Clostridium scindens metabolites trigger prostate cancer progression through androgen receptor signaling.

[1]  Md. Rezaul Islam,et al.  Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies. , 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[2]  Dayeong Kim,et al.  Use of antimicrobial agents in actively dying inpatients after suspension of life-sustaining treatments: Suggestion for antimicrobial stewardship. , 2022, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[3]  S. Dunwoodie,et al.  An image analysis protocol using CellProfiler for automated quantification of post-ischemic cardiac parameters , 2022, STAR Protocols.

[4]  Yin Lu,et al.  Gut Microbiota-Mediated Modulation of Cancer Progression and Therapy Efficacy , 2021, Frontiers in Cell and Developmental Biology.

[5]  P. Kashyap,et al.  The promise of the gut microbiome as part of individualized treatment strategies , 2021, Nature Reviews Gastroenterology & Hepatology.

[6]  C. Chiu,et al.  Campylobacter jejuni Cytolethal Distending Toxin C Exploits Lipid Rafts to Mitigate Helicobacter pylori-Induced Pathogenesis , 2021, Frontiers in Cell and Developmental Biology.

[7]  S. Reynolds,et al.  The human microbiome and its link in prostate cancer risk and pathogenesis , 2020, Infectious agents and cancer.

[8]  R. Auchus,et al.  The role of adrenal derived androgens in castration resistant prostate cancer , 2020, The Journal of Steroid Biochemistry and Molecular Biology.

[9]  Ting-Yu Yen,et al.  Recommendations and guidelines for the treatment of Clostridioides difficile infection in Taiwan. , 2020, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[10]  Ruiyuan Xu,et al.  The role of JNK in prostate cancer progression and therapeutic strategies. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[11]  Matthew E. Hudson,et al.  Bacterial steroid-17,20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1,4-androstanediene-3,11,17-trione, a metabolite that causes proliferation of prostate cancer cells , 2019, The Journal of Steroid Biochemistry and Molecular Biology.

[12]  E. Giovannucci,et al.  The Epidemiology of Prostate Cancer. , 2018, Cold Spring Harbor perspectives in medicine.

[13]  J. Snoep,et al.  11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): Implications for castration resistant prostate cancer , 2018, The Journal of Steroid Biochemistry and Molecular Biology.

[14]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[15]  J. Rubin,et al.  Antimicrobial Resistance in Clostridium and Brachyspira spp. and Other Anaerobes , 2018, Microbiology spectrum.

[16]  S. Devendran,et al.  The desA and desB genes from Clostridium scindens ATCC 35704 encode steroid-17,20-desmolase[S] , 2018, Journal of Lipid Research.

[17]  A. Gursoy,et al.  Androgen receptor binding sites are highly mutated in prostate cancer , 2017, bioRxiv.

[18]  H. Klocker,et al.  The Glucocorticoid Receptor Is a Key Player for Prostate Cancer Cell Survival and a Target for Improved Antiandrogen Therapy , 2017, Clinical Cancer Research.

[19]  H. He,et al.  Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer , 2017, Oncogene.

[20]  N. Sharifi,et al.  Androgen Signaling in Prostate Cancer. , 2017, Cold Spring Harbor perspectives in medicine.

[21]  E. Hwang,et al.  Antibiotic Prophylaxis in Radical Prostatectomy: Comparison of 2-Day and More than 2-Day Prophylaxis , 2017, Journal of Korean medical science.

[22]  A. Serafin,et al.  Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone , 2017, The Journal of Steroid Biochemistry and Molecular Biology.

[23]  K. Storbeck,et al.  11-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored , 2016, PloS one.

[24]  T. Giordano,et al.  Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency. , 2016, European journal of endocrinology.

[25]  C. Gomez-Sanchez,et al.  Development of a novel cell based androgen screening model , 2016, The Journal of Steroid Biochemistry and Molecular Biology.

[26]  P. Hylemon,et al.  Consequences of bile salt biotransformations by intestinal bacteria , 2016, Gut microbes.

[27]  Rustem F. Ismagilov,et al.  Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis , 2015, Cell.

[28]  S. Mittnacht,et al.  Workflow for High-content, Individual Cell Quantification of Fluorescent Markers from Universal Microscope Data, Supported by Open Source Software , 2014, Journal of visualized experiments : JoVE.

[29]  Chris Sander,et al.  Precision microbiome restoration of bile acid-mediated resistance to Clostridium difficile , 2014, Nature.

[30]  S. Balk,et al.  Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis , 2014, Oncogene.

[31]  J. Luo,et al.  Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospects , 2014, Oncogene.

[32]  D. Zheng,et al.  Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade , 2013, Cell.

[33]  G. Buck,et al.  Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens , 2013, Journal of Lipid Research.

[34]  T. Kawasaki,et al.  Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer , 2013, Scientific Reports.

[35]  R. Auchus,et al.  Steroid biosynthesis and prostate cancer , 2012, Steroids.

[36]  L. Saba,et al.  Differential expression of determinants of glucocorticoid sensitivity in androgen-dependent and androgen-independent human prostate cancer cell lines , 2009, The Journal of Steroid Biochemistry and Molecular Biology.

[37]  P. Nelson,et al.  Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. , 2008, Cancer research.

[38]  G. Bubley,et al.  Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1 , 2006, Proceedings of the National Academy of Sciences.

[39]  Dae-Joong Kang,et al.  Bile salt biotransformations by human intestinal bacteria Published, JLR Papers in Press, November 18, 2005. , 2006, Journal of Lipid Research.

[40]  H. Scher,et al.  Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  Donna M. Peehl,et al.  Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor , 2000, Nature Medicine.

[42]  E. Wilson,et al.  Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones. , 1992, The Journal of biological chemistry.

[43]  P. Hylemon,et al.  Purification and characterization of a novel form of 20 alpha-hydroxysteroid dehydrogenase from Clostridium scindens , 1989, Journal of bacteriology.

[44]  V. Bokkenheuser,et al.  Cofactor requirements of steroid-17-20-desmolase and 20 alpha-hydroxysteroid dehydrogenase activities in cell extracts of Clostridium scindens. , 1987, Journal of steroid biochemistry.

[45]  J. Geller,et al.  Effects of castration compared with total androgen blockade on tissue dihydrotestosterone (DHT) concentration in benign prostatic hyperplasia (BPH) , 1987, Urological Research.

[46]  E. Mosbach,et al.  Mode of action of steroid desmolase and reductases synthesized by Clostridium "scindens" (formerly Clostridium strain 19). , 1984, Journal of lipid research.

[47]  C. Huttenhower,et al.  The Role of Gut Microbiome in the Pathogenesis of Prostate Cancer: A Prospective, Pilot Study. , 2018, Urology.

[48]  S. Srinivas,et al.  Androgen–glucocorticoid interactions in the era of novel prostate cancer therapy , 2016, Nature Reviews Urology.

[49]  A. Horwich,et al.  Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.