Nanosized Bioresponsive MRI Probes for Successful Functional Imaging. , 2017, Accounts of chemical research.

[3]  Chengjie Sun,et al.  Correction to “Composition Tunable Manganese Ferrite Nanoparticles for Optimized T2 Contrast Ability” , 2017, Chemistry of Materials.

[4]  Shouheng Sun,et al.  Organic Phase Syntheses of Magnetic Nanoparticles and Their Applications. , 2016, Chemical reviews.

[5]  Joseph J. Richardson,et al.  Nanoengineered Templated Polymer Particles: Navigating the Biological Realm. , 2016, Accounts of chemical research.

[6]  Lijiao Yang,et al.  Correction to Cation Exchange of Anisotropic-Shaped Magnetite Nanoparticles Generates High-Relaxivity Contrast Agents for Liver Tumor Imaging , 2016, Chemistry of Materials.

[7]  P. Guardia,et al.  CoxFe3–xO4 Nanocubes for Theranostic Applications: Effect of Cobalt Content and Particle Size , 2016 .

[8]  Mauro Ferrari,et al.  Principles of nanoparticle design for overcoming biological barriers to drug delivery , 2015, Nature Biotechnology.

[9]  J. Cheon,et al.  Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy. , 2015, Chemical reviews.

[10]  Chengjie Sun,et al.  Anisotropic Shaped Iron Oxide Nanostructures: Controlled Synthesis and Proton Relaxation Shortening Effects , 2015 .

[11]  D. Svergun,et al.  Viruslike Nanoparticles with Maghemite Cores Allow for Enhanced MRI Contrast Agents , 2015 .

[12]  Yunhui Huang,et al.  MOF‐Derived Porous ZnO/ZnFe2O4/C Octahedra with Hollow Interiors for High‐Rate Lithium‐Ion Batteries , 2014, Advanced materials.

[13]  Xiaoyuan Chen,et al.  Interplay between longitudinal and transverse contrasts in Fe3O4 nanoplates with (111) exposed surfaces. , 2014, ACS nano.

[14]  Leone Spiccia,et al.  Zwitterionic-coated "stealth" nanoparticles for biomedical applications: recent advances in countering biomolecular corona formation and uptake by the mononuclear phagocyte system. , 2014, Small.

[15]  Xin Cai,et al.  Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution , 2014, ACS nano.

[16]  E. Aboagye,et al.  Magnetic nanoparticles as contrast agents in the diagnosis and treatment of cancer. , 2013, Chemical Society reviews.

[17]  Xiaoyuan Chen,et al.  Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging , 2013, Nature Communications.

[18]  H. Lei,et al.  Ultrasmall Manganese Ferrite Nanoparticles as Positive Contrast Agent for Magnetic Resonance Imaging , 2013, Advanced healthcare materials.

[19]  Vu Ngoc Phan,et al.  A Highly Crystalline Manganese‐Doped Iron Oxide Nanocontainer with Predesigned Void Volume and Shape for Theranostic Applications , 2013, Advanced materials.

[20]  Shouheng Sun,et al.  Cobalt‐Substituted Magnetite Nanoparticles and Their Assembly into Ferrimagnetic Nanoparticle Arrays , 2013, Advanced materials.

[21]  Gang Liu,et al.  A Synergistically Enhanced T1–T2 Dual‐Modal Contrast Agent , 2012, Advanced materials.

[22]  Patrick Couvreur,et al.  Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. , 2012, Chemical reviews.

[23]  Kimberly A Kelly,et al.  M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer. , 2012, Nature nanotechnology.

[24]  Warren C W Chan,et al.  The effect of nanoparticle size, shape, and surface chemistry on biological systems. , 2012, Annual review of biomedical engineering.

[25]  Olivier Sandre,et al.  A Universal Scaling Law to Predict the Efficiency of Magnetic Nanoparticles as MRI T2‐Contrast Agents , 2012, Advanced healthcare materials.

[26]  B. Tomanek,et al.  Cation Exchange: A Facile Method To Make NaYF4:Yb,Tm-NaGdF4 Core–Shell Nanoparticles with a Thin, Tunable, and Uniform Shell , 2012 .

[27]  Hauke Kloust,et al.  Relaxivity optimization of a PEGylated iron-oxide-based negative magnetic resonance contrast agent for T₂-weighted spin-echo imaging. , 2012, ACS nano.

[28]  Xiaolian Sun,et al.  Monodisperse magnetic nanoparticles for theranostic applications. , 2011, Accounts of chemical research.

[29]  F. Gendron,et al.  Long term in vivo biotransformation of iron oxide nanoparticles. , 2011, Biomaterials.

[30]  Kit S Lam,et al.  The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. , 2011, Biomaterials.

[31]  Gang Bao,et al.  Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity. , 2010, Nano letters.

[32]  Zhen Cheng,et al.  Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles. , 2010, ACS nano.

[33]  Mauro Ferrari,et al.  Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast , 2010, Nature nanotechnology.

[34]  Ambika Bumb,et al.  Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics. , 2010, Chemical reviews.

[35]  Zhen Cheng,et al.  Ultrasmall near-infrared non-cadmium quantum dots for in vivo tumor imaging. , 2010, Small.

[36]  Oliver T. Bruns,et al.  A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles. , 2009, Nano letters.

[37]  Bing Xu,et al.  Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. , 2009, Accounts of chemical research.

[38]  Hua Ai,et al.  Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging. , 2009, Biomaterials.

[39]  Jinwoo Cheon,et al.  Critical enhancements of MRI contrast and hyperthermic effects by dopant-controlled magnetic nanoparticles. , 2009, Angewandte Chemie.

[40]  Wolfgang Schima,et al.  Clinical value of MRI liver-specific contrast agents: a tailored examination for a confident non-invasive diagnosis of focal liver lesions , 2009, European Radiology.

[41]  P. Choyke,et al.  Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. , 2008, Nanomedicine.

[42]  Lizhi Zhang,et al.  Generalized Preparation of Porous Nanocrystalline ZnFe2O4 Superstructures from Zinc Ferrioxalate Precursor and Its Superparamagnetic Property , 2008 .

[43]  J. Cheon,et al.  Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. , 2008, Accounts of chemical research.

[44]  T. Yamashita,et al.  Analysis of XPS spectra of Fe2+ and Fe3+ ions in oxide materials , 2008 .

[45]  D. Leslie-Pelecky,et al.  Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. , 2008, Molecular pharmaceutics.

[46]  Philippe Robert,et al.  Recent advances in iron oxide nanocrystal technology for medical imaging. , 2006, Advanced drug delivery reviews.

[47]  Wei Li,et al.  First‐pass contrast‐enhanced magnetic resonance angiography in humans using ferumoxytol, a novel ultrasmall superparamagnetic iron oxide (USPIO)‐based blood pool agent , 2005, Journal of magnetic resonance imaging : JMRI.

[48]  Robert D Cardiff,et al.  Developmental Context Determines Latency of MYC-Induced Tumorigenesis , 2004, PLoS biology.

[49]  S. Kumano,et al.  Using superparamagnetic iron oxide-enhanced MRI to differentiate metastatic hepatic tumors and nonsolid benign lesions. , 2003, AJR. American journal of roentgenology.

[50]  R. Brooks,et al.  On T2‐shortening by strongly magnetized spheres: A partial refocusing model , 2002, Magnetic resonance in medicine.

[51]  I. Lucet,et al.  Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution. , 1996, Journal of microencapsulation.

[52]  Jinwoo Cheon,et al.  Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging , 2007, Nature Medicine.

[53]  Tsutomu Araki,et al.  SPIO-MRI in the detection of hepatocellular carcinoma , 2000, Journal of Gastroenterology.

[54]  K. Welinder,et al.  Proton-Enhanced Relaxation in Low-Symmetry Paramagnetic Complexes (S = 1): Beyond the Solomon--Bloembergen and Morgan Theory. 1. The Smoluchowsky Distortion Model of the ZFS Interaction. , 1991 .