American Cancer Society Guideline for the Early Detection of Cervical Neoplasia and Cancer

An update to the American Cancer Society (ACS) guideline regarding screening for the early detection of cervical neoplasia and cancer, based on recommendations from a formal review and recent workshop, is presented. The new screening recommendations address when to begin screening, when screening may be discontinued, whether to screen women who have had a hysterectomy, appropriate screening intervals, and new screening technologies, including liquid‐based cytology and HPV DNA testing.

[1]  T. Nolan,et al.  Cytopathological findings on vaginal Papanicolaou smears after hysterectomy for benign gynecologic disease. , 1996, The New England journal of medicine.

[2]  T. Wright,et al.  HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancer. , 2000, JAMA.

[3]  David R. Scott,et al.  Persistence of type-specific human papillomavirus infection among cytologically normal women. , 1994, The Journal of infectious diseases.

[4]  H. Kitchener,et al.  Efficacy of cervical-smear collection devices: a systematic review and meta-analysis , 1999, The Lancet.

[5]  G. Kristensen,et al.  Analysis of cervical smears obtained within three years of the diagnosis of invasive cervical cancer. , 1991, Acta cytologica.

[6]  David R. Scott,et al.  Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis. , 2003, Journal of the National Cancer Institute.

[7]  D J Zahniser,et al.  Homogeneous sampling accounts for the increased diagnostic accuracy using the ThinPrep Processor. , 1994, American journal of clinical pathology.

[8]  V. Kataja,et al.  Natural History of Cervical Human Papillomavirus Lesions Does Not Substantiate the Biologic Relevance of the Bethesda System , 1992, Obstetrics and gynecology.

[9]  S. Mount,et al.  A study of 10,296 pediatric and adolescent Papanicolaou smear diagnoses in northern New England. , 1999, Pediatrics.

[10]  C. Clavel,et al.  Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women , 2001, British Journal of Cancer.

[11]  P. Frame,et al.  Determinants of Cancer Screening Frequency: The Example of Screening for Cervical Cancer , 1998, The Journal of the American Board of Family Medicine.

[12]  R. Ca.  The false negative smear. II. The trapping effect of collecting instruments. , 1977 .

[13]  W. Hoskins,et al.  Biologic course of cervical human papillomavirus infection , 1987, Obstetrics and gynecology.

[14]  C. Wheeler,et al.  Risk factors for rapid-onset cervical cancer. , 1999, American journal of obstetrics and gynecology.

[15]  J. Obwegeser,et al.  Does Liquid-Based Technology Really Improve Detection of Cervical Neoplasia? , 2001, Acta Cytologica.

[16]  S. Sato,et al.  Cervical cancer screening in Japan. A case-control study. , 1997, Acta cytologica.

[17]  Screening for squamous cervical cancer: duration of low risk after negative results of cervical cytology and its implication for screening policies. IARC Working Group on evaluation of cervical cancer screening programmes. , 1986, British medical journal.

[18]  K. Shah,et al.  Adjunctive testing for cervical cancer in low resource settings with visual inspection, HPV, and the Pap smear , 2001, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[19]  C. Rubio.  The False Negative Smear: II. The Trapping Effect of Collecting Instruments , 1977, Obstetrics and gynecology.

[20]  M. Henry,et al.  A Comparison of the Three Most Common Papanicolaou Smear Collection Techniques , 1994, Obstetrics and gynecology.

[21]  K. Kerlikowske,et al.  The Positive Predictive Value of Cervical Smears in Previously Screened Postmenopausal Women: The Heart and Estrogen/progestin Replacement Study (HERS) , 2000, Annals of Internal Medicine.

[22]  R. Fawdry.  Long term follow up of women after hysterectomy with a history of pre‐invasive cancer of the cervix , 1993, British journal of obstetrics and gynaecology.

[23]  R. Holloway,et al.  The efficacy and safety of the cytobrush during pregnancy. , 1992, Gynecologic oncology.

[24]  M. Hakama,et al.  Risk of cervical cancer after a negative Pap smear , 1999, Journal of medical screening.

[25]  R. Ashfaq,et al.  Comparison of conventional Papanicolaou smears and a fluid-based, thin-layer system for cervical cancer screening , 1997 .

[26]  T. Wright,et al.  Human papillomavirus DNA testing for cervical cancer screening in low-resource settings. , 2000, Journal of the National Cancer Institute.

[27]  M. Denniston,et al.  Routine Vaginal Cuff Smear Testing in Post-Hysterectomy Patients With Benign Uterine Conditions: When Is It Indicated? , 2000, The Journal of the American Board of Family Medicine.

[28]  M. Sherman,et al.  Utility of liquid‐based cytology for cervical carcinoma screening , 1999, Cancer.

[29]  M. Boon,et al.  Analysis of five sampling methods for the preparation of cervical smears. , 1989, Acta cytologica.

[30]  Frequency of Cervical Smear Abnormalities Within 3 Years of Normal Cytology , 2000, Obstetrics and gynecology.

[31]  A. Miller,et al.  Natural history of dysplasia of the uterine cervix. , 1999, Journal of the National Cancer Institute.

[32]  Thomas C Wright,et al.  2001 Consensus Guidelines for the Management of Women with Cervical Cytological Abnormalities. , 2002, Journal of lower genital tract disease.

[33]  Thomas C Wright,et al.  Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities , 2002 .

[34]  Julian Peto,et al.  Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective , 1995 .

[35]  D. Zahniser,et al.  Prevalence of cervical cancer and feasibility of screening in rural China: a pilot study for the Shanxi Province Cervical Cancer Screening Study. , 1999, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.

[36]  R. Ashfaq,et al.  ThinPrep Pap Test , 1999, Acta Cytologica.

[37]  Y. Qiao,et al.  Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia. , 2001, Gynecologic oncology.

[38]  Daniel S. Miller,et al.  Cervical Cancer Screening Among Low‐Income Women: Results of a National Screening Program, 1991–1995 , 1998, Obstetrics and gynecology.

[39]  M. Fremont-Smith,et al.  Direct-to-vial experience with AutoCyte PREP in a small New England regional cytology practice. , 2001, The Journal of reproductive medicine.

[40]  G. Vooijs,et al.  False negative rate in cervical cytology. , 1987, Journal of clinical pathology.

[41]  D. Fink.  Change in american cancer society checkup guidelines for detection of cervical cancer , 1988, CA: a cancer journal for clinicians.

[42]  E. Franco,et al.  Human papillomavirus testing for primary screening of cervical cancer precursors. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[43]  R. Kreienberg,et al.  Molecular biology of cervical cancer and its precursors. , 2002, Current women's health reports.

[44]  W. Lawrence,et al.  Benefits and costs of using HPV testing to screen for cervical cancer. , 2002, JAMA.

[45]  A. Gafni,et al.  Evidence-based vs emotion-based medical decision-making: routine preoperative HIV testing vs universal precautions. , 1993, Journal of clinical epidemiology.

[46]  V. Wright,et al.  Cyto‐histological correlates in a colposcopic clinic: A 1‐year prospective study , 1991, Diagnostic cytopathology.

[47]  Mark Sherman,et al.  The 2001 Bethesda System: terminology for reporting results of cervical cytology. , 2002, JAMA.

[48]  J. Hecht,et al.  Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin‐layer preparations , 2002, Cancer.

[49]  K Shy,et al.  Papanicolaou smear screening interval and risk of cervical cancer , 1989, Obstetrics and gynecology.

[50]  J. Mandelblatt,et al.  Gynecological care of elderly women. Another look at Papanicolaou smear testing. , 1986, JAMA.

[51]  C. Clavel,et al.  Hybrid Capture II-based human papillomavirus detection, a sensitive test to detect in routine high-grade cervical lesions: a preliminary study on 1518 women , 1999, British Journal of Cancer.

[52]  J. Ward.  Population‐based mammographic screening: Does Informed choice‘ require any less than full disclosure to individuals of benefits, harms, limitations and consequences? , 1999, Australian and New Zealand journal of public health.

[53]  V. Václavinková.  Behavior of Moderate Cervical Dysplasia During Long-Term Follow-Up , 1983, Obstetrics and gynecology.

[54]  T. Wright,et al.  Cost-effectiveness of alternative triage strategies for atypical squamous cells of undetermined significance. , 2002, JAMA.

[55]  K. Sigurdsson,et al.  Trends in cervical intra‐epithelial neoplasia in Iceland through 1995, Evaluation of targeted age groups and screening intervals , 1999, Acta obstetricia et gynecologica Scandinavica.

[56]  Performance of a semiautomated papanicolaou smear screening system , 1998 .

[57]  H. Adami,et al.  Low efficiency of cytologic screening for cancer in situ of the cervix in older women , 1995, International journal of cancer.

[58]  C. la Vecchia,et al.  Screening practices and invasive cervical cancer risk in different age strata. , 1990, Gynecologic oncology.

[59]  A. Moscicki,et al.  The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. , 1998, The Journal of pediatrics.

[60]  K R Lee,et al.  Comparison of Conventional Papanicolaou Smears and a Fluid‐Based, Thin‐Layer System for Cervical Cancer Screening , 1997, Obstetrics and gynecology.

[61]  J. T. Cox,et al.  ASCCP Patient Management Guidelines: Pap Test Specimen Adequacy and Quality Indicators , 2002, Journal of lower genital tract disease.

[62]  D. Simel,et al.  Cytologic screening after hysterectomy for benign disease. , 1995, American journal of obstetrics and gynecology.

[63]  P Sasieni,et al.  Women's understanding of a “normal smear test result”: experimental questionnaire based study , 2001, BMJ : British Medical Journal.

[64]  E. Lynge,et al.  Risk of cervical cancer following negative smears in Maribo County, Denmark, 1966-1982. , 1986, IARC scientific publications.

[65]  M. Boon,et al.  Diagnostic accuracy of squamous cervical lesions studied in spatula-cytobrush smears. , 1988, Acta Cytologica.

[66]  J. Peto,et al.  Human papillomavirus is a necessary cause of invasive cervical cancer worldwide , 1999, The Journal of pathology.

[67]  R. Burk,et al.  Natural history of cervicovaginal papillomavirus infection in young women , 1998 .

[68]  F. Guijon,et al.  Brush vs. spatula for cervical smears. Histologic correlation with concurrent biopsies. , 1994, Acta cytologica.

[69]  V. Moreno,et al.  Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. , 1995, Journal of the National Cancer Institute.

[70]  J. Cuzick,et al.  Estimating the efficacy of screening by auditing smear histories of women with and without cervical cancer. The National Co-ordinating Network for Cervical Screening Working Group. , 1996, British Journal of Cancer.

[71]  G. Javaheri,et al.  Cervical cytology after cryosurgery, laser ablation and conization. A comparison of the cotton swab and endocervical brush. , 1993, Acta cytologica.

[72]  A. Ferenczy,et al.  Assessing gains in diagnostic utility when human papillomavirus testing is used as an adjunct to papanicolaou smear in the triage of women with cervical cytologic abnormalities. , 1999, American journal of obstetrics and gynecology.

[73]  J. Cuzick,et al.  HPV testing in primary screening of older women , 1999, British Journal of Cancer.

[74]  M. Nasiell,et al.  Behavior of mild cervical dysplasia during long‐term follow‐up , 1987, Obstetrics and gynecology.

[75]  I. Duncan,et al.  Rationale for stopping cervical screening in women over 50. , 1993, BMJ.

[76]  Y. Qiao,et al.  Primary Screening with Liquid-Based Cytology in an Unscreened Population in Rural China, with an Emphasis on Reprocessing Unsatisfactory Samples , 2002, Acta Cytologica.

[77]  C. Sung,et al.  ThinPrep® pap test promotes detection of glandular lesions of the endocervix , 1999, Diagnostic cytopathology.

[78]  S. Kabawat,et al.  Performance of a fluid-based, thin-layer papanicolaou smear method in the clinical setting of an independent laboratory and an outpatient screening population in New England. , 2009, Archives of pathology & laboratory medicine.

[79]  L Beardsley,et al.  Natural history of cervicovaginal papillomavirus infection in young women. , 1998, The New England journal of medicine.

[80]  D. Provenzale,et al.  Patient preferences and quality of life associated with colorectal cancer screening. , 1997, The American journal of gastroenterology.

[81]  P. Remington,et al.  The effect of hysterectomy on the risk of an abnormal screening Papanicolaou test result. , 2000, American journal of obstetrics and gynecology.

[82]  S Wacholder,et al.  HPV DNA testing in cervical cancer screening: results from women in a high-risk province of Costa Rica. , 2000, JAMA.