Morpheus Unbound: Reimagining the Morphogen Gradient

[1]  H. Berg Random Walks in Biology , 2018 .

[2]  D. Odde,et al.  Potential for Control of Signaling Pathways via Cell Size and Shape , 2006, Current Biology.

[3]  D. Constam,et al.  The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. , 2006, Developmental cell.

[4]  Gregory T. Reeves,et al.  Quantitative models of developmental pattern formation. , 2006, Developmental cell.

[5]  David M. Umulis,et al.  Robust, bistable patterning of the dorsal surface of the Drosophila embryo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Luigi Martinelli,et al.  Quantifying the Gurken morphogen gradient in Drosophila oogenesis. , 2006, Developmental cell.

[7]  Krishanu Saha,et al.  Signal dynamics in Sonic hedgehog tissue patterning , 2006, Development.

[8]  James Briscoe,et al.  The interpretation of morphogen gradients , 2006, Development.

[9]  S. Eaton Release and trafficking of lipid-linked morphogens. , 2006, Current opinion in genetics & development.

[10]  W. Bialek,et al.  Diffusion and scaling during early embryonic pattern formation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Naama Barkai,et al.  Threshold responses to morphogen gradients by zero-order ultrasensitivity , 2005, Molecular systems biology.

[12]  David M. Umulis,et al.  Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing , 2005, Development.

[13]  S. Eaton,et al.  The endocytic pathway and formation of the Wingless morphogen gradient , 2005, Development.

[14]  Alexander F Schier,et al.  Molecular genetics of axis formation in zebrafish. , 2005, Annual review of genetics.

[15]  Dragana Rogulja,et al.  Regulation of Cell Proliferation by a Morphogen Gradient , 2005, Cell.

[16]  G. Blobe,et al.  Cell-surface co-receptors: emerging roles in signaling and human disease. , 2005, Trends in biochemical sciences.

[17]  W. Marshall,et al.  De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia , 2005, PLoS biology.

[18]  J. Marsh,et al.  Formation of the BMP activity gradient in the Drosophila embryo. , 2005, Developmental cell.

[19]  Q. Nie,et al.  Aggregation of a Distributed Source in Morphogen Gradient Formation , 2005, SIAM journal on applied dynamical systems.

[20]  Yu-Chiun Wang,et al.  Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning , 2005, Nature.

[21]  P. Vilmos,et al.  crossveinless defines a new family of Twisted‐gastrulation‐like modulators of bone morphogenetic protein signalling , 2005, EMBO reports.

[22]  Xinhua Lin,et al.  Functions of heparan sulfate proteoglycans in cell signaling during development , 2004, Development.

[23]  P. Pantazis,et al.  Robust formation of morphogen gradients. , 2004, Physical review letters.

[24]  O. Pourquié,et al.  Coupling segmentation to axis formation , 2004, Development.

[25]  Michael Brand,et al.  Endocytosis Controls Spreading and Effective Signaling Range of Fgf8 Protein , 2004, Current Biology.

[26]  Xinhua Lin,et al.  Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans , 2004, Cell.

[27]  Johannes Jaeger,et al.  Pattern formation and nuclear divisions are uncoupled in Drosophila segmentation: comparison of spatially discrete and continuous models , 2004 .

[28]  E. D. De Robertis,et al.  Dorsal-ventral patterning and neural induction in Xenopus embryos. , 2004, Annual review of cell and developmental biology.

[29]  P. Pantazis,et al.  Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model , 2004, Development.

[30]  J. Stelling,et al.  Robustness of Cellular Functions , 2004, Cell.

[31]  Stanislav Y. Shvartsman,et al.  Argos inhibits epidermal growth factor receptor signalling by ligand sequestration , 2004, Nature.

[32]  B. Ballarò,et al.  Reaction-diffusion equations for simulation of calcium signalling in cell systems. , 2004, Rivista di biologia.

[33]  David H. Sharp,et al.  Dynamic control of positional information in the early Drosophila embryo , 2004, Nature.

[34]  Nicholas T Ingolia,et al.  Topology and Robustness in the Drosophila Segment Polarity Network , 2004, PLoS biology.

[35]  Arthur D Lander,et al.  A Calculus of Purpose , 2004, PLoS biology.

[36]  D. Schaffer,et al.  The sonic hedgehog signaling system as a bistable genetic switch. , 2004, Biophysical journal.

[37]  E. Linney,et al.  Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo , 2004, Mechanisms of Development.

[38]  Y. Saijoh,et al.  Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo , 2004, Nature.

[39]  Tetsuya Tabata,et al.  Morphogens, their identification and regulation , 2004, Development.

[40]  Naama Barkai,et al.  Self-enhanced ligand degradation underlies robustness of morphogen gradients. , 2003, Developmental cell.

[41]  O. Shimmi,et al.  Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo , 2003, Development.

[42]  Yoshiaki Kawano,et al.  Secreted antagonists of the Wnt signalling pathway , 2003, Journal of Cell Science.

[43]  T. Matsuo,et al.  Dally regulates Dpp morphogen gradient formation in the Drosophila wing , 2003, Development.

[44]  Jeremy B. A. Green,et al.  Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment , 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

[45]  G. Odell,et al.  Design and constraints of the Drosophila segment polarity module: robust spatial patterning emerges from intertwined cell state switches. , 2002, The Journal of experimental zoology.

[46]  N. Barkai,et al.  Robustness of the BMP morphogen gradient in Drosophila embryonic patterning , 2002, Nature.

[47]  Pablo A. Iglesias,et al.  Modeling the Cell's Guidance System , 2002, Science's STKE.

[48]  Douglas A Lauffenburger,et al.  Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. , 2002, Development.

[49]  Qing Nie,et al.  Do morphogen gradients arise by diffusion? , 2002, Developmental cell.

[50]  G. Odell,et al.  Robustness, Flexibility, and the Role of Lateral Inhibition in the Neurogenic Network , 2002, Current Biology.

[51]  K. Cadigan Regulating morphogen gradients in the Drosophila wing. , 2002, Seminars in cell & developmental biology.

[52]  L. Hood,et al.  A Genomic Regulatory Network for Development , 2002, Science.

[53]  C. Rauskolb,et al.  Boundaries in development: formation and function. , 2001, Annual review of cell and developmental biology.

[54]  S. Eaton,et al.  Argosomes A Potential Vehicle for the Spread of Morphogens through Epithelia , 2001, Cell.

[55]  Peter A. Lawrence,et al.  Morphogens: how big is the big picture? , 2001, Nature Cell Biology.

[56]  Stephen C. Ekker,et al.  Twisted gastrulation is a conserved extracellular BMP antagonist , 2001, Nature.

[57]  R. Dorfman,et al.  Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region. , 2001, Development.

[58]  S. Hanes,et al.  Isolation of mutations that disrupt cooperative DNA binding by the Drosophila bicoid protein. , 2001, Journal of molecular biology.

[59]  A. Teleman,et al.  Dpp Gradient Formation in the Drosophila Wing Imaginal Disc , 2000, Cell.

[60]  Marcos González-Gaitán,et al.  Gradient Formation of the TGF-β Homolog Dpp , 2000, Cell.

[61]  H. Meinhardt,et al.  Pattern formation by local self-activation and lateral inhibition. , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[62]  G. Odell,et al.  The segment polarity network is a robust developmental module , 2000, Nature.

[63]  M. Ehrenberg,et al.  Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[64]  J. Christian,et al.  BMP, Wnt and Hedgehog signals: how far can they go? , 2000, Current opinion in cell biology.

[65]  Cyrille Alexandre,et al.  The progeny of wingless-expressing cells deliver the signal at a distance in Drosophila embryos , 2000, Current Biology.

[66]  S. Roth,et al.  The role of brinker in mediating the graded response to Dpp in early Drosophila embryos. , 1999, Development.

[67]  J. Gurdon,et al.  A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[68]  S Pfeiffer,et al.  Signalling at a distance: transport of Wingless in the embryonic epidermis of Drosophila. , 1999, Seminars in cell & developmental biology.

[69]  M. Strigini,et al.  Formation of morphogen gradients in the Drosophila wing. , 1999, Seminars in cell & developmental biology.

[70]  T. Kornberg,et al.  Cytonemes Cellular Processes that Project to the Principal Signaling Center in Drosophila Imaginal Discs , 1999, Cell.

[71]  Pao-Tien Chuang,et al.  Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein , 1999, Nature.

[72]  Sangbin Park,et al.  Interpretation of a BMP Activity Gradient in Drosophila Embryos Depends on Synergistic Signaling by Two Type I Receptors, SAX and TKV , 1998, Cell.

[73]  D. Kullmann,et al.  Geometric and viscous components of the tortuosity of the extracellular space in the brain. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[74]  N. Perrimon,et al.  Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion , 1998, Nature.

[75]  Steven Dyson,et al.  The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors , 1998, Cell.

[76]  L Wolpert,et al.  Mechanisms for positional signalling by morphogen transport: a theoretical study. , 1998, Journal of theoretical biology.

[77]  B. Biehs,et al.  The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development. , 1996, Development.

[78]  M. Kerszberg Accurate reading of morphogen concentrations by nuclear receptors: a formal model of complex transduction pathways. , 1996, Journal of theoretical biology.

[79]  J. Wrana,et al.  The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor , 1996, Cell.

[80]  G. Struhl,et al.  Direct and Long-Range Action of a DPP Morphogen Gradient , 1996, Cell.

[81]  A. Ross,et al.  Cellular metabolism and activation of retinoids: roles of cellular retinoid‐binding proteins 2 , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[82]  M. Levine,et al.  Regulation of even‐skipped stripe 2 in the Drosophila embryo. , 1992, The EMBO journal.

[83]  K. Anderson,et al.  decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo , 1992, Cell.

[84]  C. Nüsslein-Volhard,et al.  The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner , 1988, Cell.

[85]  D. Koshland,et al.  An amplified sensitivity arising from covalent modification in biological systems. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[86]  H. Meinhardt,et al.  A theory of biological pattern formation , 1972, Kybernetik.

[87]  L. Wolpert Positional information and the spatial pattern of cellular differentiation. , 1969, Journal of theoretical biology.

[88]  A. M. Turing,et al.  The chemical basis of morphogenesis , 1952, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[89]  E. Schrödinger,et al.  What is life? : the physical aspect of the living cell , 1946 .

[90]  L. Hood,et al.  Reverse Engineering of Biological Complexity , 2007 .

[91]  D. Lauffenburger,et al.  Computational modeling of the EGF-receptor system: a paradigm for systems biology. , 2003, Trends in cell biology.

[92]  M. Gonzalez-Gaitan,et al.  Gradient formation of the TGF-beta homolog Dpp. , 2000, Cell.

[93]  F Pagès,et al.  Morphogen gradients. A question of time or concentration? , 2000, Trends in genetics : TIG.

[94]  F J Ayala,et al.  Adaptation and novelty: teleological explanations in evolutionary biology. , 1999, History and philosophy of the life sciences.