Simulator of a Full Fetal Electrocardiogram Measurement Chain by Multichannel Capacitive Sensing

Long-term ambulatory monitoring of the fetal heart rate (fHR) can greatly increase insight into fetal well-being and reduce pregnancy risks. Unfortunately, the existing solutions using wet or dry electrodes are unsuitable for long-term fHR monitoring due to the use of a gel or direct skin contact. Capacitive electrodes can measure an electrocardiographic (ECG) signal through clothes and, therefore, are perfectly suitable for long-term monitoring of the fHR. However, capacitive fetal ECG (fECG) measurements are challenging due to the high sensitivity of capacitive sensors to motion artifacts (MAs) and the low amplitude of the fECG. This article aims at investigating the feasibility of fECG measurements using capacitive electrodes with dedicated postprocessing algorithms for signal-to-noise ratio (SNR) improvement and MA reduction. To this end, a novel simulator of the full measurement chain is realized that generates multichannel capacitive fECG data with artificial MAs and system noise. A dedicated blind source separation (BSS) algorithm is then employed for MA removal and fECG extraction. The extracted fECG is evaluated by SNR calculation and R-peak detection. Our results show that the BSS algorithm may extract the fECG signal from noisy capacitive data. In addition, lower system noise or higher number of channels may lead to better fECG extraction. A maximum increase of 0.5 dB in the SNR and decrease of 80.7 % in the R-peak detection error are observed with increased electrode number from 8 to 20. Our findings provide useful insights for the hardware design of a capacitive fECG measurement system.

[1]  J. Webster,et al.  Minimizing Electrode Motion Artifact by Skin Abrasion , 1977, IEEE Transactions on Biomedical Engineering.

[2]  Steffen Leonhardt,et al.  A Multi-Modal Sensor for a Bed-Integrated Unobtrusive Vital Signs Sensing Array , 2019, IEEE Transactions on Biomedical Circuits and Systems.

[3]  Massimo Mischi,et al.  Low-complexity R-peak detection for ambulatory fetal monitoring , 2012, Physiological measurement.

[4]  Steffen Leonhardt,et al.  Triboelectricity in Capacitive Biopotential Measurements , 2011, IEEE Transactions on Biomedical Engineering.

[5]  Shuang Song,et al.  A Low-Voltage Chopper-Stabilized Amplifier for Fetal ECG Monitoring With a 1.41 Power Efficiency Factor , 2015, IEEE Transactions on Biomedical Circuits and Systems.

[6]  Mark F. Bocko,et al.  Non-contact ECG employing signal compensation , 2013, 2013 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[7]  Xi Long,et al.  Automated preterm infant sleep staging using capacitive electrocardiography , 2019, Physiological measurement.

[8]  Jens Kirchner,et al.  Passive Capacitive ECG Sensing: Assessment of Signal Quality During Different Types of Body Movement , 2018, 2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA).

[9]  Ralf Bousseljot,et al.  Nutzung der EKG-Signaldatenbank CARDIODAT der PTB über das Internet , 2009 .

[10]  H. Leonard,et al.  Risk of Stillbirth, Preterm Delivery, and Fetal Growth Restriction Following Exposure in a Previous Birth: Systematic Review and Meta-analysis , 2018, Obstetrical & Gynecological Survey.

[11]  Erkki Oja,et al.  A class of neural networks for independent component analysis , 1997, IEEE Trans. Neural Networks.

[12]  Shuang Song,et al.  Influence of Electrode Placement on Signal Quality for Ambulatory Pregnancy Monitoring , 2014, Comput. Math. Methods Medicine.

[13]  Leif Sörnmo,et al.  Spatiotemporal QRST cancellation techniques for analysis of atrial fibrillation , 2001, IEEE Transactions on Biomedical Engineering.

[14]  Tzyy-Ping Jung,et al.  Dry-Contact and Noncontact Biopotential Electrodes: Methodological Review , 2010, IEEE Reviews in Biomedical Engineering.

[15]  Steffen Leonhardt,et al.  Closed-Loop Control of Humidification for Artifact Reduction in Capacitive ECG Measurements , 2017, IEEE Transactions on Biomedical Circuits and Systems.

[16]  Sebastian Zaunseder,et al.  An ECG simulator for generating maternal-foetal activity mixtures on abdominal ECG recordings , 2014, Physiological measurement.

[17]  Chris Van Hoof,et al.  Robust wireless capacitive ECG system with adaptive signal quality and motion artifact reduction , 2016, 2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA).

[18]  C H L Peters,et al.  A robust physiology-based source separation method for QRS detection in low amplitude fetal ECG recordings , 2010, Physiological measurement.

[19]  Patrick E. McSharry,et al.  A dynamical model for generating synthetic electrocardiogram signals , 2003, IEEE Transactions on Biomedical Engineering.

[20]  Jean-François Cardoso,et al.  Equivariant adaptive source separation , 1996, IEEE Trans. Signal Process..

[21]  Christian Jutten,et al.  Multichannel ECG and Noise Modeling: Application to Maternal and Fetal ECG Signals , 2007, EURASIP J. Adv. Signal Process..

[22]  Stephan Heuer,et al.  Motion Artefacts in Capacitively Coupled ECG Electrodes , 2009 .

[23]  A. Cahill,et al.  Electronic fetal monitoring: past, present, and future. , 2011, Clinics in perinatology.

[24]  Pieter Harpe,et al.  Motion-Artifact Reduction in Capacitive Heart-Rate Measurements by Adaptive Filtering , 2019, IEEE Transactions on Instrumentation and Measurement.

[25]  Jan W. M. Bergmans,et al.  An Improved Adaptive Power Line Interference Canceller for Electrocardiography , 2006, IEEE Transactions on Biomedical Engineering.

[26]  Lin Xu,et al.  Adaptive motion-artifact reduction in capacitive ECG measurements by using the power-line interference , 2018, 2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA).

[27]  P. C. Richardson,et al.  Capacitive electrocardiographic and bioelectric electrodes. , 1969, IEEE transactions on bio-medical engineering.

[28]  Aapo Hyvärinen,et al.  Fast and robust fixed-point algorithms for independent component analysis , 1999, IEEE Trans. Neural Networks.

[29]  L. Billeci,et al.  An efficient unsupervised fetal QRS complex detection from abdominal maternal ECG , 2014, Physiological measurement.

[30]  Rik Vullings,et al.  Motion Artifacts in Capacitive ECG Measurements: Reducing the Combined Effect of DC Voltages and Capacitance Changes Using an Injection Signal , 2015, IEEE Transactions on Biomedical Engineering.

[31]  Christian Jutten,et al.  Multichannel ECG and Noise Modeling: Application to Maternal and Fetal ECG Signals , 2007 .

[32]  Steffen Leonhardt,et al.  ECG on the Road: Robust and Unobtrusive Estimation of Heart Rate , 2011, IEEE Transactions on Biomedical Engineering.

[33]  Pierre Comon,et al.  Independent component analysis, A new concept? , 1994, Signal Process..