Self-quenched ferrocenyl diketopyrrolopyrrole organic nanoparticles with amplifying photothermal effect for cancer therapy† †Electronic supplementary information (ESI) available: Experimental methods and additional figures. See DOI: 10.1039/c7sc03351f Click here for additional data file.

A NIR D–A–D structure of a ferrocene flanked diketopyrrolopyrrole derivative with a tetracyanobutadiene unit is synthesized for photoacoustic imaging-guided amplifying photothermal therapy.

[1]  Yuanyi Zheng,et al.  A Versatile Nanotheranostic Agent for Efficient Dual‐Mode Imaging Guided Synergistic Chemo‐Thermal Tumor Therapy , 2015 .

[2]  D. Ng,et al.  A disulfide-linked conjugate of ferrocenyl chalcone and silicon(IV) phthalocyanine as an activatable photosensitiser. , 2013, Chemical communications.

[3]  Dan Yang,et al.  CuS-Pt(iv)-PEG-FA nanoparticles for targeted photothermal and chemotherapy. , 2016, Journal of materials chemistry. B.

[4]  J. Roncali,et al.  Structure–properties relationships in conjugated molecules based on diketopyrrolopyrrole for organic photovoltaics , 2012 .

[5]  Xiaojuan Pang,et al.  Indocyanine Green-Loaded Silver Nanoparticle@Polyaniline Core/Shell Theranostic Nanocomposites for Photoacoustic/Near-Infrared Fluorescence Imaging-Guided and Single-Light-Triggered Photothermal and Photodynamic Therapy. , 2016, ACS applied materials & interfaces.

[6]  Zhen Guo,et al.  Novel Mn3 [Co(CN)6]2@SiO2@Ag Core-Shell Nanocube: Enhanced Two-Photon Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Photothermal and Chemo-therapy. , 2015, Small.

[7]  C. Chiang,et al.  Dual‐Targeted Photopenetrative Delivery of Multiple Micelles/Hydrophobic Drugs by a Nanopea for Enhanced Tumor Therapy , 2016 .

[8]  Prashant K. Jain,et al.  Plasmonic photothermal therapy (PPTT) using gold nanoparticles , 2008, Lasers in Medical Science.

[9]  Zhenxin Wang,et al.  Fe2O3@Au core@shell nanoparticle–graphene nanocomposites as theranostic agents for bioimaging and chemo-photothermal synergistic therapy , 2015 .

[10]  Zhen Gu,et al.  In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy , 2017, Nature Biomedical Engineering.

[11]  Fan Zhang,et al.  Nanotubes-Embedded Indocyanine Green-Hyaluronic Acid Nanoparticles for Photoacoustic-Imaging-Guided Phototherapy. , 2016, ACS applied materials & interfaces.

[12]  Wei Huang,et al.  Diketopyrrolopyrrole-Triphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic/Photothermal Synergistic Tumor Therapy. , 2017, ACS nano.

[13]  Kai Yang,et al.  Carbon nanotubes for in vivo cancer nanotechnology , 2010 .

[14]  Minhuan Lan,et al.  Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer. , 2016, ACS applied materials & interfaces.

[15]  Wei Huang,et al.  Perylene‐Diimide‐Based Nanoparticles as Highly Efficient Photoacoustic Agents for Deep Brain Tumor Imaging in Living Mice , 2015, Advanced materials.

[16]  Chun‐Sing Lee,et al.  Highly stable organic fluorescent nanorods for living-cell imaging , 2015, Nano Research.

[17]  Yuanjin Zheng,et al.  Remarkable In Vivo Nonlinear Photoacoustic Imaging Based on Near-Infrared Organic Dyes. , 2016, Small.

[18]  Colloidal CuFeS2 Nanocrystals: Intermediate Fe d-Band Leads to High Photothermal Conversion Efficiency , 2016, Chemistry of materials : a publication of the American Chemical Society.

[19]  N. Zheng,et al.  Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer , 2014, Nano Research.

[20]  Stanislav Emelianov,et al.  Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer. , 2009, Nano letters.

[21]  Zhen Gu,et al.  Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody. , 2016, Nano letters.

[22]  Yu Chen,et al.  Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery. , 2010, ACS nano.

[23]  Qian Chen,et al.  Recent advances in the development of organic photothermal nano-agents , 2015, Nano Research.

[24]  Jinping Wang,et al.  Targeted lipid–polyaniline hybrid nanoparticles for photoacoustic imaging guided photothermal therapy of cancer , 2016, Nanotechnology.

[25]  J. West,et al.  Near-infrared-resonant gold/gold sulfide nanoparticles as a photothermal cancer therapeutic agent. , 2010, Small.

[26]  Peng Huang,et al.  Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics. , 2015, ACS nano.

[27]  Pui-Chi Lo,et al.  pH- and Thiol-Responsive BODIPY-Based Photosensitizers for Targeted Photodynamic Therapy. , 2016, Chemistry.

[28]  R. Sabouni,et al.  Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs). , 2016, Current medicinal chemistry.

[29]  Wei Huang,et al.  Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy. , 2016, ACS applied materials & interfaces.

[30]  Xiaochen Dong,et al.  Diketopyrrolopyrrole Derivatives Grafting Hyaluronic Acid for Targeted Photodynamic Therapy , 2016 .

[31]  T. Okutsu,et al.  pH-Response Optimization of Amino-Substituted Tetraphenylporphyrin Derivatives as pH-Activatable Photosensitizers. , 2016, The journal of physical chemistry. A.

[32]  Deqing Zhang,et al.  Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics† †Electronic supplementary information (ESI) available: Synthesis and characterization of the intermediates and molecular orbital data. See DOI: 10.1039/c5sc , 2015, Chemical science.

[33]  B. Bandgar,et al.  Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents. , 2017, Bioorganic & medicinal chemistry letters.

[34]  Stanislav Emelianov,et al.  Biomedical photoacoustics beyond thermal expansion using triggered nanodroplet vaporization for contrast-enhanced imaging , 2012, Nature Communications.

[35]  Shuxiang Wang,et al.  Design and synthesis of novel 2-substituted 11-keto-boswellic acid heterocyclic derivatives as anti-prostate cancer agents with Pin1 inhibition ability. , 2017, European journal of medicinal chemistry.

[36]  R. Misra,et al.  Tetracyanobutadiene functionalized ferrocenyl BODIPY dyes. , 2016, Dalton transactions.

[37]  H. Dai,et al.  High performance in vivo near-IR (>1 μm) imaging and photothermal cancer therapy with carbon nanotubes , 2010, Nano research.

[38]  Feng Gao,et al.  In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages. , 2010, ACS nano.

[39]  Sen Xin,et al.  Biotemplated synthesis of three-dimensional porous MnO/C-N nanocomposites from renewable rapeseed pollen: An anode material for lithium-ion batteries , 2016, Nano Research.

[40]  Weizhi Wang,et al.  Narrow band-gap donor–acceptor copolymers based on diketopyrrolopyrrole and diphenylethene: Synthesis, characterization and application in field effect transistor , 2016 .

[41]  J. Karp,et al.  Nanocarriers as an Emerging Platform for Cancer Therapy , 2022 .

[42]  Rujia Zou,et al.  Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. , 2011, ACS nano.

[43]  B. Wilson,et al.  FRET quenching of photosensitizer singlet oxygen generation. , 2009, The journal of physical chemistry. B.

[44]  S. Emelianov,et al.  Silica-coated gold nanorods as photoacoustic signal nanoamplifiers. , 2011, Nano letters.

[45]  X. Jing,et al.  Thiadiazole molecules and poly(ethylene glycol)-block-polylactide self-assembled nanoparticles as effective photothermal agents. , 2015, Colloids and surfaces. B, Biointerfaces.

[46]  M. Ferrari Cancer nanotechnology: opportunities and challenges , 2005, Nature Reviews Cancer.

[47]  Nastassja A. Lewinski,et al.  Cytotoxicity of nanoparticles. , 2008, Small.

[48]  C. Ornelas Application of ferrocene and its derivatives in cancer research , 2011 .

[49]  Jing Bai,et al.  Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. , 2016, Nanoscale.

[50]  J. Schlager,et al.  In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[51]  Peng Chen,et al.  Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy , 2017, Nano Research.

[52]  Kai Yang,et al.  Organic stealth nanoparticles for highly effective in vivo near-infrared photothermal therapy of cancer. , 2012, ACS nano.

[53]  Sanjiv S Gambhir,et al.  Family of enhanced photoacoustic imaging agents for high-sensitivity and multiplexing studies in living mice. , 2012, ACS nano.

[54]  Jinzhong Zhang,et al.  Photothermal ablation therapy for cancer based on metal nanostructures , 2009 .