Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
暂无分享,去创建一个
T. Golub | P. Clemons | S. Schreiber | B. Ebert | A. Shamji | V. Dancík | D. Scadden | A. Vetere | K. Hartwell | N. Tolliday | N. Raje | T. Hideshima | L. Carmody | M. Moore | A. Stern | Rakesh Karmacharya | L. Santo | R. Yusuf | S. Mukherjee | D. Cirstea | Joshiawa Paulk | Alykhan F. Shamji | Kimberly A. Hartwell | S. Chattopadhyay | S. Vallet | D. Sykes | Mahmud M. Hussain | R. Subramanian | Jonathan Iaconelli | Shambhavi Singh | P. Miller | Cherrie Huang | Alison L. Stewart | M. M. Majireck | Ryan Quiroz
[1] A. McKenna,et al. Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. , 2014, Cancer cell.
[2] Brian M. Owens. Kinesin inhibitor marches toward first-in-class pivotal trial , 2013, Nature Medicine.
[3] A. Heijink,et al. Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination , 2013, Oncogene.
[4] H. B. El-Nassan,et al. Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. , 2013, European journal of medicinal chemistry.
[5] O. Rath,et al. Structural insights into a unique inhibitor binding pocket in kinesin spindle protein. , 2013, Journal of the American Chemical Society.
[6] P. Albers,et al. Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer , 2013, Investigational New Drugs.
[7] S. Lonial,et al. ARRY-520 Shows Durable Responses in Patients with Relapsed/Refractory Multiple Myeloma in a Phase 1 Dose-Escalation Study , 2011 .
[8] D. Swinney,et al. How were new medicines discovered? , 2011, Nature Reviews Drug Discovery.
[9] Suzanne F. Jones,et al. A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors , 2011, Investigational New Drugs.
[10] J. Richard,et al. Allosteric Drug Discrimination Is Coupled to Mechanochemical Changes in the Kinesin-5 Motor Core* , 2010, The Journal of Biological Chemistry.
[11] K. Anderson,et al. Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anti-cancer drug activity , 2010, Nature Medicine.
[12] W. Kuo,et al. Activity of the Kinesin Spindle Protein Inhibitor Ispinesib (SB-715992) in Models of Breast Cancer , 2010, Clinical Cancer Research.
[13] B. Tunquist,et al. ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. , 2009, Anticancer Research.
[14] Hirdesh Uppal,et al. In vitro to in vivo concordance of a high throughput assay of bone marrow toxicity across a diverse set of drug candidates. , 2009, Toxicology letters.
[15] B. Teicher,et al. Bone marrow CFU-GM and human tumor xenograft efficacy of three antitumor nucleoside analogs. , 2009, International journal of oncology.
[16] B. Teicher,et al. Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents , 2009, Cancer Chemotherapy and Pharmacology.
[17] A. Rath,et al. Detergent binding explains anomalous SDS-PAGE migration of membrane proteins , 2009, Proceedings of the National Academy of Sciences.
[18] A. Merdes,et al. Spindle assembly defects leading to the formation of a monopolar mitotic apparatus , 2009, Biology of the cell.
[19] Laurence Lodé,et al. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myélome. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[20] S. Tsao,et al. Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A. , 2008, Molecular biology of the cell.
[21] W. Dalton,et al. The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance , 2008, Clinical Cancer Research.
[22] Stuart L Schreiber,et al. Towards the optimal screening collection: a synthesis strategy. , 2008, Angewandte Chemie.
[23] Latesh Lad,et al. Mechanism of inhibition of human KSP by ispinesib. , 2008, Biochemistry.
[24] Neysa Nevins,et al. ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. , 2007, Nature chemical biology.
[25] Makoto Kinoshita,et al. [Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen]. , 2007, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
[26] R. Wäsch,et al. Characterization of in vitro growth of multiple myeloma cells. , 2007, Experimental hematology.
[27] Kenneth C. Anderson,et al. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets , 2007, Nature Reviews Cancer.
[28] E. Salmon,et al. The spindle-assembly checkpoint in space and time , 2007, Nature Reviews Molecular Cell Biology.
[29] W. Dalton,et al. Synopsis of a Roundtable on Validating Novel Therapeutics for Multiple Myeloma , 2006, Clinical Cancer Research.
[30] Paul A Clemons,et al. The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease , 2006, Science.
[31] Hongmao Sun,et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[32] S. Rafii,et al. Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro. , 2005, Stem cells and development.
[33] R. Copeland,et al. Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition. , 2004, Biochemistry.
[34] Angus G. Dalgleish,et al. The evolution of thalidomide and its IMiD derivatives as anticancer agents , 2004, Nature Reviews Cancer.
[35] D Parent-Massin,et al. Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.
[36] B. Dörken,et al. In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway. , 2002, Blood.
[37] P. Elliott,et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. , 2001, Cancer research.
[38] G Muller,et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. , 2000, Blood.
[39] K. Orita,et al. Human bone marrow stroma‐dependent cell line MOLP‐5 derived from a patient in leukaemic phase of multiple myeloma , 2000, British journal of haematology.
[40] S. Haggarty,et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. , 1999, Science.
[41] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[42] M. Ghielmini,et al. Predicting hematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests. , 1998, Annals of oncology : official journal of the European Society for Medical Oncology.
[43] L. Dick,et al. Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. , 1998, Bioorganic & medicinal chemistry letters.
[44] T. Facon,et al. MULTIPLE MYELOMA: ALMOST ALL PATIENTS ARE CYTOGENETICALLY ABNORMAL , 1996, British journal of haematology.
[45] H. Lane,et al. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo , 1995, Cell.
[46] R F Standaert,et al. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin , 1995, Science.
[47] M. Dimopoulos,et al. Primary therapy of multiple myeloma with paclitaxel (taxol). , 1994, Annals of oncology : official journal of the European Society for Medical Oncology.
[48] Salmon Se,et al. Adriamycin (NSC-123127) in the treatment of alkylator-resistant multiple myeloma: a pilot study. , 1975 .
[49] Jacques Ferlay,et al. GLOBOCAN 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012 , 2013 .
[50] M. Gordon. Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma , 2006 .
[51] R. Parchment,et al. Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro , 1997, Cancer Chemotherapy and Pharmacology.
[52] D. Alberts,et al. Adriamycin (NSC-123127) in the treatment of alkylator-resistant multiple myeloma: a pilot study. , 1975, Cancer chemotherapy reports.
[53] A. W. Schüttelkopf,et al. Biological Crystallography the Structure of the Ternary Eg5–adp–ispinesib Complex , 2022 .