miRNA‐137‐5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin‐specific peptidase 30

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder causing progressive dementia. Research suggests that microRNAs (miRNAs) could serve as biomarkers and therapeutic targets for AD. Reduced levels of miR‐137 have been observed in the brains of AD patients, but its specific role and downstream mechanisms remain unclear. This study sought to examine the therapeutic potential of miR‐137‐5p agomir in alleviating cognitive dysfunction induced in AD models and explore its potential mechanisms.

[1]  Sajad Najafi,et al.  The role of microRNAs in the pathophysiology of human central nervous system: A focus on neurodegenerative diseases , 2023, Ageing Research Reviews.

[2]  Raquel Pereira,et al.  Electrochemical miRNA-34a-based biosensor for the diagnosis of Alzheimer's disease. , 2023, Bioelectrochemistry.

[3]  Renjie Li,et al.  Multimodal learning of clinically accessible tests to aid diagnosis of neurodegenerative disorders: a scoping review , 2023, Health Information Science and Systems.

[4]  Yu Feng,et al.  Bioinformatics analysis and prediction of Alzheimer’s disease and alcohol dependence based on Ferroptosis-related genes , 2023, Frontiers in aging neuroscience.

[5]  Jing Liu,et al.  miR‑137 is a diagnostic tumor‑suppressive miRNA that targets SPHK2 to promote M1‑type tumor‑associated macrophage polarization , 2023, Experimental and therapeutic medicine.

[6]  W. Nahas,et al.  Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer , 2023, International journal of molecular sciences.

[7]  B. de Strooper,et al.  microRNA-132 regulates gene expression programs involved in microglial homeostasis , 2023, iScience.

[8]  Erik J Behringer,et al.  Cerebrovascular miRNAs Track Early Development of Alzheimer's Disease and Target Molecular Markers of Angiogenesis and Blood Flow Regulation. , 2023, Journal of Alzheimer's disease : JAD.

[9]  A. Whitworth,et al.  FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo , 2023, bioRxiv.

[10]  P. Peplow,et al.  MicroRNAs in mouse and rat models of experimental epilepsy and potential therapeutic targets , 2023, Neural regeneration research.

[11]  A. Wawer,et al.  miR-9a-5p expression is decreased in the hippocampus of rats resistant to lamotrigine: A behavioural, molecular and bioinformatics assessment , 2023, Neuropharmacology.

[12]  A. Tamayol,et al.  Alzheimer’s Disease: Treatment Strategies and Their Limitations , 2022, International journal of molecular sciences.

[13]  Z. Sekawi,et al.  The evaluation expression of non-coding RNAs in response to HSV-G47∆ oncolytic virus infection in glioblastoma multiforme cancer stem cells , 2022, Journal of NeuroVirology.

[14]  Jing Chen,et al.  MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus , 2022, Journal of neuroinflammation.

[15]  Lan Wang,et al.  Role of miR‐21‐5p/FilGAP axis in estradiol alleviating the progression of monocrotaline‐induced pulmonary hypertension , 2022, Animal models and experimental medicine.

[16]  Yuanjie Xiao,et al.  Extracellular vesicles derived from astrocyte-treated with haFGF14-154 attenuate Alzheimer phenotype in AD mice , 2022, Theranostics.

[17]  O. Hansson,et al.  Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials , 2022, The Lancet Neurology.

[18]  Yue Zhao,et al.  Amyloid‐β protein and MicroRNA‐384 in NCAM‐Labeled exosomes from peripheral blood are potential diagnostic markers for Alzheimer's disease , 2022, CNS neuroscience & therapeutics.

[19]  Dzmitry G. Shcharbin,et al.  Circulating microRNAs in Medicine , 2022, International journal of molecular sciences.

[20]  Zhiyang Xie,et al.  USP30: Structure, Emerging Physiological Role, and Target Inhibition , 2022, Frontiers in Pharmacology.

[21]  Meghana Tare,et al.  Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective , 2022, Animal models and experimental medicine.

[22]  Lingpeng Zhu,et al.  Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis , 2022, Frontiers in Aging Neuroscience.

[23]  P. Reddy,et al.  Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria , 2021, Ageing Research Reviews.

[24]  Li-ning Su,et al.  Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease , 2021, Ageing Research Reviews.

[25]  Li Zhou,et al.  Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease , 2021, Animal models and experimental medicine.

[26]  Hongke Luo,et al.  Pharmacological inhibition of USP30 activates tissue‐specific mitophagy , 2021, Acta physiologica.

[27]  Yue Zhao,et al.  ABCA1-Labeled Exosomes in Serum Contain Higher MicroRNA-193b Levels in Alzheimer's Disease , 2021, BioMed research international.

[28]  Yuhang Yang,et al.  MicroRNA‐340‐5p increases telomere length by targeting telomere protein POT1 to improve Alzheimer's disease in mice , 2021, Cell biology international.

[29]  A. Nunomura,et al.  RNA and Oxidative Stress in Alzheimer's Disease: Focus on microRNAs , 2020, Oxidative medicine and cellular longevity.

[30]  R. Vandenbroucke,et al.  Extracellular Vesicles in Alzheimer’s and Parkinson’s Disease: Small Entities with Large Consequences , 2020, Cells.

[31]  D. Galimberti,et al.  MiRNA Profiling in Plasma Neural-Derived Small Extracellular Vesicles from Patients with Alzheimer’s Disease , 2020, Cells.

[32]  M. Joghataei,et al.  Large-scale analysis of MicroRNA expression in motor neuron-like cells derived from human umbilical cord blood mesenchymal stem cells , 2020, Scientific Reports.

[33]  J. Harper,et al.  Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling , 2020, Molecular cell.

[34]  Shaomin Li,et al.  Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways , 2020, Neurobiology of Disease.

[35]  Q. Tu,et al.  Estrogen protects neuroblastoma cell from amyloid-β 42 (Aβ42)-induced apoptosis via TXNIP/TRX axis and AMPK signaling , 2020, Neurochemistry International.

[36]  Yuting Tang,et al.  Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL pathways in burn wound healing , 2020, Cell Death & Disease.

[37]  Z. Fu,et al.  Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson’s disease , 2019, Brain Research.

[38]  K. Saliminejad,et al.  An overview of microRNAs: Biology, functions, therapeutics, and analysis methods , 2018, Journal of cellular physiology.

[39]  Yang Jiang,et al.  Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer’s Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells , 2018, Medical science monitor : international medical journal of experimental and clinical research.

[40]  Jiewen Zhang,et al.  miR-137 attenuates Aβ-induced neurotoxicity through inactivation of NF-κB pathway by targeting TNFAIP1 in Neuro2a cells. , 2017, Biochemical and biophysical research communications.

[41]  Shunjiang Xu,et al.  Deregulation of miRNA-181c potentially contributes to the pathogenesis of AD by targeting collapsin response mediator protein 2 in mice , 2016, Journal of the Neurological Sciences.

[42]  Liudi Yuan,et al.  High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model , 2015, PloS one.

[43]  Xingcai Zhang,et al.  Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration. , 2014, International journal of clinical and experimental pathology.

[44]  D. Kirkpatrick,et al.  The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy , 2014, Nature.

[45]  Wenxian Wu,et al.  MicroRNA-137 Is a Novel Hypoxia-responsive MicroRNA That Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX* , 2014, The Journal of Biological Chemistry.

[46]  Zheng Li,et al.  miR-137: A New Player in Schizophrenia , 2014, International journal of molecular sciences.

[47]  V. Calhoun,et al.  Potential Impact of miR-137 and Its Targets in Schizophrenia , 2013, Front. Genet..

[48]  Qinqin Wang,et al.  microRNA与肺癌 , 2010, Zhongguo fei ai za zhi = Chinese journal of lung cancer.

[49]  K. Feng,et al.  MiR-137-5p alleviates inflammation by upregulating IL-10R1 expression in rats with spinal cord injury. , 2019, European Review for Medical and Pharmacological Sciences.

[50]  R. H. Scofield,et al.  Western Blotting , 2015, Methods in Molecular Biology.

[51]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.