Response to Vaccination with a Commercial Inactivated Rabies Vaccine in a Captive Colony of Brazilian Free-Tailed Bats (Tadarida brasiliensis)

Abstract A captive colony of Brazilian free-tailed bats (Tadarida brasiliensis) was vaccinated with a commercial monovalent inactivated rabies virus (RABV) vaccine (RABVAC 1). Baseline rabies virus neutralizing antibodies (VNA) and the response to vaccination were measured in 50 bats. Rabies VNA was detected in the plasma of 64% (27/42) of bats that had been vaccinated 1 yr prior, but only 19% (8/42) had levels considered adequate. Rabies VNA was detected in the plasma of 63% (5/8) of bats with no record of previous vaccination, suggesting natural RABV exposure before captivity. All bats demonstrated a VNA response by 10 days postvaccination, and baseline titer significantly predicted humoral response to vaccination. No adverse reactions to vaccination or clinical signs of RABV infection were observed in the bats during a 6-mo observation period. Annual vaccination may maintain immunity against RABV infection in captive colonies of bats.

[1]  G. McCracken,et al.  EXPERIMENTAL RABIES VIRUS INFECTION OF BIG BROWN BATS (EPTESICUS FUSCUS) , 2008, Journal of wildlife diseases.

[2]  M. Meltzer,et al.  Human rabies prevention--United States, 2008: recommendations of the Advisory Committee on Immunization Practices. , 2008, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[3]  B. Blitvich,et al.  Experimental and natural infection of North American bats with West Nile virus. , 2005, The American journal of tropical medicine and hygiene.

[4]  J. Blanton,et al.  Efficacy of rabies biologics against new lyssaviruses from Eurasia. , 2005, Virus research.

[5]  C. Rupprecht,et al.  RABIES IN A CAPTIVE COLONY OF BIG BROWN BATS (EPTESICUS FUSCUS) , 2004, Journal of wildlife diseases.

[6]  D. Heard,et al.  VACCINATION OF EGYPTIAN FRUIT BATS (ROUSETTUS AEGYPTIACUS) WITH MONOVALENT INACTIVATEDRABIES VACCINE , 2004, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.

[7]  B. Brochier,et al.  VACCINATION OF VAMPIRE BATS USING RECOMBINANT VACCINIA-RABIES VIRUS , 2002, Journal of wildlife diseases.

[8]  H. Field,et al.  Australian bat lyssavirus infection in a captive juvenile black flying fox. , 1999, Emerging infectious diseases.

[9]  Brian W Keeley,et al.  Bats in American Bridges , 1999 .

[10]  W. Schaftenaar Clinically silent rabies infection in (zoo) bats. , 1998, The Veterinary record.

[11]  N. Tordo,et al.  Experimental rabies infection and oral vaccination in vampire bats (Desmodus rotundus). , 1998, Vaccine.

[12]  K. Sorensen,et al.  Clinically silent rabies infection in (zoo) bats , 1998, The Veterinary Record.

[13]  A. Allworth,et al.  A human case of encephalitis due to a lyssavirus recently identified in fruit bats , 1996 .

[14]  R. Steece,et al.  PREVALENCE OF RABIES SPECIFIC ANTIBODIES IN THE MEXICAN FREE-TAILED BAT (TADARIDA BRASILIENSIS MEXICANA) AT LAVA CAVE, NEW MEXICO , 1989, Journal of wildlife diseases.

[15]  G. Baer,et al.  Dual role of the immune response in street rabiesvirus infection of mice , 1982, Infection and immunity.

[16]  B. Prabhakar,et al.  Acute rabies death mediated by antibody , 1981, Nature.

[17]  J. Smith Mouse model for abortive rabies infection of the central nervous system , 1981, Infection and immunity.

[18]  D. Hawkins,et al.  Rabies in New Mexico cavern bats. , 1968, Public health reports.