Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies.

[1]  D. Schuppan,et al.  Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro. , 2007, Journal of hepatology.

[2]  J. Fallowfield,et al.  Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis1 , 2007, The Journal of Immunology.

[3]  J. Schwarzbauer,et al.  Modulation of cell-fibronectin matrix interactions during tissue repair. , 2006, The journal of investigative dermatology. Symposium proceedings.

[4]  D. Schuppan,et al.  Halofuginone Induces Matrix Metalloproteinases in Rat Hepatic Stellate Cells via Activation of p38 and NFκB* , 2006, Journal of Biological Chemistry.

[5]  Yury Popov,et al.  Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. , 2005, Journal of hepatology.

[6]  M. Jinnin,et al.  Increased Expression of Integrin αvβ3 Contributes to the Establishment of Autocrine TGF-β Signaling in Scleroderma Fibroblasts1 , 2005, The Journal of Immunology.

[7]  T. Salo,et al.  αvβ6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells , 2005 .

[8]  G. Ramm,et al.  Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity. , 2005, Surgery.

[9]  D. Brenner,et al.  Erratum: Liver fibrosis (Journal of Clinical Investigation (2005) 115 (209-218) DOI:10.1172/JCI200524282) , 2005 .

[10]  D. Schuppan,et al.  Matrix metalloproteinase pattern in celiac duodenal mucosa , 2005, Laboratory Investigation.

[11]  P. Oettgen,et al.  Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. , 2005, The Journal of clinical investigation.

[12]  D. Rockey.  Antifibrotic therapy in chronic liver disease. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[13]  S. Forbes,et al.  Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. , 2005, The Journal of clinical investigation.

[14]  S. Friedman,et al.  Mechanisms of Disease: mechanisms of hepatic fibrosis and therapeutic implications , 2004, Nature Clinical Practice Gastroenterology &Hepatology.

[15]  W. Frederiks,et al.  Metabolic Mapping of Proteinase Activity with Emphasis on In Situ Zymography of Gelatinases , 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[16]  J. Fallowfield,et al.  Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. , 2004, Gastroenterology.

[17]  R. Kalluri,et al.  Epithelial-mesenchymal transition and its implications for fibrosis. , 2003, The Journal of clinical investigation.

[18]  G. Gores,et al.  Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression , 2003, Hepatology.

[19]  D. Schuppan,et al.  Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells. , 2003, The American journal of pathology.

[20]  N. Kaminski,et al.  Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema , 2003, Nature.

[21]  E. Schiff,et al.  Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection , 2002, American Journal of Gastroenterology.

[22]  I. Macreadie,et al.  Direct integrin αvβ6-ERK binding: implications for tumour growth , 2002, Oncogene.

[23]  Horst Kessler,et al.  Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 Integrins , 2002 .

[24]  B. McMahon,et al.  Chronic hepatitis B , 2001, Hepatology.

[25]  D. Schuppan,et al.  Matrix as a modulator of hepatic fibrogenesis. , 2001, Seminars in liver disease.

[26]  F. Marra,et al.  Cytokine Receptors and Signaling in Hepatic Stellate Cells , 2001, Seminars in liver disease.

[27]  T. Roskams,et al.  Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. , 2001, Journal of hepatology.

[28]  D. Schuppan,et al.  Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. , 2001, The American journal of pathology.

[29]  D. Valla,et al.  Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. , 2001, The New England journal of medicine.

[30]  T. Krieg,et al.  Fibroblast-matrix interactions in wound healing and fibrosis. , 2000, Matrix biology : journal of the International Society for Matrix Biology.

[31]  D. Schuppan,et al.  An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis. , 2000, Gastroenterology.

[32]  F. Piscaglia,et al.  Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. , 1999, Gastroenterology.

[33]  C. Garret,et al.  A randomized, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia. , 1999, Gastroenterology.

[34]  H. Herbst,et al.  Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats. , 1999, Journal of hepatology.

[35]  N. Kaminski,et al.  The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.

[36]  A. Kossakowska,et al.  Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis. , 1998, The American journal of pathology.

[37]  D. Sheppard,et al.  The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. , 1998, Journal of cell science.

[38]  V. Desmet.  Histopathology of chronic cholestasis and adult ductopenic syndrome. , 1998, Clinics in liver disease.

[39]  M. Kaplan,et al.  Reversibility of Hepatic Fibrosis in Autoimmune Hepatitis , 1997, Annals of Internal Medicine.

[40]  D. Schuppan,et al.  Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats , 1997, Hepatology.

[41]  D. Schuppan,et al.  Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis. , 1997, The American journal of pathology.

[42]  D. Sheppard,et al.  Differential regulation of airway epithelial integrins by growth factors. , 1996, American journal of respiratory cell and molecular biology.

[43]  D. Sheppard,et al.  Identification of a Sequence within the Integrin β6 Subunit Cytoplasmic Domain That Is Required to Support the Specific Effect of αvβ6 on Proliferation in Three-dimensional Culture* , 1996, The Journal of Biological Chemistry.

[44]  H. Herbst,et al.  Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. , 1996, The American journal of pathology.

[45]  T. Krieg,et al.  Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins , 1995, The Journal of cell biology.

[46]  K. Batts,et al.  Chronic hepatitis. An update on terminology and reporting. , 1995, The American journal of surgical pathology.

[47]  D. Schuppan,et al.  Kupffer cell–derived 95‐kd type IV collagenase/gelatinase B: Characterization and expression in cultured cells , 1995, Hepatology.

[48]  K. Aldape,et al.  Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. , 1995, Journal of cell science.

[49]  D. Sheppard,et al.  The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain , 1994, The Journal of cell biology.

[50]  D. Sheppard,et al.  Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. , 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[51]  H. Stein,et al.  Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. , 1991, The American journal of pathology.

[52]  H. Stein,et al.  Cellular localization of laminin gene transcripts in normal and fibrotic human liver. , 1989, The American journal of pathology.

[53]  T. Salo,et al.  Alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells. , 2005, Experimental cell research.

[54]  M. Jinnin,et al.  Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. , 2005, Journal of immunology.

[55]  S. Goodman,et al.  Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro. , 2004, Histopathology.

[56]  H. Larjava,et al.  Increased expression of beta6-integrin in skin leads to spontaneous development of chronic wounds. , 2004, The American journal of pathology.

[57]  N. Kaminski,et al.  Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. , 2003, Nature.

[58]  E. Schiff,et al.  Histological outcome during long-term lamivudine therapy. , 2003, Gastroenterology.

[59]  S. Goodman,et al.  Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins. , 2002, Journal of medicinal chemistry.

[60]  I. Macreadie,et al.  Direct integrin alphavbeta6-ERK binding: implications for tumour growth. , 2002, Oncogene.

[61]  J. Chen,et al.  Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture. , 1996, The Journal of biological chemistry.

[62]  H. Stein,et al.  Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis. , 1990, Gastroenterology.