Severe infections after single umbilical cord blood transplantation in adults with or without the co‐infusion of CD34+ cells from a third‐party donor: results of a multicenter study from the Grupo Español de Trasplante Hematopoyético (GETH)

Umbilical cord blood transplantation (CBT) is an established alternative source of stem cells in the setting of unrelated transplantation. When compared with other sources, single‐unit CBT (sCBT) is associated with a delayed hematologic recovery, which may lead to a higher infection‐related mortality (IRM). Co‐infusion with the sCBT of CD34+ peripheral blood stem cells from a third‐party donor (TPD) (sCBT + TPDCD34+) has been shown to markedly accelerate leukocyte recovery, potentially reducing the IRM. However, to our knowledge, no comparative studies have focused on severe infections and IRM with these 2 sCBT strategies.

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