Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure
暂无分享,去创建一个
C. Spencer | P. Klenerman | J. Fellay | P. Simmonds | J. Bukh | R. Bowden | G. Cooke | E. Barnes | S. Khakoo | P. Vickerman | J. McKeating | N. Zitzmann | A. Miners | V. Pedergnana | J. McLauchlan | W. Irving | M. Ansari | G. Burgess | G. Foster | R. Halford | C. Holmes | E. Hudson | N. Martin | T. Mbisa | A. Murray | P. Shaw | E. Thomson | D. Brainard | J. McHutchison | P. Targett-Adams | A. Magrì | C. Gore | N. Chaturvedi | David A. Smith | A. Howe | J. Ball | J. Dillon | S. Ramirez | D. Koletzki | B. Massetto | W. Irving | Carlota Fernandez-Antunez | Neil Guha | C. Herath | Jonathan Diana Gary Graham John Charles Neil Rachel Cham Ch Ball Brainard Burgess Cooke Dillon Gore | C. Spencer | J. Mchutchison
[1] A. G. Pedersen,et al. Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non‐target sites, for DAA‐based treatment and retreatment outcome , 2020, Journal of viral hepatitis.
[2] J. Bukh,et al. Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity , 2020, Antimicrobial Agents and Chemotherapy.
[3] J. Bukh,et al. Mutations identified in the HCV polymerase of ribavirin treated chronic hepatitis C patients cause resistance and affect viral replication fidelity. , 2020, Antimicrobial agents and chemotherapy.
[4] J. McLauchlan,et al. An interferon lambda 4-associated variant in the hepatitis C virus RNA polymerase affects viral replication in infected cells , 2020, The Journal of general virology.
[5] E. Domingo,et al. Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure. , 2019, Antiviral research.
[6] E. Barnes,et al. Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir , 2019, Gastroenterology.
[7] L. Cuypers,et al. Next-generation sequencing for the clinical management of hepatitis C virus infections: does one test fits all purposes? , 2019, Critical reviews in clinical laboratory sciences.
[8] Kinh Nguyen Van,et al. Sofosbuvir-velpatasvir for treatment of chronic hepatitis C virus infection in Asia: a single-arm, open-label, phase 3 trial. , 2019, The lancet. Gastroenterology & hepatology.
[9] J. Pawlotsky,et al. Frequent Antiviral Treatment Failures in Patients Infected With Hepatitis C Virus Genotype 4, Subtype 4r , 2019, Hepatology.
[10] J. Bukh,et al. Full-Length Open Reading Frame Amplification of Hepatitis C Virus. , 2018, Methods in molecular biology.
[11] P. Simmonds,et al. Resistance analysis of genotype 3 hepatitis C virus indicates subtypes inherently resistant to nonstructural protein 5A inhibitors , 2018, Hepatology.
[12] Jean-Michel Pawlotsky,et al. EASL Recommendations on Treatment of Hepatitis C 2018. , 2018, Journal of hepatology.
[13] J. Bukh,et al. HCV Genotype 6a Escape From and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models. , 2018, Gastroenterology.
[14] P. Simmonds,et al. Resistance analysis of genotype 3 HCV indicates subtypes inherently resistant to NS5A inhibitors. , 2018 .
[15] M. Buti,et al. Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals. , 2017, Gastroenterology.
[16] T. Hassanein,et al. Glecaprevir/pibrentasvir for hepatitis C virus genotype 3 patients with cirrhosis and/or prior treatment experience: A partially randomized phase 3 clinical trial , 2018, Hepatology.
[17] J. Hughes,et al. Response to DAA therapy in the NHS England Early Access Programme for rare HCV subtypes from low and middle income countries. , 2017, Journal of hepatology.
[18] H. Mo,et al. Global epidemiology of HCV subtypes and resistance-associated substitutions evaluated by sequencing-based subtype analyses. , 2017, Journal of hepatology.
[19] C. Stedman,et al. The emergence of NS5B resistance associated substitution S282T after sofosbuvir‐based treatment , 2017, Hepatology communications.
[20] C. Spencer,et al. Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus , 2017 .
[21] H. Mo,et al. Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir. , 2017, Journal of Hepatology.
[22] F. Ceccherini‐Silberstein,et al. Multiclass HCV resistance to direct‐acting antiviral failure in real‐life patients advocates for tailored second‐line therapies , 2017, Liver international : official journal of the International Association for the Study of the Liver.
[23] Alexander M. Fraser,et al. Cohort Profile: The Hepatitis C Virus (HCV) Research UK Clinical Database and Biobank , 2016, International journal of epidemiology.
[24] J. Pawlotsky,et al. EASL Recommendations on Treatment of Hepatitis C 2016. , 2017, Journal of hepatology.
[25] J. Bukh,et al. Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir. , 2016, Gastroenterology.
[26] H. Mo,et al. L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions. , 2016, The Journal of infectious diseases.
[27] X. Didelot,et al. Bayesian Inference of the Evolution of a Phenotype Distribution on a Phylogenetic Tree , 2016, Genetics.
[28] T. Asselah,et al. Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection. , 2015, The New England journal of medicine.
[29] E. Barnes,et al. Efficacy of sofosbuvir plus ribavirin with or without peginterferon-alfa in patients with hepatitis C virus genotype 3 infection and treatment-experienced patients with cirrhosis and hepatitis C virus genotype 2 infection. , 2015, Gastroenterology.
[30] David Bonsall,et al. ve-SEQ: Robust, unbiased enrichment for streamlined detection and whole-genome sequencing of HCV and other highly diverse pathogens , 2015, F1000Research.
[31] P. Klenerman,et al. The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design , 2015, Gut.
[32] L. Foster. Active Ageing: Voluntary Work by Older People in Europe, Andrea Principi, Per H. Jensen, and Giovanni Lamura, eds. , 2015 .
[33] L. Naeger,et al. Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir , 2015, Hepatology.
[34] N. Parkin,et al. Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials. , 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[35] Riina Salupere,et al. Sofosbuvir and ribavirin in HCV genotypes 2 and 3. , 2014, The New England journal of medicine.
[36] F. Penin,et al. Determinants for Membrane Association of the Hepatitis C Virus NS2 Protease Domain , 2014, Journal of Virology.
[37] S. So,et al. In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir. , 2014, The Journal of infectious diseases.
[38] Alexandros Stamatakis,et al. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies , 2014, Bioinform..
[39] S. Zeuzem,et al. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. , 2014, Journal of hepatology.
[40] Daniel J. Wilson,et al. A Modified RNA-Seq Approach for Whole Genome Sequencing of RNA Viruses from Faecal and Blood Samples , 2013, PLoS ONE.
[41] T. Liang,et al. The Application and Mechanism of Action of Ribavirin in Therapy of Hepatitis C , 2012, Antiviral chemistry & chemotherapy.
[42] Jieyun Jiang,et al. Cell Culture-Adaptive Mutations Promote Viral Protein-Protein Interactions and Morphogenesis of Infectious Hepatitis C Virus , 2012, Journal of Virology.
[43] D. Feigelstock,et al. Selection of hepatitis C virus resistant to ribavirin , 2011, Virology Journal.
[44] F. Penin,et al. Nonstructural protein 3‐4A: the Swiss army knife of hepatitis C virus , 2011, Journal of viral hepatitis.
[45] F. Penin,et al. NS2 Protein of Hepatitis C Virus Interacts with Structural and Non-Structural Proteins towards Virus Assembly , 2011, PLoS pathogens.
[46] M. Otto,et al. PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication , 2010, Antimicrobial Agents and Chemotherapy.
[47] F. Penin,et al. Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3 , 2009, Proceedings of the National Academy of Sciences.
[48] Zhuyan Guo,et al. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. , 2007, Journal of medicinal chemistry.
[49] C. Rice,et al. Structure of the catalytic domain of the hepatitis C virus NS2-3 protease , 2006, Nature.
[50] Toshiaki Maruyama,et al. Complete Replication of Hepatitis C Virus in Cell Culture , 2005, Science.
[51] C. Rice,et al. A second hepatitis C virus-encoded proteinase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[52] N. Kato,et al. Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus , 1993, Journal of virology.
[53] C. Dolea,et al. World Health Organization , 1949, International Organization.