The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

[1]  A. Maitra,et al.  Generation and testing of clinical-grade exosomes for pancreatic cancer. , 2018, JCI insight.

[2]  J. Shih,et al.  Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer , 2018, Molecular Cancer.

[3]  H. Wakelee,et al.  Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma , 2017, Annals of oncology : official journal of the European Society for Medical Oncology.

[4]  C. Zhang,et al.  Liver kinase B1 restoration promotes exosome secretion and motility of lung cancer cells , 2017, Oncology reports.

[5]  Gregory E. Rice,et al.  Tumor-derived exosomes in ovarian cancer – liquid biopsies for early detection and real-time monitoring of cancer progression , 2017, Oncotarget.

[6]  P. Pauwels,et al.  Exosomes as diagnostic and predictive biomarkers in lung cancer. , 2017, Journal of thoracic disease.

[7]  S. Fan,et al.  Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer , 2017, Journal of Cancer.

[8]  Jingxin Qiu,et al.  Circulating CD9+/GFAP+/survivin+ exosomes in malignant glioma patients following survivin vaccination , 2017, OncoTarget.

[9]  Guilin Yin,et al.  Biomarkers for early diagnosis, prognosis, prediction, and recurrence monitoring of non-small cell lung cancer , 2017, OncoTargets and therapy.

[10]  S. Hanash,et al.  Plasma-derived extracellular vesicle proteins as a source of biomarkers for lung adenocarcinoma , 2017, Oncotarget.

[11]  Jianbiao Zhou,et al.  Tumor-derived exosomes in colorectal cancer progression and their clinical applications , 2017, Oncotarget.

[12]  R. Blackwell,et al.  The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition , 2017, Cancers.

[13]  D. Xie,et al.  Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non–Small Cell Lung Cancer Using Next-Generation Sequencing , 2017, Clinical Cancer Research.

[14]  W. Wenyu,et al.  MiR-146a-5p level in serum exosomes predicts therapeutic effect of cisplatin in non-small cell lung cancer. , 2017, European review for medical and pharmacological sciences.

[15]  K. Selmaj,et al.  Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis , 2017, Annals of neurology.

[16]  J. Hung,et al.  Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1 , 2017, Oncogene.

[17]  M. Rickels,et al.  Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue , 2017, The Journal of clinical investigation.

[18]  T. Ochiya,et al.  Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[19]  Weijia Xie,et al.  Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer , 2016, Oncotarget.

[20]  A. Jemal,et al.  Cancer statistics, 2017 , 2017, CA: a cancer journal for clinicians.

[21]  S. Fan,et al.  The role of microRNAs in resistance to targeted treatments of non-small cell lung cancer , 2017, Cancer Chemotherapy and Pharmacology.

[22]  M. Catalán,et al.  Liquid Biopsy in Non-Small Cell Lung Cancer , 2016, Front. Med..

[23]  F. Sánchez‐Madrid,et al.  ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins , 2016, Nature Communications.

[24]  Zhen Wang,et al.  Exosomes in tumor microenvironment: novel transporters and biomarkers , 2016, Journal of Translational Medicine.

[25]  W. Mitzner,et al.  Bronchial Artery Angiogenesis Drives Lung Tumor Growth. , 2016, Cancer research.

[26]  T. Rasmussen,et al.  Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer , 2016, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[27]  C. Ihm,et al.  Exosome cargo reflects TGF-β1-mediated epithelial-to-mesenchymal transition (EMT) status in A549 human lung adenocarcinoma cells. , 2016, Biochemical and biophysical research communications.

[28]  B. Levy,et al.  Clinical Utility of Liquid Diagnostic Platforms in Non-Small Cell Lung Cancer. , 2016, The oncologist.

[29]  Yeqing Huang,et al.  Downregulation of miR-195 promotes prostate cancer progression by targeting HMGA1. , 2016, Oncology reports.

[30]  F. Lovat,et al.  Lung cancer exosomes as drivers of epithelial mesenchymal transition , 2016, Oncotarget.

[31]  Yili Wang,et al.  Exosomes-Derived MiR-302b Suppresses Lung Cancer Cell Proliferation and Migration via TGFβRII Inhibition , 2016, Cellular Physiology and Biochemistry.

[32]  W. D. van Marken Lichtenbelt,et al.  Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity , 2016, Nature Communications.

[33]  Hongling Li,et al.  Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway , 2016, Journal of Hematology & Oncology.

[34]  T. Whiteside Exosomes and tumor-mediated immune suppression. , 2016, The Journal of clinical investigation.

[35]  Raghu Kalluri,et al.  The biology and function of exosomes in cancer. , 2016, The Journal of clinical investigation.

[36]  F. Wang,et al.  Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy , 2016, Oncotarget.

[37]  A. Lucas,et al.  Tumor Microenvironment Derived Exosomes Pleiotropically Modulate Cancer Cell 1 Metabolism 2 , 2016 .

[38]  William E. Fondrie,et al.  Triple SILAC quantitative proteomic analysis reveals differential abundance of cell signaling proteins between normal and lung cancer-derived exosomes. , 2016, Journal of proteomics.

[39]  Yih-Leong Chang,et al.  The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitor-afatinib in lung adenocarcinoma patients , 2016, Oncotarget.

[40]  Meng Xu,et al.  The regulation of cancer cell migration by lung cancer cell-derived exosomes through TGF-β and IL-10. , 2016, Oncology letters.

[41]  A. Scott,et al.  Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting , 2016, Journal of extracellular vesicles.

[42]  P. Pauwels,et al.  P2.01-093 Exo-ALK Proof of Concept: Exosomal Analysis of ALK Alterations in Advanced NSCLC Patients , 2016 .

[43]  M. Biffoni,et al.  Generation, Quantification, and Tracing of Metabolically Labeled Fluorescent Exosomes. , 2016, Methods in molecular biology.

[44]  A. Allison,et al.  DIANNEXIN DOWN-MODULATES TNF-INDUCED ENDOTHELIAL MICROPARTICLE RELEASE BY BLOCKING MEMBRANE BUDDING PROCESS. , 2016, International journal of innovative medicine and health science.

[45]  Yu Qin,et al.  STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells. , 2016, Cancer letters.

[46]  B. Sandfeld-Paulsena,et al.  Exosomal proteins as prognostic biomarkers in non-small cell lung cancer. , 2016, Molecular oncology.

[47]  Z. Giricz,et al.  Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods , 2015, PloS one.

[48]  M. Amiji,et al.  Exosome mediated communication within the tumor microenvironment. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[49]  Myung Soo Kim,et al.  Using exosomes, naturally-equipped nanocarriers, for drug delivery. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[50]  G. Qin,et al.  Incidence and survival of non-small cell lung cancer in Shanghai: a population-based cohort study , 2015, BMJ Open.

[51]  S. Ramalingam,et al.  Targeting EGFR in lung cancer: Lessons learned and future perspectives. , 2015, Molecular aspects of medicine.

[52]  Gary K. Schwartz,et al.  Tumour exosome integrins determine organotropic metastasis , 2015, Nature.

[53]  B. Shen,et al.  Tumor-derived exosomes in cancer progression and treatment failure , 2015, Oncotarget.

[54]  J. Massagué,et al.  Surviving at a Distance: Organ-Specific Metastasis. , 2015, Trends in cancer.

[55]  N. Kosaka,et al.  Extracellular vesicles in lung microenvironment and pathogenesis. , 2015, Trends in molecular medicine.

[56]  M. Schlumpberger,et al.  Characterization of RNA from Exosomes and Other Extracellular Vesicles Isolated by a Novel Spin Column-Based Method , 2015, PloS one.

[57]  Tina Koestler,et al.  Abstract 545: Plasma-based diagnostics for detection of EML4-ALK fusion transcripts in NSCLC patients , 2015 .

[58]  Jin-ping Ren,et al.  MicroRNA let-7: Regulation, single nucleotide polymorphism, and therapy in lung cancer. , 2015, Journal of cancer research and therapeutics.

[59]  Lijun Wu,et al.  Exosomes in cancer: small particle, big player , 2015, Journal of Hematology & Oncology.

[60]  R. Agarwal,et al.  Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules , 2015, Molecular carcinogenesis.

[61]  R. Govindan,et al.  Genomic alterations in lung adenocarcinoma. , 2015, The Lancet. Oncology.

[62]  A. M. Belov,et al.  Mass-spectrometry-based molecular characterization of extracellular vesicles: lipidomics and proteomics. , 2015, Journal of proteome research.

[63]  Aleksandra Markovets,et al.  Acquired EGFR C797S mediates resistance to AZD9291 in advanced non-small cell lung cancer harboring EGFR T790M , 2015, Nature Medicine.

[64]  Z. Ling,et al.  Circulating miRNAs is a potential marker for gefitinib sensitivity and correlation with EGFR mutational status in human lung cancers. , 2015, American journal of cancer research.

[65]  Xuetao Cao,et al.  The exosomes in tumor immunity , 2015, Oncoimmunology.

[66]  L. Sequist,et al.  Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin. , 2015, The Lancet. Oncology.

[67]  R. Simpson,et al.  Exosomes and their roles in immune regulation and cancer. , 2015, Seminars in cell & developmental biology.

[68]  R. Soo,et al.  Molecular targeted therapy in the treatment of advanced stage non‐small cell lung cancer (NSCLC) , 2015, Respirology.

[69]  Emily Zeringer,et al.  Strategies for isolation of exosomes. , 2015, Cold Spring Harbor protocols.

[70]  P. Altevogt,et al.  Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment , 2015, Oncoimmunology.

[71]  Wei Liu,et al.  High expression of small GTPase Rab3D promotes cancer progression and metastasis , 2015, Oncotarget.

[72]  Jayoung Kim,et al.  Phospholipids of tumor extracellular vesicles stratify gefitinib‐resistant nonsmall cell lung cancer cells from gefitinib‐sensitive cells , 2015, Proteomics.

[73]  Wenting Liu,et al.  The role of exosomes and "exosomal shuttle microRNA" in tumorigenesis and drug resistance. , 2015, Cancer letters.

[74]  G. Dworacki,et al.  Exosomes – Structure, Biogenesis and Biological Role in Non‐Small‐Cell Lung Cancer , 2015, Scandinavian journal of immunology.

[75]  G. Cheng,et al.  Circulating miRNAs: roles in cancer diagnosis, prognosis and therapy. , 2015, Advanced drug delivery reviews.

[76]  F. Cappuzzo,et al.  First-line crizotinib versus chemotherapy in ALK-positive lung cancer. , 2014, The New England journal of medicine.

[77]  Renato Martins,et al.  Non-small cell lung cancer, version 1.2015. , 2014, Journal of the National Comprehensive Cancer Network : JNCCN.

[78]  G. Rossi,et al.  MET and Small-Cell Lung Cancer , 2014, Cancers.

[79]  A. Krüger,et al.  Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes , 2014, Oncogene.

[80]  Simon C Watkins,et al.  Isolation of biologically-active exosomes from human plasma. , 2014, Journal of immunological methods.

[81]  Jayoung Kim,et al.  Extracellular vesicles shed from gefitinib‐resistant nonsmall cell lung cancer regulate the tumor microenvironment , 2014, Proteomics.

[82]  S. Lawler,et al.  MicroRNAs in cancer: biomarkers, functions and therapy. , 2014, Trends in molecular medicine.

[83]  William Pao,et al.  AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. , 2014, Cancer discovery.

[84]  K. O'Byrne,et al.  Functions and Therapeutic Roles of Exosomes in Cancer , 2014, Front. Oncol..

[85]  A. Whetton,et al.  The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. , 2014, Cancer treatment reviews.

[86]  Makoto Nishio,et al.  The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. , 2014, Cancer discovery.

[87]  F. Petrucci,et al.  Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin , 2014, PloS one.

[88]  W. Jiang,et al.  Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes , 2014, Oncogene.

[89]  Alissa M. Weaver,et al.  Exosome secretion is enhanced by invadopodia and drives invasive behavior. , 2013, Cell reports.

[90]  Winston Patrick Kuo,et al.  Current methods for the isolation of extracellular vesicles , 2013, Biological chemistry.

[91]  S. Lim,et al.  Exosomes for drug delivery - a novel application for the mesenchymal stem cell. , 2013, Biotechnology advances.

[92]  B. Bao,et al.  Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review , 2013, Cancer and Metastasis Reviews.

[93]  Shao-hong Huang,et al.  Epidermal Growth Factor Receptor-Containing Exosomes Induce Tumor-Specific Regulatory T Cells , 2013, Cancer investigation.

[94]  K. Kinzler,et al.  Cancer Genome Landscapes , 2013, Science.

[95]  J. Engelman,et al.  ALK in lung cancer: past, present, and future. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[96]  C. Harding,et al.  Exosomes: Looking back three decades and into the future , 2013, The Journal of cell biology.

[97]  Graça Raposo,et al.  Extracellular vesicles: Exosomes, microvesicles, and friends , 2013, The Journal of cell biology.

[98]  Bernard Rachet,et al.  Lung cancer survival and stage at diagnosis in Australia, Canada, Denmark, Norway, Sweden and the UK: a population-based study, 2004–2007 , 2013, Thorax.

[99]  Chris Gardiner,et al.  Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis , 2013, Journal of extracellular vesicles.

[100]  T. Ochiya,et al.  Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

[101]  M. Michael,et al.  Hypoxic enhancement of exosome release by breast cancer cells , 2012, BMC Cancer.

[102]  Yuquan Wei,et al.  Enhancement of cisplatin sensitivity in lung cancer xenografts by liposome-mediated delivery of the plasmid expressing small hairpin RNA targeting Survivin. , 2012, Journal of biomedical nanotechnology.

[103]  Roberta Galli,et al.  MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response , 2012, Proceedings of the National Academy of Sciences.

[104]  C. Chen,et al.  Exosome removal as a therapeutic adjuvant in cancer , 2012, Journal of Translational Medicine.

[105]  F. Borràs,et al.  Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. , 2012, Journal of proteomics.

[106]  Gemma K. Alderton Metastasis: Exosomes drive premetastatic niche formation , 2012, Nature Reviews Cancer.

[107]  Ylva Ivarsson,et al.  Syndecan–syntenin–ALIX regulates the biogenesis of exosomes , 2012, Nature Cell Biology.

[108]  F. Sánchez‐Madrid,et al.  Intercellular communication: diverse structures for exchange of genetic information , 2012, Nature Reviews Molecular Cell Biology.

[109]  M. Campiglio,et al.  Potential role of HER2‐overexpressing exosomes in countering trastuzumab‐based therapy , 2012, Journal of cellular physiology.

[110]  Tatiana G. Kutateladze,et al.  Mechanisms of Resistance to Crizotinib in Patients with ALK Gene Rearranged Non–Small Cell Lung Cancer , 2012, Clinical Cancer Research.

[111]  M. Oppermann,et al.  Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3 , 2011, Proceedings of the National Academy of Sciences.

[112]  M. Wood,et al.  Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes , 2011, Nature Biotechnology.

[113]  S. Pomeroy,et al.  Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. , 2011, Nature communications.

[114]  T. Whiteside,et al.  Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg) , 2010, PloS one.

[115]  B. Chauffert,et al.  Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. , 2010, The Journal of clinical investigation.

[116]  Chow H Lee Reversing agents for ATP-binding cassette drug transporters. , 2010, Methods in molecular biology.

[117]  Miguel C. Seabra,et al.  Rab27a and Rab27b control different steps of the exosome secretion pathway , 2010, Nature Cell Biology.

[118]  Graça Raposo,et al.  Exosomes--vesicular carriers for intercellular communication. , 2009, Current opinion in cell biology.

[119]  G. Szakács,et al.  Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: substrates and/or inhibitors? , 2009, Current cancer drug targets.

[120]  Rune Matthiesen,et al.  Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. , 2008, Journal of proteome research.

[121]  S. Kaushal,et al.  Journal of Translational Medicine BioMed Central , 2008 .

[122]  J. Thiery,et al.  The physiology and pathology of the EMT Meeting on the Epithelial – Mesenchymal Transition , 2008 .

[123]  M. Bissell,et al.  Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. , 2007, Cancer research.

[124]  Daniel A. Haber,et al.  Epidermal growth factor receptor mutations in lung cancer , 2007, Nature Reviews Cancer.

[125]  L. Jin,et al.  Suppression of tumor growth using a recombinant adenoviral vector carrying the dominant-negative mutant gene Survivin-D53A in a nude mice model , 2006, Cancer Gene Therapy.

[126]  Aled Clayton,et al.  Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids , 2006, Current protocols in cell biology.

[127]  J. Minna,et al.  Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. , 2006, Journal of the National Cancer Institute.

[128]  M. Meyerson,et al.  EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. , 2005, The New England journal of medicine.

[129]  S. Gabriel,et al.  EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy , 2004, Science.

[130]  Patricia L. Harris,et al.  Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. , 2004, The New England journal of medicine.

[131]  A. M. George,et al.  The ABC transporter structure and mechanism: perspectives on recent research , 2004, Cellular and Molecular Life Sciences CMLS.

[132]  M. Vidal,et al.  Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells* , 2003, Journal of Biological Chemistry.

[133]  Sang‐wook Lee,et al.  Postoperative adjuvant chemotherapy and radiotherapy for stage II and III non-small cell lung cancer (NSCLC). , 2002, Lung cancer.

[134]  A. Régnault,et al.  TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex1 , 2002, The Journal of Immunology.

[135]  Laurence Zitvogel,et al.  Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming , 2001, Nature Medicine.

[136]  L. Mayer,et al.  Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. , 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[137]  Laurence Zitvogel,et al.  Molecular Characterization of Dendritic Cell-Derived Exosomes , 1999, The Journal of cell biology.

[138]  C. Melief,et al.  B lymphocytes secrete antigen-presenting vesicles , 1996, The Journal of experimental medicine.

[139]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[140]  M. Adam,et al.  Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes , 1985, The Journal of cell biology.

[141]  ' s report Title : Btbd 7 Contributes to reduced E-cadherin expression and Predicts Poor Prognosis in Non-small Cell Lung Cancer Version : 1 , 2022 .