Rethinking how DNA methylation patterns are maintained

[1]  Peter A. Jones,et al.  Selective Anchoring of DNA Methyltransferases 3A and 3B to Nucleosomes Containing Methylated DNA , 2009, Molecular and Cellular Biology.

[2]  Robert S Illingworth,et al.  CpG islands – ‘A rough guide’ , 2009, FEBS letters.

[3]  David R. Liu,et al.  Conversion of 5-Methylcytosine to 5- Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1 , 2009 .

[4]  N. Heintz,et al.  The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain , 2009, Science.

[5]  H. Cedar,et al.  Linking DNA methylation and histone modification: patterns and paradigms , 2009, Nature Reviews Genetics.

[6]  A. Shilatifard,et al.  An operational definition of epigenetics. , 2009, Genes & development.

[7]  A. Probst,et al.  Epigenetic inheritance during the cell cycle , 2009, Nature Reviews Molecular Cell Biology.

[8]  E. Li,et al.  The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation , 2009, Nature Genetics.

[9]  S. Henikoff,et al.  Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks , 2008, Nature.

[10]  H. Cedar,et al.  De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes , 2008, Nature Structural &Molecular Biology.

[11]  D. Schübeler,et al.  DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity , 2008, The EMBO journal.

[12]  Juri Rappsilber,et al.  A model for transmission of the H3K27me3 epigenetic mark , 2008, Nature Cell Biology.

[13]  Yusuke Nakamura,et al.  Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism , 2008, Nature.

[14]  C. Arrowsmith,et al.  Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 , 2008, Nature.

[15]  S. Jacobsen,et al.  The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix , 2008, Nature.

[16]  Peter A. Jones,et al.  Moving AHEAD with an international human epigenome project , 2008, Nature.

[17]  E. Selker,et al.  Direct Interaction between DNA Methyltransferase DIM-2 and HP1 Is Required for DNA Methylation in Neurospora crassa , 2008, Molecular and Cellular Biology.

[18]  T. Bestor,et al.  The Colorful History of Active DNA Demethylation , 2008, Cell.

[19]  D. Gold,et al.  Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation , 2008, Nature Genetics.

[20]  K. Mitsuya,et al.  The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA , 2007, Nature.

[21]  Peter A. Jones,et al.  Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. , 2007, Cancer cell.

[22]  Y. Kohara,et al.  Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. , 2007, Human molecular genetics.

[23]  S. Jacobsen,et al.  UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells , 2007, Science.

[24]  T. Bestor,et al.  Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L , 2007, BMC Developmental Biology.

[25]  C. Allis,et al.  DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA , 2007, Nature.

[26]  H. Leonhardt,et al.  Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation , 2007, Nucleic acids research.

[27]  S. Pradhan,et al.  Functional cooperation between HP1 and DNMT1 mediates gene silencing. , 2007, Genes & development.

[28]  M. Fraga,et al.  The Polycomb group protein EZH2 directly controls DNA methylation , 2007, Nature.

[29]  E. Li,et al.  Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells , 2007, Nature Genetics.

[30]  E. Kremmer,et al.  DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells , 2007, The Journal of cell biology.

[31]  E. Lander,et al.  The Mammalian Epigenome , 2007, Cell.

[32]  Zohar Yakhini,et al.  Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer , 2007, Nature Genetics.

[33]  Peter A. Jones,et al.  Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival , 2006, Proceedings of the National Academy of Sciences.

[34]  Amos Tanay,et al.  Constitutive Nucleosome Depletion and Ordered Factor Assembly at the GRP78 Promoter Revealed by Single Molecule Footprinting , 2006, PLoS genetics.

[35]  Tomohiro Hayakawa,et al.  Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b , 2006, Genes to cells : devoted to molecular & cellular mechanisms.

[36]  Xiaoyu Zhang,et al.  Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2 , 2006, Science.

[37]  E. Li,et al.  Establishment and maintenance of DNA methylation patterns in mammals. , 2006, Current topics in microbiology and immunology.

[38]  Peter A. Jones,et al.  Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level , 2005, Nucleic acids research.

[39]  T. Owen-Hughes,et al.  De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases. , 2005, Biochemistry.

[40]  U. Bunz.  How Are Alkynes Scrambled? , 2005, Science.

[41]  Albert Jeltsch,et al.  The Dnmt1 DNA-(cytosine-C5)-methyltransferase Methylates DNA Processively with High Preference for Hemimethylated Target Sites* , 2004, Journal of Biological Chemistry.

[42]  G. Hager,et al.  Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro. , 2004, Biochemical and biophysical research communications.

[43]  A. Riggs,et al.  Methylation and epigenetic fidelity , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[44]  R. Scott Hansen,et al.  Hairpin-bisulfite PCR: Assessing epigenetic methylation patterns on complementary strands of individual DNA molecules , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  E. Li,et al.  Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b , 2003, Molecular and Cellular Biology.

[46]  T. Kouzarides,et al.  The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. , 2003, Nucleic acids research.

[47]  M. Groudine,et al.  Controlling the double helix , 2003, Nature.

[48]  H. Kato,et al.  G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. , 2002, Genes & development.

[49]  Bert Vogelstein,et al.  DNMT1 and DNMT3b cooperate to silence genes in human cancer cells , 2002, Nature.

[50]  Gangning Liang,et al.  Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements , 2002, Molecular and Cellular Biology.

[51]  T. Bestor,et al.  Dnmt3L and the Establishment of Maternal Genomic Imprints , 2001, Science.

[52]  K. Muegge,et al.  Lsh, a member of the SNF2 family, is required for genome-wide methylation. , 2001, Genes & development.

[53]  Matthew Tudor,et al.  Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation , 2001, Nature Genetics.

[54]  Peter L. Jones,et al.  DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters , 2000, Nature Genetics.

[55]  K. Robertson,et al.  Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. , 2000, Nucleic acids research.

[56]  J. Herman,et al.  CpG methylation is maintained in human cancer cells lacking DNMT1 , 2000, Nature.

[57]  C. Wijmenga,et al.  The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[58]  N. Tommerup,et al.  Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene , 1999, Nature.

[59]  D. Haber,et al.  DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.

[60]  R. Roberts,et al.  I. EXPRESSION, PURIFICATION, AND COMPARISON OF DE NOVO AND MAINTENANCE METHYLATION* , 1999 .

[61]  C. Walsh,et al.  Cytosine methylation and mammalian development. , 1999, Genes & development.

[62]  E. Li,et al.  Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. , 1998, Nucleic acids research.

[63]  P. Jones,et al.  The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines. , 1998, Cancer research.

[64]  H. Ng,et al.  Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. , 1997, Science.

[65]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[66]  A. Riggs,et al.  Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[67]  M. Turker,et al.  A partial methylation profile for a CpG site is stably maintained in mammalian tissues and cultured cell lines. , 1989, The Journal of biological chemistry.

[68]  V. Ingram,et al.  Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. , 1988, Journal of molecular biology.

[69]  Hamilton O. Smith,et al.  Methylases of the Type II Restriction-Modification Systems , 1984 .

[70]  A. Riggs,et al.  DNA methylation, biochemistry, and biological significance , 1984 .

[71]  V. Ingram,et al.  Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[72]  A. Bird,et al.  Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis. , 1978, Journal of molecular biology.

[73]  A. Bird,et al.  Use of restriction enzymes to study eukaryotic DNA methylation: II. The symmetry of methylated sites supports semi-conservative copying of the methylation pattern. , 1978, Journal of molecular biology.

[74]  R Holliday,et al.  DNA modification mechanisms and gene activity during development , 1975, Science.

[75]  Arthur D. Riggs,et al.  X inactivation, differentiation, and DNA methylation. , 1975, Cytogenetics and cell genetics.

[76]  F. Crick,et al.  Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid , 1974, Nature.